A7YG54 · A7YG54_MUSNI
- ProteinCytochrome b
- Genecytb
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids379 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 heme groups non-covalently.
Note: Binds 2 heme groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 83 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 97 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 182 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 196 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 201 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | respiratory electron transport chain |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Musteloidea > Mustelidae > Mustelinae > Mustela
Accessions
- Primary accessionA7YG54
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 30-52 | Helical | ||||
Sequence: WWNFGSLLGICLIIQILTGLFLA | ||||||
Transmembrane | 87-107 | Helical | ||||
Sequence: ASMFFICLFLHVGRGLYYGSY | ||||||
Transmembrane | 113-133 | Helical | ||||
Sequence: WNIGIILLFAVMATAFMGYVL | ||||||
Transmembrane | 140-158 | Helical | ||||
Sequence: FWGATVITNLLSAIPYIGT | ||||||
Transmembrane | 178-200 | Helical | ||||
Sequence: FFAFHFILPFIISALAAVHLLFL | ||||||
Transmembrane | 229-246 | Helical | ||||
Sequence: ILGALFLILTLMLLVLFS | ||||||
Transmembrane | 288-307 | Helical | ||||
Sequence: LGGVLALVFSILVLAIIPLL | ||||||
Transmembrane | 319-338 | Helical | ||||
Sequence: PLSQCLFWLLVADLLTLTWI | ||||||
Transmembrane | 350-372 | Helical | ||||
Sequence: IGQLASILYFMILLVLMPIISII |
Keywords
- Cellular component
Interaction
Subunit
The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-209 | Cytochrome b/b6 N-terminal region profile | ||||
Sequence: MTNIRKTHPLTKIINNSFIDLPAPSNISAWWNFGSLLGICLIIQILTGLFLAMHYTSDTATAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFLHVGRGLYYGSYMFSETWNIGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIISALAAVHLLFLHETGSNNPS | ||||||
Domain | 210-379 | Cytochrome b/b6 C-terminal region profile | ||||
Sequence: GIPSDSDKIPFHPYYTIKDILGALFLILTLMLLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILVLAIIPLLHTSKQRSMMFRPLSQCLFWLLVADLLTLTWIGGQPVEHPFVTIGQLASILYFMILLVLMPIISIIENNMLKW |
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length379
- Mass (Da)42,677
- Last updated2007-10-23 v1
- Checksum62D496197BBA8711
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EF689080 EMBL· GenBank· DDBJ | ABU93741.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF689081 EMBL· GenBank· DDBJ | ABU93742.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF987744 EMBL· GenBank· DDBJ | ABV57065.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ153573 EMBL· GenBank· DDBJ | ACT53025.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM106319 EMBL· GenBank· DDBJ | ADG22650.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN819537 EMBL· GenBank· DDBJ | AFH54005.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN819538 EMBL· GenBank· DDBJ | AFH54006.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN819539 EMBL· GenBank· DDBJ | AFH54007.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN819540 EMBL· GenBank· DDBJ | AFH54008.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN819549 EMBL· GenBank· DDBJ | AFH54017.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN819550 EMBL· GenBank· DDBJ | AFH54018.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN819551 EMBL· GenBank· DDBJ | AFH54019.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN819552 EMBL· GenBank· DDBJ | AFH54020.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT901457 EMBL· GenBank· DDBJ | ALT55499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT693382 EMBL· GenBank· DDBJ | AMM05292.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF459691 EMBL· GenBank· DDBJ | AXJ93325.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB564122 EMBL· GenBank· DDBJ | BAK19348.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB564123 EMBL· GenBank· DDBJ | BAK19349.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB564125 EMBL· GenBank· DDBJ | BAK19351.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB564127 EMBL· GenBank· DDBJ | BAK19353.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB564128 EMBL· GenBank· DDBJ | BAK19354.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB564129 EMBL· GenBank· DDBJ | BAK19355.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB564130 EMBL· GenBank· DDBJ | BAK19356.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324904 EMBL· GenBank· DDBJ | BBF88154.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324905 EMBL· GenBank· DDBJ | BBF88155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324906 EMBL· GenBank· DDBJ | BBF88156.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324907 EMBL· GenBank· DDBJ | BBF88157.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324908 EMBL· GenBank· DDBJ | BBF88158.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324909 EMBL· GenBank· DDBJ | BBF88159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324911 EMBL· GenBank· DDBJ | BBF88161.