A7E7N7 · END3_SCLS1
- ProteinActin cytoskeleton-regulatory complex protein end3
- Geneend3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids400 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 55 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 57 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 59 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 61 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 66 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | actin cortical patch | |
Cellular Component | cytoplasm | |
Cellular Component | endosome membrane | |
Cellular Component | plasma membrane | |
Molecular Function | actin binding | |
Molecular Function | calcium ion binding | |
Biological Process | actin filament organization | |
Biological Process | endocytosis | |
Biological Process | endosomal transport |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameActin cytoskeleton-regulatory complex protein end3
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Helotiales > Sclerotiniaceae > Sclerotinia
Accessions
- Primary accessionA7E7N7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Endosome membrane ; Peripheral membrane protein
Note: Cytoplasmic and cortical actin patches.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000349458 | 1-400 | Actin cytoskeleton-regulatory complex protein end3 | ||
Interaction
Subunit
Component of the PAN1 actin cytoskeleton-regulatory complex.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 10-100 | EH 1 | |||
Domain | 42-77 | EF-hand | |||
Domain | 139-223 | EH 2 | |||
Coiled coil | 286-400 | ||||
Sequence similarities
Belongs to the END3 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length400
- Mass (Da)44,953
- Last updated2007-09-11 v1
- Checksum18C8AC409C416E47
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH476622 EMBL· GenBank· DDBJ | EDN96389.1 EMBL· GenBank· DDBJ | Genomic DNA |