A7H0K4 · DXR_CAMC5

Function

function

Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site7NADPH (UniProtKB | ChEBI)
Binding site8NADPH (UniProtKB | ChEBI)
Binding site9NADPH (UniProtKB | ChEBI)
Binding site10NADPH (UniProtKB | ChEBI)
Binding site31NADPH (UniProtKB | ChEBI)
Binding site32NADPH (UniProtKB | ChEBI)
Binding site33NADPH (UniProtKB | ChEBI)
Binding site114NADPH (UniProtKB | ChEBI)
Binding site1151-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site116NADPH (UniProtKB | ChEBI)
Binding site134Mn2+ (UniProtKB | ChEBI)
Binding site1351-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1361-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site136Mn2+ (UniProtKB | ChEBI)
Binding site1581-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1811-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site187NADPH (UniProtKB | ChEBI)
Binding site1941-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1991-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2001-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2031-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site203Mn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Molecular Functionmetal ion binding
Molecular FunctionNADPH binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • EC number
  • Short names
    DXP reductoisomerase
  • Alternative names
    • 1-deoxyxylulose-5-phosphate reductoisomerase
    • 2-C-methyl-D-erythritol 4-phosphate synthase

Gene names

    • Name
      dxr
    • ORF names
      CCV52592_0594
    • Ordered locus names
      Ccur92_16920

Organism names

Accessions

  • Primary accession
    A7H0K4

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000202361-3651-deoxy-D-xylulose 5-phosphate reductoisomerase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the DXR family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    39,640
  • Last updated
    2007-09-11 v1
  • Checksum
    E941E52D95598B93
MVILGSTGSIGTNTLEICSRHGVSVEALSCAKNIALLNEQIARFRPKFVCVADESLASEVKILKKSQIFVGAGGLLEMLEACHSQKVVNAIVGFAGLAPSLKTQELGKSLALANKESLVAGGKFLDTAKISPIDSEHFGLKFLLQNRTAPNRLIITASGGAFYRTPMKNLAKVTPSDALKHPNWSMGAKITIDSATMANKLFEVMEAFWLYGTSRIDALIEPTSMVHALVEFMDGSCTAHISRADMKLAIAHAVLENVSENVVAHADLLALKDIKFHKINLKKYPIFSLKEQVLERADLGVVINAANEVGVFAFLKGECRFLDISRIVLAAAKRFADVKIETKDEIFAIDAEVRNFTKRGLNAKI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000767
EMBL· GenBank· DDBJ
EAU01416.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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