A7LCJ2 · PA2_URTCR

Function

function

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Miscellaneous

Lacks hemolytic activity on bovine red blood cells as well as neurotoxic activities.
mRNA is obtained from a single animal, whereas the protein is isolated from exudates of several specimens.

Caution

Possesses an Asp at position 69 instead of a conserved Cys.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site72Ca2+ (UniProtKB | ChEBI)
Binding site74Ca2+ (UniProtKB | ChEBI)
Active site90
Binding site91Ca2+ (UniProtKB | ChEBI)
Active site137

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componentnematocyst
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent phospholipase A2 activity
Molecular Functionphospholipid binding
Molecular Functiontoxin activity
Biological Processarachidonic acid secretion
Biological Processlipid catabolic process
Biological Processphospholipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipase A2 A2-actitoxin-Ucs2a
  • EC number
  • Short names
    A2-AITX-Ucs2a
  • Alternative names
    • Phosphatidylcholine 2-acylhydrolase
    • UcPLA2

Organism names

Accessions

  • Primary accession
    A7LCJ2

Subcellular Location

PTM/Processing

Features

Showing features for signal, propeptide, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-19
PropeptidePRO_000041379820-42
ChainPRO_000041379945-155Phospholipase A2 A2-actitoxin-Ucs2a
Disulfide bond55↔118
Disulfide bond71↔87
Disulfide bond86↔143
Disulfide bond93↔136
Disulfide bond100↔129
Disulfide bond122↔134

Keywords

Structure

Family & Domains

Sequence similarities

Belongs to the phospholipase A2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    155
  • Mass (Da)
    17,319
  • Last updated
    2007-09-11 v1
  • Checksum
    D4C567640BA93626
MKNNIILVILLGISVFVDCLPLNDQEEDKSLNAQESEVSAVQKRDILQFSGMIRCATGRSAWKYFNYGNWCGWGGSGTAVDGVDSCCRSHDWCYKRHDSCYPKIIPYIASTSGSHPSCSITCHSANNRCQRDVCNCDKVAAECFARNTYHPNNKH

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict45-46in Ref. 1; AA sequence
Sequence conflict51in Ref. 1; AA sequence
Sequence conflict54in Ref. 1; AA sequence
Sequence conflict65in Ref. 1; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU003992
EMBL· GenBank· DDBJ
ABS19666.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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