A7EFH4 · MPH1_SCLS1
- ProteinATP-dependent DNA helicase mph1
- Genemph1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1235 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 285-292 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | 3'-5' DNA helicase activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | four-way junction DNA binding | |
Molecular Function | four-way junction helicase activity | |
Biological Process | double-strand break repair via synthesis-dependent strand annealing | |
Biological Process | interstrand cross-link repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent DNA helicase mph1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Helotiales > Sclerotiniaceae > Sclerotinia
Accessions
- Primary accessionA7EFH4
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000333380 | 1-1235 | ATP-dependent DNA helicase mph1 | ||
Interaction
Subunit
Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 20-78 | Disordered | |||
Compositional bias | 37-78 | Basic and acidic residues | |||
Region | 96-148 | Disordered | |||
Compositional bias | 123-148 | Polar residues | |||
Domain | 272-440 | Helicase ATP-binding | |||
Motif | 388-391 | DEAH box | |||
Domain | 608-784 | Helicase C-terminal | |||
Region | 808-827 | Disordered | |||
Region | 944-1117 | Disordered | |||
Compositional bias | 945-959 | Basic and acidic residues | |||
Compositional bias | 1034-1058 | Polar residues | |||
Compositional bias | 1061-1075 | Basic and acidic residues | |||
Compositional bias | 1091-1116 | Polar residues | |||
Region | 1144-1235 | Disordered | |||
Compositional bias | 1146-1167 | Polar residues | |||
Compositional bias | 1176-1208 | Polar residues | |||
Compositional bias | 1210-1235 | Basic and acidic residues | |||
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,235
- Mass (Da)137,407
- Last updated2007-09-11 v1
- MD5 Checksum43870458B9C2629A91A15A432ADA4BD0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 37-78 | Basic and acidic residues | |||
Compositional bias | 123-148 | Polar residues | |||
Compositional bias | 945-959 | Basic and acidic residues | |||
Compositional bias | 1034-1058 | Polar residues | |||
Compositional bias | 1061-1075 | Basic and acidic residues | |||
Compositional bias | 1091-1116 | Polar residues | |||
Compositional bias | 1146-1167 | Polar residues | |||
Compositional bias | 1176-1208 | Polar residues | |||
Compositional bias | 1210-1235 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH476625 EMBL· GenBank· DDBJ | EDO01590.1 EMBL· GenBank· DDBJ | Genomic DNA |