A7KNZ4 · A7KNZ4_NEUCS
- ProteincAMP-dependent protein kinase regulatory subunit
- Genemcb
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids385 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cAMP-dependent protein kinase complex | |
Cellular Component | nucleus | |
Molecular Function | cAMP binding | |
Molecular Function | cAMP-dependent protein kinase inhibitor activity | |
Molecular Function | kinase activity | |
Molecular Function | protein kinase A catalytic subunit binding | |
Biological Process | negative regulation of cAMP-dependent protein kinase activity | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended namecAMP-dependent protein kinase regulatory subunit
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Sordariaceae > Neurospora
Accessions
- Primary accessionA7KNZ4
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | ||||
Sequence: MSSTGFTSPFGNANPFGSSGR | ||||||
Region | 1-51 | Disordered | ||||
Sequence: MSSTGFTSPFGNANPFGSSGRSESGPMHRLVEEDENDTITSPTTPHFGVKN | ||||||
Region | 77-111 | Disordered | ||||
Sequence: DFPAHYNLGRRTSVSAESLKPVTDNSDNWSPPVHP | ||||||
Compositional bias | 87-109 | Polar residues | ||||
Sequence: RTSVSAESLKPVTDNSDNWSPPV | ||||||
Domain | 129-258 | Cyclic nucleotide-binding | ||||
Sequence: LFNHLEDDQSAQVLGALVEKPVPAKGIKVITQGDAGDYFYVVEKGRFEVYVNSTGALQPGPDGMGQKVGEIAEGGSFGELALMYNAPRAATVVSAEPQCTLWALDRVTFRRILMESTFSRRRMYESFLEE | ||||||
Domain | 261-370 | Cyclic nucleotide-binding | ||||
Sequence: ILKTLTPYERSKIADALESQKYPAGHEIILEGDPGHSFFLLEAGEAAAFKRGNDSPVKNYKKGDFFGELALLNDAPRAASVISQTEVKVARLGKNAFQRLLGPIESILRR |
Sequence similarities
Belongs to the cAMP-dependent kinase regulatory chain family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length385
- Mass (Da)42,156
- Last updated2007-09-11 v1
- Checksum4B3F52B7486735D4
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | ||||
Sequence: MSSTGFTSPFGNANPFGSSGR | ||||||
Compositional bias | 87-109 | Polar residues | ||||
Sequence: RTSVSAESLKPVTDNSDNWSPPV |