A7MBM2 · DISP2_HUMAN
- ProteinProtein dispatched homolog 2
- GeneDISP2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1401 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | transmembrane transporter activity | |
Biological Process | smoothened signaling pathway |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein dispatched homolog 2
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA7MBM2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 170-190 | Helical | ||||
Sequence: VAVLMLCLAVIFLCTLAGLLG | ||||||
Transmembrane | 484-504 | Helical | ||||
Sequence: FLVQDTVYPLLALVAIFFGMA | ||||||
Transmembrane | 510-530 | Helical | ||||
Sequence: LFLTLMVLLGVLGSLLVAFFL | ||||||
Transmembrane | 542-562 | Helical | ||||
Sequence: FVNLAALLLLSSVCANHTLIF | ||||||
Transmembrane | 589-609 | Helical | ||||
Sequence: FGYLLLVSGLTTSAAFYASYL | ||||||
Transmembrane | 617-637 | Helical | ||||
Sequence: CLALFMGTAVLVHLALTLVWL | ||||||
Transmembrane | 704-724 | Helical | ||||
Sequence: YIWICWFAALAAGGAYIAGVS | ||||||
Transmembrane | 964-984 | Helical | ||||
Sequence: PAVVLGLALALAFATLLLGTW | ||||||
Transmembrane | 990-1010 | Helical | ||||
Sequence: LFSVAAVAGTVLLTVGLLVLL | ||||||
Transmembrane | 1019-1039 | Helical | ||||
Sequence: ALFLSASVGLSVDFTVNYCIS | ||||||
Transmembrane | 1064-1084 | Helical | ||||
Sequence: AVGAAALFAAGVLMLPATVLL | ||||||
Transmembrane | 1088-1108 | Helical | ||||
Sequence: LGIILMMVKCVSCGFASFFFQ |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_037078 | 47 | in dbSNP:rs1898883 | |||
Sequence: P → A | ||||||
Natural variant | VAR_037079 | 56 | in dbSNP:rs1898882 | |||
Sequence: C → S | ||||||
Natural variant | VAR_037080 | 388 | in dbSNP:rs35043215 | |||
Sequence: G → E | ||||||
Natural variant | VAR_037081 | 1145 | in dbSNP:rs2412512 | |||
Sequence: G → S | ||||||
Natural variant | VAR_037082 | 1247 | in dbSNP:rs3743142 | |||
Sequence: R → W |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,596 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000310696 | 1-1401 | UniProt | Protein dispatched homolog 2 | |||
Sequence: MDGDSSSSSGGSGPAPGPGPEGEQRPEGEPLAPDGGSPDSTQTKAVPPEASPERSCSLHSCPLEDPSSSSGPPPTTSTLQPVGPSSPLAPAHFTYPRALQEYQGGSSLPGLGDRAALCSHGSSLSPSPAPSQRDGTWKPPAVQHHVVSVRQERAFQMPKSYSQLIAEWPVAVLMLCLAVIFLCTLAGLLGARLPDFSKPLLGFEPRDTDIGSKLVVWRALQALTGPRKLLFLSPDLELNSSSSHNTLRPAPRGSAQESAVRPRRMVEPLEDRRQENFFCGPPEKSYAKLVFMSTSSGSLWNLHAIHSMCRMEQDQIRSHTSFGALCQRTAANQCCPSWSLGNYLAVLSNRSSCLDTTQADAARTLALLRTCALYYHSGALVPSCLGPGQNKSPRCAQVPTKCSQSSAIYQLLHFLLDRDFLSPQTTDYQVPSLKYSLLFLPTPKGASLMDIYLDRLATPWGLADNYTSVTGMDLGLKQELLRHFLVQDTVYPLLALVAIFFGMALYLRSLFLTLMVLLGVLGSLLVAFFLYQVAFRMAYFPFVNLAALLLLSSVCANHTLIFFDLWRLSKSQLPSGGLAQRVGRTMHHFGYLLLVSGLTTSAAFYASYLSRLPAVRCLALFMGTAVLVHLALTLVWLPASAVLHERYLARGCARRARGRWEGSAPRRLLLALHRRLRGLRRAAAGTSRLLFQRLLPCGVIKFRYIWICWFAALAAGGAYIAGVSPRLRLPTLPPPGGQVFRPSHPFERFDAEYRQLFLFEQLPQGEGGHMPVVLVWGVLPVDTGDPLDPRSNSSLVRDPAFSASGPEAQRWLLALCHRARNQSFFDTLQEGWPTLCFVETLQRWMESPSCARLGPDLCCGHSDFPWAPQFFLHCLKMMALEQGPDGTQDLGLRFDAHGSLAALVLQFQTNFRNSPDYNQTQLFYNEVSHWLAAELGMAPPGLRRGWFTSRLELYSLQHSLSTEPAVVLGLALALAFATLLLGTWNVPLSLFSVAAVAGTVLLTVGLLVLLEWQLNTAEALFLSASVGLSVDFTVNYCISYHLCPHPDRLSRVAFSLRQTSCATAVGAAALFAAGVLMLPATVLLYRKLGIILMMVKCVSCGFASFFFQSLCCFFGPEKNCGQILWPCAHLPWDAGTGDPGGEKAGRPRPGSVGGMPGSCSEQYELQPLARRRSPSFDTSTATSKLSHRPSVLSEDLQLHDGPCCSRPPPAPASPRELLLDHQAVFSQCPALQTSSPYKQAGPSPKTRARQDSQGEEAEPLPASPEAPAHSPKAKAADPPDGFCSSASTLEGLSVSDETCLSTSEPSARVPDSVGVSPDDLDDTGQPVLERGQLNGKRDTLWLALRETVYDPSLPASHHSSLSWKGRGGPGDGSPVVLPNSQPDLPDVWLRRPSTHTSGYSS | |||||||
