A7TNI7 · CHO21_VANPO
- ProteinPhosphatidylethanolamine N-methyltransferase 1
- GeneCHO2-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids838 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H+ + S-adenosyl-L-homocysteine
Pathway
Phospholipid metabolism; phosphatidylcholine biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | phosphatidylethanolamine N-methyltransferase activity | |
Biological Process | methylation | |
Biological Process | phosphatidylcholine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylethanolamine N-methyltransferase 1
- EC number
- Short namesPE methyltransferase 1 ; PEAMT 1 ; PEMT 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Vanderwaltozyma
Accessions
- Primary accessionA7TNI7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-48 | Lumenal | ||||
Sequence: MATEIITEKKEIVARTRSSGITFNPPVTHDMVRSLFDPTIKKSFLECC | ||||||
Transmembrane | 49-69 | Helical | ||||
Sequence: ITLTILANFVLCYYLINWFGL | ||||||
Topological domain | 70-73 | Cytoplasmic | ||||
Sequence: SQAK | ||||||
Transmembrane | 74-94 | Helical | ||||
Sequence: LIFLIQYVYWRLAYNLGIGII | ||||||
Topological domain | 95-157 | Lumenal | ||||
Sequence: LHYQSHYESLTKYANQNKLFKKESAKTNWIASFFQFEIKSKMPNDYNLHSYPDELNCWLLFRQ | ||||||
Transmembrane | 158-178 | Helical | ||||
Sequence: FVDLILMQDFTTYIIYVYLSL | ||||||
Topological domain | 179-184 | Cytoplasmic | ||||
Sequence: PTDVSS | ||||||
Transmembrane | 185-205 | Helical | ||||
Sequence: LINWKSLIGIAMILFNIWVKI | ||||||
Topological domain | 206-236 | Lumenal | ||||
Sequence: DAHRVVKDYAWYWGDFFFLQDAELTFDGVFN | ||||||
Transmembrane | 237-257 | Helical | ||||
Sequence: ISPHPMYSIGYLGYYGLSLIC | ||||||
Topological domain | 258-261 | Cytoplasmic | ||||
Sequence: GDYR | ||||||
Transmembrane | 262-282 | Helical | ||||
Sequence: VLLVSVGGHFLQFLFLKYVES | ||||||
Topological domain | 283-328 | Lumenal | ||||
Sequence: PHIERTYGSDSPSNSTQHQIDDLIAKENYDYSRPLINTGILFENFQ | ||||||
Transmembrane | 329-349 | Helical | ||||
Sequence: FLRFSDYFTVSTILVLFSWFF | ||||||
Topological domain | 350-356 | Cytoplasmic | ||||
Sequence: TSKPSNN | ||||||
Transmembrane | 357-377 | Helical | ||||
Sequence: FLFVLTLLTKLTTWLLTSWIL | ||||||
Topological domain | 378-403 | Lumenal | ||||
Sequence: FQQSNRKWFTRLFLKNGYTQIYSYQQ | ||||||
Transmembrane | 404-424 | Helical | ||||
Sequence: WQFLYNYSLIVTNTLLFLHTL | ||||||
Topological domain | 425-435 | Cytoplasmic | ||||
Sequence: SELYSIQSSDG | ||||||
Transmembrane | 436-456 | Helical | ||||
Sequence: LNNSHVIFGLLLCAIQIWCNV | ||||||
Topological domain | 457-517 | Lumenal | ||||
Sequence: ETRDAISDFGWFYGDFFLTNYITTRKLTSQGIYRYLNNPEAILGVAGIWGSVLMTNFSKTN | ||||||
Transmembrane | 518-538 | Helical | ||||
Sequence: VTLAVLWTVTNLIFVKLIEEP | ||||||
Topological domain | 539-838 | Cytoplasmic | ||||
Sequence: HVSKVYGNGTRVSGVQQTLLALKPFRWISDLIDDWGNKMMKSLHGFDSDSDSESISSGKKGNLSSLKLSKKSKLKNRVQSDNKLAPNSKFEIEDLEDEIVYLPNSVTISWKLPISMFNEKDWIGLYNVLETGSDRTQTKIPSLGHWSAVDATGYPHDSINTNSITEFKKGSKNVSGRVTFDANLLYFKPGIYEFRYHSKNSHKVLLISSPFQISFPEFDNEAQVDIKNEIMKFLDAISCMKNEKYFANDNKYFTADAFSNYIKDSFGIELSTDYIRRVNGDVEVISRRVHDIKEVLDSLN |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000405922 | 1-838 | Phosphatidylethanolamine N-methyltransferase 1 | |||
Sequence: MATEIITEKKEIVARTRSSGITFNPPVTHDMVRSLFDPTIKKSFLECCITLTILANFVLCYYLINWFGLSQAKLIFLIQYVYWRLAYNLGIGIILHYQSHYESLTKYANQNKLFKKESAKTNWIASFFQFEIKSKMPNDYNLHSYPDELNCWLLFRQFVDLILMQDFTTYIIYVYLSLPTDVSSLINWKSLIGIAMILFNIWVKIDAHRVVKDYAWYWGDFFFLQDAELTFDGVFNISPHPMYSIGYLGYYGLSLICGDYRVLLVSVGGHFLQFLFLKYVESPHIERTYGSDSPSNSTQHQIDDLIAKENYDYSRPLINTGILFENFQFLRFSDYFTVSTILVLFSWFFTSKPSNNFLFVLTLLTKLTTWLLTSWILFQQSNRKWFTRLFLKNGYTQIYSYQQWQFLYNYSLIVTNTLLFLHTLSELYSIQSSDGLNNSHVIFGLLLCAIQIWCNVETRDAISDFGWFYGDFFLTNYITTRKLTSQGIYRYLNNPEAILGVAGIWGSVLMTNFSKTNVTLAVLWTVTNLIFVKLIEEPHVSKVYGNGTRVSGVQQTLLALKPFRWISDLIDDWGNKMMKSLHGFDSDSDSESISSGKKGNLSSLKLSKKSKLKNRVQSDNKLAPNSKFEIEDLEDEIVYLPNSVTISWKLPISMFNEKDWIGLYNVLETGSDRTQTKIPSLGHWSAVDATGYPHDSINTNSITEFKKGSKNVSGRVTFDANLLYFKPGIYEFRYHSKNSHKVLLISSPFQISFPEFDNEAQVDIKNEIMKFLDAISCMKNEKYFANDNKYFTADAFSNYIKDSFGIELSTDYIRRVNGDVEVISRRVHDIKEVLDSLN |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length838
- Mass (Da)97,170
- Last updated2007-10-02 v1
- Checksum77E3412434F01038
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS480431 EMBL· GenBank· DDBJ | EDO16170.1 EMBL· GenBank· DDBJ | Genomic DNA |