A7F6C1 · MIC60_SCLS1

Function

function

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentMICOS complex
Biological Processcristae formation

Names & Taxonomy

Protein names

  • Recommended name
    MICOS complex subunit mic60
  • Alternative names
    • Mitofilin

Gene names

    • Name
      mic60
    • ORF names
      SS1G_13150

Organism names

Accessions

  • Primary accession
    A7F6C1

Proteomes

Subcellular Location

Mitochondrion inner membrane
; Single-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain41-129Mitochondrial matrix
Transmembrane130-149Helical
Topological domain150-659Mitochondrial intermembrane

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain.

TypeIDPosition(s)Description
Transit peptide1-40Mitochondrion
ChainPRO_000040667341-659MICOS complex subunit mic60

Interaction

Subunit

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Region41-123Disordered
Compositional bias76-92Polar residues
Compositional bias93-121Pro residues
Region187-290Disordered
Compositional bias199-215Polar residues
Compositional bias216-251Basic and acidic residues
Coiled coil403-458

Sequence similarities

Belongs to the MICOS complex subunit Mic60 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    659
  • Mass (Da)
    72,575
  • Last updated
    2007-09-11 v1
  • Checksum
    97C6BCB0F9C15FE5
MLRAGLRSSRALGLRPNVVSPGRQWRAQNARVISDTMRTFADKSSISDSRPPVLPGSASEATSEPLPPGAVATPNSAAPTPATPTSSTIPAENVPLTPPPPGVQSPGPPPPSSSPPPPAPKPKRRFFRKFFTTLFLLTTLGFGGGVYYSRINDNFHDFFTEYVPFGEDAVLYFEEQEFRKRFPLISSRASRPPRDTGEQVKIPSQSGVSWRVANENKDSTGRHTSSAKDKVKPSEAVQTPHDSKPADRVKAVEQVKSGNSPVKNSPAPPATPESKPSNVQKDPEVNEPSRAYKKIERIDPINIPNGNEPVVQELVKIMNDIIAVVNADNANARFTSTMDKAKAELNRVGAKILDMKDAALKQADEKIKSSDAEFDRAAMQLMQNFKNQQAEQEAQFRAEYEAERKRIHENYEQKLKSELDRANEVNEKTLQNNLTEQALELKRAFLADVKNRVEQEREGRLGKLSELTSTVNDLEKLTGDFNTVVDQNLKTQHLHVAVEAVRANLEKSQIPRPFTRELAALKEIASDDPVVNAAIASINPVAYQKGVPSSAALIDRFRRVASEVRKASLLPEEAGVASHASSYVLSKLLFKKKGLATGDDVESILTRTETFLEEGDLDGAAREMNGLKGWAKTLSKDWLGEVRKVLEVQQALDKPDYKV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias76-92Polar residues
Compositional bias93-121Pro residues
Compositional bias199-215Polar residues
Compositional bias216-251Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH476643
EMBL· GenBank· DDBJ
EDN98292.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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