A7EM78 · DBP9_SCLS1
- ProteinATP-dependent RNA helicase dbp9
- Genedbp9
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids607 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleolus | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Biological Process | rRNA processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent RNA helicase dbp9
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Helotiales > Sclerotiniaceae > Sclerotinia
Accessions
- Primary accessionA7EM78
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000310256 | 1-607 | ATP-dependent RNA helicase dbp9 | |||
Sequence: MKRKLDVNDVPVPTEEAEAANGKATFASLGLDARLLQGIAKQNFQSPTLVQSKAIPLTLEGRDILARAKTGSGKTAAYLLPILHSILKRKELSPTQCTSALILVPTRELADQVYKTVESFTAFCAKDVRAVNLTQRVSDAVQRSLLADSPDIVIATPARASLNANTSALLLTNLTHMVIDEADLVLSYGYDEDLQNVAKIMPKGVQTVLMSATLTSEVETLKGLFCRNPEVLKLEEAEDEGKGVSQFVVKCAEDEKFLLVYVIFKLKLIKGKCIIFVGDIDRCYRLKLFLEQFGTRSCILNSQLPVNSRIHVVEEFNKNVYDIIIASDEHEVLGDEDEPKPEETEEVEADDASGEKEDAKDAKKETKQPSKKKQKTGKKDKEYGVSRGIDFKNVACVLNFDLPTSSKSYTHRIGRTARAGQTGMALSFVIPSALYRKHKPTSIESAKDDEKVLAKIIKHQAKKGKEVKPYNFDMKQVDAFRYRMGDALRAVTSIAVQEAKAREIRQELMKSEKLKRHFEENPSDLYHLRHDGELRPARVQAHLKHVPDYLLPKEGKKGITGGDIGFVGMHKTTENRIRKARAANKAKGRGKGRKSDPLKTFKAKSRK |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for motif, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 24-52 | Q motif | ||||
Sequence: ATFASLGLDARLLQGIAKQNFQSPTLVQS | ||||||
Domain | 55-232 | Helicase ATP-binding | ||||
Sequence: IPLTLEGRDILARAKTGSGKTAAYLLPILHSILKRKELSPTQCTSALILVPTRELADQVYKTVESFTAFCAKDVRAVNLTQRVSDAVQRSLLADSPDIVIATPARASLNANTSALLLTNLTHMVIDEADLVLSYGYDEDLQNVAKIMPKGVQTVLMSATLTSEVETLKGLFCRNPEVL | ||||||
Motif | 180-183 | DEAD box | ||||
Sequence: DEAD | ||||||
Domain | 243-475 | Helicase C-terminal | ||||
Sequence: GVSQFVVKCAEDEKFLLVYVIFKLKLIKGKCIIFVGDIDRCYRLKLFLEQFGTRSCILNSQLPVNSRIHVVEEFNKNVYDIIIASDEHEVLGDEDEPKPEETEEVEADDASGEKEDAKDAKKETKQPSKKKQKTGKKDKEYGVSRGIDFKNVACVLNFDLPTSSKSYTHRIGRTARAGQTGMALSFVIPSALYRKHKPTSIESAKDDEKVLAKIIKHQAKKGKEVKPYNFDMK | ||||||
Region | 332-380 | Disordered | ||||
Sequence: VLGDEDEPKPEETEEVEADDASGEKEDAKDAKKETKQPSKKKQKTGKKD | ||||||
Compositional bias | 335-352 | Acidic residues | ||||
Sequence: DEDEPKPEETEEVEADDA | ||||||
Compositional bias | 353-368 | Basic and acidic residues | ||||
Sequence: SGEKEDAKDAKKETKQ | ||||||
Region | 580-607 | Disordered | ||||
Sequence: ARAANKAKGRGKGRKSDPLKTFKAKSRK |
Domain
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence similarities
Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length607
- Mass (Da)67,588
- Last updated2007-09-11 v1
- Checksum490FC03B7F5F0E35
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 335-352 | Acidic residues | ||||
Sequence: DEDEPKPEETEEVEADDA | ||||||
Compositional bias | 353-368 | Basic and acidic residues | ||||
Sequence: SGEKEDAKDAKKETKQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH476628 EMBL· GenBank· DDBJ | EDO03944.1 EMBL· GenBank· DDBJ | Genomic DNA |