A7TNI7 · CHO21_VANPO

Function

function

Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).

Catalytic activity

Pathway

Phospholipid metabolism; phosphatidylcholine biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionphosphatidylethanolamine N-methyltransferase activity
Biological Processmethylation
Biological Processphosphatidylcholine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylethanolamine N-methyltransferase 1
  • EC number
  • Short names
    PE methyltransferase 1
    ; PEAMT 1
    ; PEMT 1

Gene names

    • Name
      CHO2-1
    • ORF names
      Kpol_1026p17

Organism names

Accessions

  • Primary accession
    A7TNI7

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-48Lumenal
Transmembrane49-69Helical
Topological domain70-73Cytoplasmic
Transmembrane74-94Helical
Topological domain95-157Lumenal
Transmembrane158-178Helical
Topological domain179-184Cytoplasmic
Transmembrane185-205Helical
Topological domain206-236Lumenal
Transmembrane237-257Helical
Topological domain258-261Cytoplasmic
Transmembrane262-282Helical
Topological domain283-328Lumenal
Transmembrane329-349Helical
Topological domain350-356Cytoplasmic
Transmembrane357-377Helical
Topological domain378-403Lumenal
Transmembrane404-424Helical
Topological domain425-435Cytoplasmic
Transmembrane436-456Helical
Topological domain457-517Lumenal
Transmembrane518-538Helical
Topological domain539-838Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004059221-838Phosphatidylethanolamine N-methyltransferase 1

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    838
  • Mass (Da)
    97,170
  • Last updated
    2007-10-02 v1
  • Checksum
    77E3412434F01038
MATEIITEKKEIVARTRSSGITFNPPVTHDMVRSLFDPTIKKSFLECCITLTILANFVLCYYLINWFGLSQAKLIFLIQYVYWRLAYNLGIGIILHYQSHYESLTKYANQNKLFKKESAKTNWIASFFQFEIKSKMPNDYNLHSYPDELNCWLLFRQFVDLILMQDFTTYIIYVYLSLPTDVSSLINWKSLIGIAMILFNIWVKIDAHRVVKDYAWYWGDFFFLQDAELTFDGVFNISPHPMYSIGYLGYYGLSLICGDYRVLLVSVGGHFLQFLFLKYVESPHIERTYGSDSPSNSTQHQIDDLIAKENYDYSRPLINTGILFENFQFLRFSDYFTVSTILVLFSWFFTSKPSNNFLFVLTLLTKLTTWLLTSWILFQQSNRKWFTRLFLKNGYTQIYSYQQWQFLYNYSLIVTNTLLFLHTLSELYSIQSSDGLNNSHVIFGLLLCAIQIWCNVETRDAISDFGWFYGDFFLTNYITTRKLTSQGIYRYLNNPEAILGVAGIWGSVLMTNFSKTNVTLAVLWTVTNLIFVKLIEEPHVSKVYGNGTRVSGVQQTLLALKPFRWISDLIDDWGNKMMKSLHGFDSDSDSESISSGKKGNLSSLKLSKKSKLKNRVQSDNKLAPNSKFEIEDLEDEIVYLPNSVTISWKLPISMFNEKDWIGLYNVLETGSDRTQTKIPSLGHWSAVDATGYPHDSINTNSITEFKKGSKNVSGRVTFDANLLYFKPGIYEFRYHSKNSHKVLLISSPFQISFPEFDNEAQVDIKNEIMKFLDAISCMKNEKYFANDNKYFTADAFSNYIKDSFGIELSTDYIRRVNGDVEVISRRVHDIKEVLDSLN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS480431
EMBL· GenBank· DDBJ
EDO16170.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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