A7XSL3 · A7XSL3_HUMAN
- ProteinCytochrome b
- Genecytb
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids380 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 heme groups non-covalently.
Note: Binds 2 heme groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 83 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 97 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 182 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 196 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 201 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | respiratory electron transport chain |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA7XSL3
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 30-56 | Helical | ||||
Sequence: WWNFGSLLGACLILQITTGLFLAMHYS | ||||||
Transmembrane | 77-98 | Helical | ||||
Sequence: WIIRYLHANGASMFFICLFLHI | ||||||
Transmembrane | 113-133 | Helical | ||||
Sequence: WNIGIILLLATMATAFMGYVL | ||||||
Transmembrane | 140-158 | Helical | ||||
Sequence: FWGATVITNLLSAIPYIGT | ||||||
Transmembrane | 178-200 | Helical | ||||
Sequence: FFTFHFILPFIIAALAALHLLFL | ||||||
Transmembrane | 229-246 | Helical | ||||
Sequence: ALGLLLFLLSLMTLTLFS | ||||||
Transmembrane | 288-308 | Helical | ||||
Sequence: LGGVLALLLSILILAMIPILH | ||||||
Transmembrane | 320-339 | Helical | ||||
Sequence: LSQSLYWLLAADLLILTWIG | ||||||
Transmembrane | 345-372 | Helical | ||||
Sequence: YPFTIIGQVASVLYFTTILILMPTISLI |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Interaction
Subunit
The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-209 | Cytochrome b/b6 N-terminal region profile | ||||
Sequence: MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYPETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPL | ||||||
Domain | 210-380 | Cytochrome b/b6 C-terminal region profile | ||||
Sequence: GITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA |
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length380
- Mass (Da)42,710
- Last updated2007-10-23 v1
- ChecksumBFC5033F55406642
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU095529 EMBL· GenBank· DDBJ | ABU46780.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ245732 EMBL· GenBank· DDBJ | AEY70969.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702324 EMBL· GenBank· DDBJ | AFF68182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ704789 EMBL· GenBank· DDBJ | AFG00228.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ627742 EMBL· GenBank· DDBJ | AHN65766.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ920750 EMBL· GenBank· DDBJ | AIC32661.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ923839 EMBL· GenBank· DDBJ | AIJ18847.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ923840 EMBL· GenBank· DDBJ | AIJ18860.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM102053 EMBL· GenBank· DDBJ | AIU63400.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645517 EMBL· GenBank· DDBJ | ASR12510.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645519 EMBL· GenBank· DDBJ | ASR12536.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645534 EMBL· GenBank· DDBJ | ASR12731.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645536 EMBL· GenBank· DDBJ | ASR12757.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645537 EMBL· GenBank· DDBJ | ASR12770.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645539 EMBL· GenBank· DDBJ | ASR12796.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645541 EMBL· GenBank· DDBJ | ASR12822.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645544 EMBL· GenBank· DDBJ | ASR12861.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645573 EMBL· GenBank· DDBJ | ASR13238.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645580 EMBL· GenBank· DDBJ | ASR13329.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645598 EMBL· GenBank· DDBJ | ASR13563.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645599 EMBL· GenBank· DDBJ | ASR13576.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645600 EMBL· GenBank· DDBJ | ASR13589.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645613 EMBL· GenBank· DDBJ | ASR13758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645671 EMBL· GenBank· DDBJ | ASR14512.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645683 EMBL· GenBank· DDBJ | ASR14668.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645755 EMBL· GenBank· DDBJ | ASR15604.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645830 EMBL· GenBank· DDBJ | ASR16579.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645834 EMBL· GenBank· DDBJ | ASR16631.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645838 EMBL· GenBank· DDBJ | ASR16683.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645843 EMBL· GenBank· DDBJ | ASR16748.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645845 EMBL· GenBank· DDBJ | ASR16774.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645846 EMBL· GenBank· DDBJ | ASR16787.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645861 EMBL· GenBank· DDBJ | ASR16982.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645868 EMBL· GenBank· DDBJ | ASR17073.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645869 EMBL· GenBank· DDBJ | ASR17086.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645870 EMBL· GenBank· DDBJ | ASR17099.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645878 EMBL· GenBank· DDBJ | ASR17203.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645879 EMBL· GenBank· DDBJ | ASR17216.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645880 EMBL· GenBank· DDBJ | ASR17229.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645881 EMBL· GenBank· DDBJ | ASR17242.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645882 EMBL· GenBank· DDBJ | ASR17255.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645893 EMBL· GenBank· DDBJ | ASR17398.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645904 EMBL· GenBank· DDBJ | ASR17541.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645906 EMBL· GenBank· DDBJ | ASR17567.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645907 EMBL· GenBank· DDBJ | ASR17580.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645909 EMBL· GenBank· DDBJ | ASR17606.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645910 EMBL· GenBank· DDBJ | ASR17619.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645916 EMBL· GenBank· DDBJ | ASR17697.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645923 EMBL· GenBank· DDBJ | ASR17788.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645925 EMBL· GenBank· DDBJ | ASR17814.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645926 EMBL· GenBank· DDBJ | ASR17827.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680794 EMBL· GenBank· DDBJ | ASZ80423.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680795 EMBL· GenBank· DDBJ | ASZ80436.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680796 EMBL· GenBank· DDBJ | ASZ80449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680797 EMBL· GenBank· DDBJ | ASZ80462.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680798 EMBL· GenBank· DDBJ | ASZ80475.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680799 EMBL· GenBank· DDBJ | ASZ80488.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680800 EMBL· GenBank· DDBJ | ASZ80501.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680801 EMBL· GenBank· DDBJ | ASZ80514.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680802 EMBL· GenBank· DDBJ | ASZ80527.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680805 EMBL· GenBank· DDBJ | ASZ80566.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY681011 EMBL· GenBank· DDBJ | ASZ83244.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF152738 EMBL· GenBank· DDBJ | ATP84919.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT419161 EMBL· GenBank· DDBJ | QMP93626.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN857296 EMBL· GenBank· DDBJ | QTK14415.1 EMBL· GenBank· DDBJ | Genomic DNA |