A7RNZ0 · NEP4_NEMVE
- ProteinNematocyst expressed protein 4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids370 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | nematocyst | |
Molecular Function | toxin activity |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameNematocyst expressed protein 4
- Short namesNEP-4 ; NEP4
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Cnidaria > Anthozoa > Hexacorallia > Actiniaria > Edwardsiidae > Nematostella
Accessions
- Primary accessionA7RNZ0
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MAWTLVLLVLLGTSSCLDA | ||||||
Chain | PRO_5002713691 | 20-370 | Nematocyst expressed protein 4 | |||
Sequence: KELHKKIDISALLESGSGSGEEGSSGSGSAPEPVRDQDVDWKQFKIKPEQCLDKGENCTGDPEQCQENWQEMVVQCPFSCRFCSQRSIDDVTECTDARGAACKDWADNRNDCLRFPQFMSTECTKSCKLCGKETNGKKFDKDVRCIEWAKNGYCNEGELYKEKCPHNCEVHKSIKKEPKGPYPYPTESLYPYQYWQLYPAPGPAPYPPYPYPTAAPYPYQYSPYPYTPYPPPPYPNPYPQPPYPPPPPPYPNPYPQPPYPPPPAPCSGPGPCPYPGPPPPPYPAPTPYPPPPPPYPEQVPPPPPPPPPPPPPPPYPYPYPYPDESENTKHKSKKHAKHHEKHHKENHSKKS | ||||||
Disulfide bond | 70↔102 | |||||
Sequence: CLDKGENCTGDPEQCQENWQEMVVQCPFSCRFC | ||||||
Disulfide bond | 77↔95 | |||||
Sequence: CTGDPEQCQENWQEMVVQC | ||||||
Disulfide bond | 84↔99 | |||||
Sequence: CQENWQEMVVQCPFSC | ||||||
Disulfide bond | 113↔149 | |||||
Sequence: CTDARGAACKDWADNRNDCLRFPQFMSTECTKSCKLC | ||||||
Disulfide bond | 121↔142 | |||||
Sequence: CKDWADNRNDCLRFPQFMSTEC | ||||||
Disulfide bond | 131↔146 | |||||
Sequence: CLRFPQFMSTECTKSC | ||||||
Disulfide bond | 164↔183 | |||||
Sequence: CIEWAKNGYCNEGELYKEKC | ||||||
Disulfide bond | 173↔187 | |||||
Sequence: CNEGELYKEKCPHNC |
Keywords
- PTM
Expression
Tissue specificity
Nematocytes (PubMed:23151943, PubMed:29424690).
In late planulae, transcripts are found throughout the ectoderm in nematocytes, with high concentration of expressing cells in the oral pole (PubMed:29424690).
In primary polyps, is expressed in nematocytes in the body wall and physa ectoderm and in the upper and lower pharynx (PubMed:29424690).
In late planulae, transcripts are found throughout the ectoderm in nematocytes, with high concentration of expressing cells in the oral pole (PubMed:29424690).
In primary polyps, is expressed in nematocytes in the body wall and physa ectoderm and in the upper and lower pharynx (PubMed:29424690).
Developmental stage
Transcripts are expressed in gastrulae, early and late planulae, metamorphosing planulae, and primary polyps.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 34-55 | Disordered | ||||
Sequence: SGSGSGEEGSSGSGSAPEPVRD | ||||||
Domain | 70-102 | ShKT 1 | ||||
Sequence: CLDKGENCTGDPEQCQENWQEMVVQCPFSCRFC | ||||||
Domain | 113-149 | ShKT 2 | ||||
Sequence: CTDARGAACKDWADNRNDCLRFPQFMSTECTKSCKLC | ||||||
Domain | 155-190 | ShKT 3 | ||||
Sequence: GKKFDKDVRCIEWAKNGYCNEGELYKEKCPHNCEVH | ||||||
Compositional bias | 306-340 | Pro residues | ||||
Sequence: PYPPPPPPYPEQVPPPPPPPPPPPPPPPYPYPYPY | ||||||
Region | 306-370 | Disordered | ||||
Sequence: PYPPPPPPYPEQVPPPPPPPPPPPPPPPYPYPYPYPDESENTKHKSKKHAKHHEKHHKENHSKKS | ||||||
Compositional bias | 350-370 | Basic residues | ||||
Sequence: KSKKHAKHHEKHHKENHSKKS |
Sequence similarities
Belongs to the NEP3 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length370
- Mass (Da)41,553
- Last updated2007-10-02 v1
- Checksum316E790BAF80DBEB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 306-340 | Pro residues | ||||
Sequence: PYPPPPPPYPEQVPPPPPPPPPPPPPPPYPYPYPY | ||||||
Compositional bias | 350-370 | Basic residues | ||||
Sequence: KSKKHAKHHEKHHKENHSKKS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS469524 EMBL· GenBank· DDBJ | EDO46764.1 EMBL· GenBank· DDBJ | Genomic DNA |