A7MET8 · LPXK_CROS8

Function

function

Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

Catalytic activity

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.

Features

Showing features for binding site.

132550100150200250300
TypeIDPosition(s)Description
Binding site55-62ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functiontetraacyldisaccharide 4'-kinase activity
Biological Processlipid A biosynthetic process
Biological Processlipopolysaccharide core region biosynthetic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tetraacyldisaccharide 4'-kinase
  • EC number
  • Alternative names
    • Lipid A 4'-kinase

Gene names

    • Name
      lpxK
    • Ordered locus names
      ESA_02429

Organism names

Accessions

  • Primary accession
    A7MET8

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001237151-325Tetraacyldisaccharide 4'-kinase

Structure

Family & Domains

Sequence similarities

Belongs to the LpxK family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    325
  • Mass (Da)
    35,205
  • Last updated
    2007-10-02 v1
  • Checksum
    A012DD89731850EC
MIERIWSGCSLLWVLLLPLSWLYGLISGAIRLSYQLGLRKAWRAPVPVVVVGNLTAGGNGKTPVVVWLVEQLQQRGIRAGVVSRGYGGKAAHYPLVLNDATTPAEAGDEPVLIYQRTGAPVAVSANRAEAVQALMGHATPQIIITDDGLQHYALARDKEIVVVDGVRRFGNGWWLPAGPMRERASRLKQVDAVITNGGEARSGEIAMQLNPGLAVNLRSGEKRPVNTLNNVVAMAGIGHPPRFFATLEKCGLTPVKTVSLADHQALREADVLALLSEGQSLLMTEKDAVKCRAFAHDNWWYLPVDATLAQPQADQLLKDILTLVR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000783
EMBL· GenBank· DDBJ
ABU77675.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help