A7MBY6 · A7MBY6_DANRE
- ProteinCholine/ethanolaminephosphotransferase 1
- Genecept1b
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids415 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
Catalytic activity
- 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H+This reaction proceeds in the forward direction.
- 1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H+This reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Pathway
Lipid metabolism.
Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi apparatus | |
Cellular Component | nuclear membrane | |
Molecular Function | diacylglycerol cholinephosphotransferase activity | |
Molecular Function | ethanolaminephosphotransferase activity | |
Biological Process | phosphatidylethanolamine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCholine/ethanolaminephosphotransferase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA7MBY6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Nucleus membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 82-107 | Helical | ||||
Sequence: WIAPNLITIVGLVTNIFTTLVLVYYC | ||||||
Transmembrane | 114-132 | Helical | ||||
Sequence: APLWAYLLCAVGLFVYQSL | ||||||
Transmembrane | 181-201 | Helical | ||||
Sequence: WMFFCCFAGMFMFYCAHWQTY | ||||||
Transmembrane | 216-236 | Helical | ||||
Sequence: VQIFIILVYLLAAVGGSAFWQ | ||||||
Transmembrane | 248-266 | Helical | ||||
Sequence: IIPALCTFIGVVFSCTNYF | ||||||
Transmembrane | 286-304 | Helical | ||||
Sequence: VLSPVLHIGSVIILAMMIY | ||||||
Transmembrane | 316-336 | Helical | ||||
Sequence: PCLYILAFGFVSAKITNKLVV | ||||||
Transmembrane | 371-389 | Helical | ||||
Sequence: LVLWISLILSLFDLVRYCV |
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length415
- Mass (Da)46,201
- Last updated2007-10-02 v1
- Checksum05DAC580E794CA5F
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M9PRW3 | A0A8M9PRW3_DANRE | cept1b | 415 | ||
A0A8M3B557 | A0A8M3B557_DANRE | cept1b | 239 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU571313 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CU855600 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC151968 EMBL· GenBank· DDBJ | AAI51969.1 EMBL· GenBank· DDBJ | mRNA |