A7Y7W3 · NANOG_CHICK

  • Protein
    Homeobox protein NANOG
  • Gene
    NANOG
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Transcription factor required for the maintenance of pluripotency and self-renewal of embryonic stem cells.

Features

Showing features for dna binding.

130920406080100120140160180200220240260280300
TypeIDPosition(s)Description
DNA binding98-157Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functiontranscription cis-regulatory region binding
Biological Processpositive regulation of stem cell population maintenance
Biological Processregulation of transcription by RNA polymerase II
Biological Processstem cell population maintenance

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Homeobox protein NANOG
  • Alternative names
    • Homeobox transcription factor Nanog (cNanog)

Gene names

    • Name
      NANOG

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Red jungle fowl
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    A7Y7W3
  • Secondary accessions
    • R4GLF7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004336271-309Homeobox protein NANOG

Proteomic databases

Expression

Induction

Strongly down-regulated during embryonic stem cell differentiation, induced either by retinoic acid treatment, or by cell adhesion prevention leading to embryoid body formation.

Developmental stage

During embryonic development, expressed preferentially in epiblastic cells and germ cells. In pre-streak embryos, detected in the whole epiblast, but not in the forming hypoblast (stages XI through XIII) (at protein level). As the primitive streak starts to form, disappears from the primitive streak epiblast, but still expressed throughout the area pellucida epiblast (stage XIV -> 3+). At the end of gastrulation (stage 4+), quickly decreases in the epiblast and persists in a crescent anterior to the emerging head process (stages 4+ through 6). At stage 5, strongly expressed in some of the cells in the germinal crescent, probably corresponding primordial germ cells. At stage 7 (neurula stage), undetectable in differentiated cells (at protein level). As the neural plate forms (stages 6-8), expression in the epiblast is restricted to the anterior neural plate. At stage 33, still expressed in germ cells. At stages 42-43, expressed in gonads, as well as in brain, kidney and heart, but at much lower levels than in proliferating embryonic stem cells.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region24-104Disordered
Compositional bias40-80Polar residues
Compositional bias82-98Basic and acidic residues

Sequence similarities

Belongs to the Nanog homeobox family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    309
  • Mass (Da)
    34,310
  • Last updated
    2015-09-16 v2
  • Checksum
    4532E7BA928159A6
MSAHLAMPSYGSVRCGHYYWPSPGSMDSASAAEAPAADLSLTTEQKTPCHPDASPASSSSGTLIQYTPDSATSPTADHPSHRPTFQKVKDKGESGTRKAKSRTAFSQEQLQTLHQRFQSQKYLSPHQIRELAAALGLTYKQVKTWFQNQRMKFKRCQKESQWVDKGIYLPQNGFHQAAYLDMTPTFHQGFPVVTNRNLQAVTSAHQAYSSGQTYGNGQGLYPFMAVEDEGFFGKGGTSCNTQQAMGLLSQQMNFYHGYSTNVDYDSLQAEDTYSFQSTSDSITQFSSSPVRHQYQAPWHTLGTQNGYET

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias40-80Polar residues
Compositional bias82-98Basic and acidic residues
Sequence conflict194in Ref. 1; ABK27429

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ867025
EMBL· GenBank· DDBJ
ABK27429.1
EMBL· GenBank· DDBJ
mRNA
AADN03000707
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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