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A7EFH4 · MPH1_SCLS1

Function

function

ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.

Catalytic activity

Features

Showing features for binding site.

112351002003004005006007008009001,0001,1001,200
TypeIDPosition(s)Description
Binding site285-292ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Function3'-5' DNA helicase activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionfour-way junction DNA binding
Molecular Functionfour-way junction helicase activity
Biological Processdouble-strand break repair via synthesis-dependent strand annealing
Biological Processinterstrand cross-link repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent DNA helicase mph1
  • EC number
  • Alternative names
    • FANCM-like protein 1

Gene names

    • Name
      mph1
    • ORF names
      SS1G_04065

Organism names

Accessions

  • Primary accession
    A7EFH4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003333801-1235ATP-dependent DNA helicase mph1

Interaction

Subunit

Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain, motif.

Type
IDPosition(s)Description
Region20-78Disordered
Compositional bias37-78Basic and acidic residues
Region96-148Disordered
Compositional bias123-148Polar residues
Domain272-440Helicase ATP-binding
Motif388-391DEAH box
Domain608-784Helicase C-terminal
Region808-827Disordered
Region944-1117Disordered
Compositional bias945-959Basic and acidic residues
Compositional bias1034-1058Polar residues
Compositional bias1061-1075Basic and acidic residues
Compositional bias1091-1116Polar residues
Region1144-1235Disordered
Compositional bias1146-1167Polar residues
Compositional bias1176-1208Polar residues
Compositional bias1210-1235Basic and acidic residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,235
  • Mass (Da)
    137,407
  • Last updated
    2007-09-11 v1
  • MD5 Checksum
    43870458B9C2629A91A15A432ADA4BD0
MSDDEYGDIDAAVWDEAEALTQASQTLPSNFPHRRKRRRIGSEELDDGFLSGRRRGSHGFSRSDNDEADEKKSKYRIHLGAEEVPAAVIMGATQADEMPDSSPYRIRGPIYKRPRRSPPMELEQKSSPAQPSMVESAKTQKQNIVHSPQPTAQYDFSRELEDLPSDAFSPSPPQLRMSSIPITISSSPPLESTQSVRSQRLAAPQNGLRQTTLFGGRAPNQVPSSTQAKKVHKYLVDKVPEPPTHHTLDEEAIKTWIYPNNLGAERRYQYTIVHKGLFNNLLVALPTGLGKTFIAATIMLNFFRWTTDSQIVFMAPTKPLVSQQVKACFEIAGIPRSSTTMLTGDQSPALRAEEWAEKRVFFMTPQTVENDLKTGIADPKKIALIVVDEAHRATGNYAYTKVVQFLRRFNESFRVLALTATPGSSVEAVQEVIDNLEIAEVEIRTEDSIDIKEYVHRRDITEILIDPSDEIIMIRELFSKALQPLVNLLCSQKAYYNKDPMGLTQYGMLTARKAWMASGAGKSAQMSIKGMMNALFTVLTSMGHAIKLLNFHGIGPFFSNIKDFRAEVEGNKKGGKYKNQIVNSPEFKKMMERIQGWINKEDFIGHPKLTYLCDTVLNHFLDAGAGLMGDNMPPSSTRVIVFTEYRDSAEDIARVLNKHGPMIRASVFVGQSDSKRSEGMNQEKQLETIRKFKAGGINVIVATSIGEEGLDIGEVDLIVCYDSSSSPIRMLQRMGRTGRKRAGKIVLLLMRGKEEDSYKKSKDNYEQIQRMISSGSRFTFRHDLSARIIPRKVKPEVDKRFIEIPLENTQDPSLPEPKRRAKPRKKLAKKFHMPDGVETGFRKASKLNSNAESPLTKFGIKRKPSELNDDELAPVPLLDSVLLNAKDEAEHSRRFLKVPDGALEEVGMPDLTAQPITQRTLTRTAKVSHGKYTRSCVSLFNKLSRLQRPEDRDNKPYGDEPPSDFGSIPTMPLEAEVRARAPKAPKASDPAQVVKASRVAKTTSALKKAPASKRVAPKKAKPRRGRALRNDNSDSEDSTASMAMVSNLRSSQIPQPTPDSDEEGPGERVDRTSDMEELEADDDSDLGSLVDFIDPTQTQTQIPLTGTSNFSSSPPLMETWEDERINGNAVGGRRGMLPRAVEMTGAKNSSFKNGTMTQESSDGGDSMDSDFPTIEDLVRSDTTTTTTRKIADPPSSSVFSSGQKATPNMFTRKRDGDVRGRGLKRRVVESDDSDE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias37-78Basic and acidic residues
Compositional bias123-148Polar residues
Compositional bias945-959Basic and acidic residues
Compositional bias1034-1058Polar residues
Compositional bias1061-1075Basic and acidic residues
Compositional bias1091-1116Polar residues
Compositional bias1146-1167Polar residues
Compositional bias1176-1208Polar residues
Compositional bias1210-1235Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH476625
EMBL· GenBank· DDBJ
EDO01590.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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