A7MET8 · LPXK_CROS8
- ProteinTetraacyldisaccharide 4'-kinase
- GenelpxK
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids325 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
Catalytic activity
- a lipid A disaccharide + ATP = a lipid IVA + ADP + H+
Pathway
Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 55-62 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | tetraacyldisaccharide 4'-kinase activity | |
Biological Process | lipid A biosynthetic process | |
Biological Process | lipopolysaccharide core region biosynthetic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTetraacyldisaccharide 4'-kinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Cronobacter
Accessions
- Primary accessionA7MET8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000123715 | 1-325 | Tetraacyldisaccharide 4'-kinase | ||
Structure
Sequence
- Sequence statusComplete
- Length325
- Mass (Da)35,205
- Last updated2007-10-02 v1
- ChecksumA012DD89731850EC
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000783 EMBL· GenBank· DDBJ | ABU77675.1 EMBL· GenBank· DDBJ | Genomic DNA |