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324913 EMBL· GenBank· DDBJ | BBF88163.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324915 EMBL· GenBank· DDBJ | BBF88165.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324916 EMBL· GenBank· DDBJ | BBF88166.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324917 EMBL· GenBank· DDBJ | BBF88167.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324918 EMBL· GenBank· DDBJ | BBF88168.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324919 EMBL· GenBank· DDBJ | BBF88169.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324920 EMBL· GenBank· DDBJ | BBF88170.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324921 EMBL· GenBank· DDBJ | BBF88171.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324923 EMBL· GenBank· DDBJ | BBF88173.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324924 EMBL· GenBank· DDBJ | BBF88174.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324925 EMBL· GenBank· DDBJ | BBF88175.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324926 EMBL· GenBank· DDBJ | BBF88176.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324927 EMBL· GenBank· DDBJ | BBF88177.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324928 EMBL· GenBank· DDBJ | BBF88178.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324929 EMBL· GenBank· DDBJ | BBF88179.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324930 EMBL· GenBank· DDBJ | BBF88180.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324933 EMBL· GenBank· DDBJ | BBF88183.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324934 EMBL· GenBank· DDBJ | BBF88184.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324936 EMBL· GenBank· DDBJ | BBF88186.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324949 EMBL· GenBank· DDBJ | BBF88199.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC324952 EMBL· GenBank· DDBJ | BBF88202.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258837 EMBL· GenBank· DDBJ | CAJ88860.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258838 EMBL· GenBank· DDBJ | CAJ88861.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258839 EMBL· GenBank· DDBJ | CAJ88862.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258843 EMBL· GenBank· DDBJ | CAJ88866.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258844 EMBL· GenBank· DDBJ | CAJ88867.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258845 EMBL· GenBank· DDBJ | CAJ88868.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258847 EMBL· GenBank· DDBJ | CAJ88870.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258848 EMBL· GenBank· DDBJ | CAJ88871.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258849 EMBL· GenBank· DDBJ | CAJ88872.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258854 EMBL· GenBank· DDBJ | CAJ88877.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258861 EMBL· GenBank· DDBJ | CAJ88884.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258862 EMBL· GenBank· DDBJ | CAJ88885.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258864 EMBL· GenBank· DDBJ | CAJ88887.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258865 EMBL· GenBank· DDBJ | CAJ88888.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258869 EMBL· GenBank· DDBJ | CAJ88892.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258871 EMBL· GenBank· DDBJ | CAJ88894.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258872 EMBL· GenBank· DDBJ | CAJ88895.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258873 EMBL· GenBank· DDBJ | CAJ88896.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258874 EMBL· GenBank· DDBJ | CAJ88897.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258875 EMBL· GenBank· DDBJ | CAJ88898.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258876 EMBL· GenBank· DDBJ | CAJ88899.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258877 EMBL· GenBank· DDBJ | CAJ88900.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258878 EMBL· GenBank· DDBJ | CAJ88901.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258879 EMBL· GenBank· DDBJ | CAJ88902.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258880 EMBL· GenBank· DDBJ | CAJ88903.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258882 EMBL· GenBank· DDBJ | CAJ88905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258887 EMBL· GenBank· DDBJ | CAJ88910.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258889 EMBL· GenBank· DDBJ | CAJ88912.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258890 EMBL· GenBank· DDBJ | CAJ88913.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM258891 EMBL· GenBank· DDBJ | CAJ88914.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM932884 EMBL· GenBank· DDBJ | CAP69673.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM932885 EMBL· GenBank· DDBJ | CAP69674.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW257229 EMBL· GenBank· DDBJ | QQW47906.1 EMBL· GenBank· DDBJ | Genomic DNA |