Glycosylation | 239 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 349 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 465 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue (large scale data) | 1173 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1175 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1235 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1252 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1263 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1270 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1366 | UniProt | Omega-N-methylarginine | ||||
Sequence: R | |||||||
Modified residue (large scale data) | 1373 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-91 | Disordered | ||||
Sequence: MDGDSSSSSGGSGPAPGPGPEGEQRPEGEPLAPDGGSPDSTQTKAVPPEASPERSCSLHSCPLEDPSSSSGPPPTTSTLQPVGPSSPLAPA | ||||||
Compositional bias | 61-84 | Polar residues | ||||
Sequence: CPLEDPSSSSGPPPTTSTLQPVGP | ||||||
Region | 113-138 | Disordered | ||||
Sequence: DRAALCSHGSSLSPSPAPSQRDGTWK | ||||||
Region | 241-264 | Disordered | ||||
Sequence: SSSHNTLRPAPRGSAQESAVRPRR | ||||||
Domain | 471-643 | SSD | ||||
Sequence: GMDLGLKQELLRHFLVQDTVYPLLALVAIFFGMALYLRSLFLTLMVLLGVLGSLLVAFFLYQVAFRMAYFPFVNLAALLLLSSVCANHTLIFFDLWRLSKSQLPSGGLAQRVGRTMHHFGYLLLVSGLTTSAAFYASYLSRLPAVRCLALFMGTAVLVHLALTLVWLPASAVL | ||||||
Region | 1169-1192 | Disordered | ||||
Sequence: ARRRSPSFDTSTATSKLSHRPSVL | ||||||
Compositional bias | 1172-1190 | Polar residues | ||||
Sequence: RSPSFDTSTATSKLSHRPS | ||||||
Compositional bias | 1229-1248 | Polar residues | ||||
Sequence: PALQTSSPYKQAGPSPKTRA | ||||||
Region | 1229-1337 | Disordered | ||||
Sequence: PALQTSSPYKQAGPSPKTRARQDSQGEEAEPLPASPEAPAHSPKAKAADPPDGFCSSASTLEGLSVSDETCLSTSEPSARVPDSVGVSPDDLDDTGQPVLERGQLNGKR | ||||||
Compositional bias | 1286-1309 | Polar residues | ||||
Sequence: ASTLEGLSVSDETCLSTSEPSARV | ||||||
Region | 1352-1401 | Disordered | ||||
Sequence: SLPASHHSSLSWKGRGGPGDGSPVVLPNSQPDLPDVWLRRPSTHTSGYSS |
Sequence similarities
Belongs to the dispatched family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,401
- Mass (Da)152,003
- Last updated2007-11-13 v2
- Checksum67BD27DC491C72CE
Sequence caution
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 61-84 | Polar residues | ||||
Sequence: CPLEDPSSSSGPPPTTSTLQPVGP | ||||||
Sequence conflict | 67 | in Ref. 1; BAB21833 | ||||
Sequence: S → F | ||||||
Sequence conflict | 70 | in Ref. 1; BAB21833 | ||||
Sequence: S → L | ||||||
Sequence conflict | 77 | in Ref. 1; BAB21833 | ||||
Sequence: S → F | ||||||
Sequence conflict | 96 | in Ref. 1; BAB21833 | ||||
Sequence: P → T | ||||||
Compositional bias | 1172-1190 | Polar residues | ||||
Sequence: RSPSFDTSTATSKLSHRPS | ||||||
Compositional bias | 1229-1248 | Polar residues | ||||
Sequence: PALQTSSPYKQAGPSPKTRA | ||||||
Compositional bias | 1286-1309 | Polar residues | ||||
Sequence: ASTLEGLSVSDETCLSTSEPSARV |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB051529 EMBL· GenBank· DDBJ | BAB21833.2 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AC013356 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC151833 EMBL· GenBank· DDBJ | AAI51834.1 EMBL· GenBank· DDBJ | mRNA | ||
CR627480 EMBL· GenBank· DDBJ | CAH10680.1 EMBL· GenBank· DDBJ | mRNA |