A7E7N7 · END3_SCLS1

Function

function

Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).

Features

Showing features for binding site.

140050100150200250300350400
TypeIDPosition(s)Description
Binding site55Ca2+ (UniProtKB | ChEBI)
Binding site57Ca2+ (UniProtKB | ChEBI)
Binding site59Ca2+ (UniProtKB | ChEBI)
Binding site61Ca2+ (UniProtKB | ChEBI)
Binding site66Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentactin cortical patch
Cellular Componentcytoplasm
Cellular Componentendosome membrane
Cellular Componentplasma membrane
Molecular Functionactin binding
Molecular Functioncalcium ion binding
Biological Processactin filament organization
Biological Processendocytosis
Biological Processendosomal transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Actin cytoskeleton-regulatory complex protein end3
  • Alternative names
    • Endocytosis protein 3

Gene names

    • Name
      end3
    • ORF names
      SS1G_01315

Organism names

Accessions

  • Primary accession
    A7E7N7

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Peripheral membrane protein
Endosome membrane
; Peripheral membrane protein
Note: Cytoplasmic and cortical actin patches.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003494581-400Actin cytoskeleton-regulatory complex protein end3

Interaction

Subunit

Component of the PAN1 actin cytoskeleton-regulatory complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, coiled coil.

Type
IDPosition(s)Description
Domain10-100EH 1
Domain42-77EF-hand
Domain139-223EH 2
Coiled coil286-400

Sequence similarities

Belongs to the END3 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    400
  • Mass (Da)
    44,953
  • Last updated
    2007-09-11 v1
  • Checksum
    18C8AC409C416E47
MSNKRIEQSEIEKYWEIFASLSNGGTHLTGAQAAPVLKNSQLRDDQLERIWDLADVDNDGNLDFEEFCVAMRLIFDLVNGEYADVPPALPDWLVPESKAHLVQASRALTGRQVQFERVEDDDDTPGLKDGFDWYMSPSDKSKYEEIYAANRDGRGDITYTLYSSLDVPDTDVRSAWNLINPSAAPAISKDATLAFLHILNNRHEGYRIPRTVPPSLRASFERNQIDYQLDNQRVASPAQKWGVTGGEETSTGRKAKFGETYMSRLGLGGKSSYRPAGTDFSGTKTTEDWEEVRLKKQLAELEAKIEKVEAAAAARSGGRRDTKPALVKRELEQLLDYKRRELRDLESGEGRSKVGASLKGVADEIATVREQVDGLEAHLRSREQVLEELKQEIENEKISR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH476622
EMBL· GenBank· DDBJ
EDN96389.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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