A7XSL3 · A7XSL3_HUMAN

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

138050100150200250300350
TypeIDPosition(s)Description
Binding site83Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site97Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site182Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site196Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site201a ubiquinone (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processrespiratory electron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      cytb
    • Synonyms
      CYTB

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Cayapa511
    • MB106
    • CHP265_Chachapoya
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A7XSL3

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-56Helical
Transmembrane77-98Helical
Transmembrane113-133Helical
Transmembrane140-158Helical
Transmembrane178-200Helical
Transmembrane229-246Helical
Transmembrane288-308Helical
Transmembrane320-339Helical
Transmembrane345-372Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome b/b6 N-terminal region profile
Domain210-380Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    380
  • Mass (Da)
    42,710
  • Last updated
    2007-10-23 v1
  • Checksum
    BFC5033F55406642
MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYPETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU095529
EMBL· GenBank· DDBJ
ABU46780.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ245732
EMBL· GenBank· DDBJ
AEY70969.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702324
EMBL· GenBank· DDBJ
AFF68182.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ704789
EMBL· GenBank· DDBJ
AFG00228.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ627742
EMBL· GenBank· DDBJ
AHN65766.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ920750
EMBL· GenBank· DDBJ
AIC32661.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ923839
EMBL· GenBank· DDBJ
AIJ18847.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ923840
EMBL· GenBank· DDBJ
AIJ18860.1
EMBL· GenBank· DDBJ
Genomic DNA
KM102053
EMBL· GenBank· DDBJ
AIU63400.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645517
EMBL· GenBank· DDBJ
ASR12510.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645519
EMBL· GenBank· DDBJ
ASR12536.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645534
EMBL· GenBank· DDBJ
ASR12731.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645536
EMBL· GenBank· DDBJ
ASR12757.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645537
EMBL· GenBank· DDBJ
ASR12770.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645539
EMBL· GenBank· DDBJ
ASR12796.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645541
EMBL· GenBank· DDBJ
ASR12822.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645544
EMBL· GenBank· DDBJ
ASR12861.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645573
EMBL· GenBank· DDBJ
ASR13238.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645580
EMBL· GenBank· DDBJ
ASR13329.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645598
EMBL· GenBank· DDBJ
ASR13563.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645599
EMBL· GenBank· DDBJ
ASR13576.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645600
EMBL· GenBank· DDBJ
ASR13589.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645613
EMBL· GenBank· DDBJ
ASR13758.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645671
EMBL· GenBank· DDBJ
ASR14512.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645683
EMBL· GenBank· DDBJ
ASR14668.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645755
EMBL· GenBank· DDBJ
ASR15604.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645830
EMBL· GenBank· DDBJ
ASR16579.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645834
EMBL· GenBank· DDBJ
ASR16631.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645838
EMBL· GenBank· DDBJ
ASR16683.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645843
EMBL· GenBank· DDBJ
ASR16748.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645845
EMBL· GenBank· DDBJ
ASR16774.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645846
EMBL· GenBank· DDBJ
ASR16787.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645861
EMBL· GenBank· DDBJ
ASR16982.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645868
EMBL· GenBank· DDBJ
ASR17073.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645869
EMBL· GenBank· DDBJ
ASR17086.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645870
EMBL· GenBank· DDBJ
ASR17099.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645878
EMBL· GenBank· DDBJ
ASR17203.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645879
EMBL· GenBank· DDBJ
ASR17216.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645880
EMBL· GenBank· DDBJ
ASR17229.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645881
EMBL· GenBank· DDBJ
ASR17242.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645882
EMBL· GenBank· DDBJ
ASR17255.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645893
EMBL· GenBank· DDBJ
ASR17398.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645904
EMBL· GenBank· DDBJ
ASR17541.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645906
EMBL· GenBank· DDBJ
ASR17567.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645907
EMBL· GenBank· DDBJ
ASR17580.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645909
EMBL· GenBank· DDBJ
ASR17606.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645910
EMBL· GenBank· DDBJ
ASR17619.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645916
EMBL· GenBank· DDBJ
ASR17697.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645923
EMBL· GenBank· DDBJ
ASR17788.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645925
EMBL· GenBank· DDBJ
ASR17814.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645926
EMBL· GenBank· DDBJ
ASR17827.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680794
EMBL· GenBank· DDBJ
ASZ80423.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680795
EMBL· GenBank· DDBJ
ASZ80436.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680796
EMBL· GenBank· DDBJ
ASZ80449.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680797
EMBL· GenBank· DDBJ
ASZ80462.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680798
EMBL· GenBank· DDBJ
ASZ80475.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680799
EMBL· GenBank· DDBJ
ASZ80488.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680800
EMBL· GenBank· DDBJ
ASZ80501.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680801
EMBL· GenBank· DDBJ
ASZ80514.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680802
EMBL· GenBank· DDBJ
ASZ80527.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680805
EMBL· GenBank· DDBJ
ASZ80566.1
EMBL· GenBank· DDBJ
Genomic DNA
KY681011
EMBL· GenBank· DDBJ
ASZ83244.1
EMBL· GenBank· DDBJ
Genomic DNA
MF152738
EMBL· GenBank· DDBJ
ATP84919.1
EMBL· GenBank· DDBJ
Genomic DNA
MT419161
EMBL· GenBank· DDBJ
QMP93626.1
EMBL· GenBank· DDBJ
Genomic DNA
MN857296
EMBL· GenBank· DDBJ
QTK14415.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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