A7UAK5 · A7UAK5_MOUSE
- Protein6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 splice variant 2
- GenePfkfb3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids555 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 253-260 | substrate | ||||
Sequence: RHGENEYN | ||||||
Active site | 254 | Tele-phosphohistidine intermediate | ||||
Sequence: H | ||||||
Active site | 323 | Proton donor/acceptor | ||||
Sequence: E |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleoplasm | |
Molecular Function | 6-phosphofructo-2-kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | fructose-2,6-bisphosphate 2-phosphatase activity | |
Biological Process | apoptotic process | |
Biological Process | fructose 2,6-bisphosphate metabolic process | |
Biological Process | fructose metabolic process | |
Biological Process | glial cell differentiation | |
Biological Process | glycolytic process | |
Biological Process | motor behavior |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA7UAK5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-246 | 6-phosphofructo-2-kinase | ||||
Sequence: SCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMRVRKQCALAALRDVKSYLTKEGGQIAVFDATNTTRERRHMILNFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRINCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQP | ||||||
Region | 474-504 | Disordered | ||||
Sequence: AKQDAKKGPNPLMRRNSVTPLASPEPTKKPR |
Sequence similarities
In the C-terminal section; belongs to the phosphoglycerate mutase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length555
- Mass (Da)63,653
- Last updated2007-10-02 v1
- Checksum89E9DFC05B01E508
Computationally mapped potential isoform sequences
There are 10 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A2AUP5 | A2AUP5_MOUSE | Pfkfb3 | 514 | ||
A2AUP3 | A2AUP3_MOUSE | Pfkfb3 | 513 | ||
A2AUP4 | A2AUP4_MOUSE | Pfkfb3 | 542 | ||
A2AUP1 | A2AUP1_MOUSE | Pfkfb3 | 520 | ||
Q3U3S6 | Q3U3S6_MOUSE | Pfkfb3 | 549 | ||
A0A0A6YW89 | A0A0A6YW89_MOUSE | Pfkfb3 | 327 | ||
A0A0A6YY64 | A0A0A6YY64_MOUSE | Pfkfb3 | 500 | ||
Q7TS91 | Q7TS91_MOUSE | Pfkfb3 | 526 | ||
A7UAK4 | A7UAK4_MOUSE | Pfkfb3 | 462 | ||
A7UAK8 | A7UAK8_MOUSE | Pfkfb3 | 543 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU034676 EMBL· GenBank· DDBJ | ABS88613.1 EMBL· GenBank· DDBJ | mRNA |