A7X5P0 · A7X5P0_ORNAN

Function

function

Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

  • Cleavage of peptide bonds with very broad specificity.
    EC:3.4.25.1 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

127020406080100120140160180200220240260
TypeIDPosition(s)Description
Active site67Nucleophile

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular Componentproteasome core complex
Molecular Functionthreonine-type endopeptidase activity
Biological Processcell differentiation
Biological Processimmune system process
Biological Processproteolysis involved in protein catabolic process

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Proteasome subunit beta

Gene names

    • Name
      Psmb8

Organism names

Accessions

  • Primary accession
    A7X5P0

Subcellular Location

Keywords

Interaction

Subunit

Component of the proteasome complex.

Family & Domains

Sequence similarities

Belongs to the peptidase T1B family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    270
  • Mass (Da)
    29,686
  • Last updated
    2007-10-23 v1
  • Checksum
    5F7276E95DE2DD08
MALQQVCGPSPGWKDCLSSPPSLSGRSPFSSGTLDFEVPPGLQPSAFLKSLVGNRDDRVQIKLFKGTTTLAFNFQHGVVVAVDSRATAGNYICSQMVNKVIEINPQLLGTMSGSAADCQYWERLLAKECRLYHLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEDGVRLSGLMFSTGSGRNYAYGVMDSGYRYDLSPEEAYDLGRRAIVHATHRDGYSGGMVNMYHMKQDGWIKVEQTDVNDLLLSTLEARV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU030443
EMBL· GenBank· DDBJ
ABU86903.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp