A7KNZ4 · A7KNZ4_NEUCS

  • Protein
    cAMP-dependent protein kinase regulatory subunit
  • Gene
    mcb
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

Features

Showing features for binding site.

138550100150200250300350
TypeIDPosition(s)Description
Binding site2073',5'-cyclic AMP 1 (UniProtKB | ChEBI)
Binding site2163',5'-cyclic AMP 1 (UniProtKB | ChEBI)
Binding site3283',5'-cyclic AMP 2 (UniProtKB | ChEBI)
Binding site3373',5'-cyclic AMP 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentcAMP-dependent protein kinase complex
Cellular Componentnucleus
Molecular FunctioncAMP binding
Molecular FunctioncAMP-dependent protein kinase inhibitor activity
Molecular Functionkinase activity
Molecular Functionprotein kinase A catalytic subunit binding
Biological Processnegative regulation of cAMP-dependent protein kinase activity
Biological Processphosphorylation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    cAMP-dependent protein kinase regulatory subunit

Gene names

    • Name
      mcb
    • Synonyms
      PKAR

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Sordariaceae > Neurospora

Accessions

  • Primary accession
    A7KNZ4

Organism-specific databases

PTM/Processing

Keywords

Interaction

Subunit

Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-21Polar residues
Region1-51Disordered
Region77-111Disordered
Compositional bias87-109Polar residues
Domain129-258Cyclic nucleotide-binding
Domain261-370Cyclic nucleotide-binding

Sequence similarities

Belongs to the cAMP-dependent kinase regulatory chain family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    385
  • Mass (Da)
    42,156
  • Last updated
    2007-09-11 v1
  • Checksum
    4B3F52B7486735D4
MSSTGFTSPFGNANPFGSSGRSESGPMHRLVEEDENDTITSPTTPHFGVKNNAAPAFWNGFGGDAPSDMPVRRQPDDFPAHYNLGRRTSVSAESLKPVTDNSDNWSPPVHPKTAEQLERLKKAISGNFLFNHLEDDQSAQVLGALVEKPVPAKGIKVITQGDAGDYFYVVEKGRFEVYVNSTGALQPGPDGMGQKVGEIAEGGSFGELALMYNAPRAATVVSAEPQCTLWALDRVTFRRILMESTFSRRRMYESFLEEVPILKTLTPYERSKIADALESQKYPAGHEIILEGDPGHSFFLLEAGEAAAFKRGNDSPVKNYKKGDFFGELALLNDAPRAASVISQTEVKVARLGKNAFQRLLGPIESILRRTRYVEAEEVDPLQVS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-21Polar residues
Compositional bias87-109Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF495262
EMBL· GenBank· DDBJ
ABS50108.1
EMBL· GenBank· DDBJ
Genomic DNA
EU478696
EMBL· GenBank· DDBJ
ACA48491.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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