A7E2Y1 · MYH7B_HUMAN
- ProteinMyosin-7B
- GeneMYH7B
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1983 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in muscle contraction.
Miscellaneous
Expression does not vary in normal patients compared to patients with acute monocytic leukemia.
The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Cellular Component | myosin filament | |
Cellular Component | myosin II complex | |
Molecular Function | actin filament binding | |
Molecular Function | ATP binding | |
Molecular Function | microfilament motor activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMyosin-7B
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA7E2Y1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_046359 | 70 | in dbSNP:rs17092199 | |||
Sequence: P → T | ||||||
Natural variant | VAR_046360 | 501 | in dbSNP:rs754511 | |||
Sequence: F → Y | ||||||
Natural variant | VAR_046361 | 780 | in dbSNP:rs3746442 | |||
Sequence: P → S | ||||||
Natural variant | VAR_054814 | 1007 | in dbSNP:rs2425015 | |||
Sequence: E → K | ||||||
Natural variant | VAR_046362 | 1552 | in dbSNP:rs3746435 | |||
Sequence: K → N | ||||||
Natural variant | VAR_046363 | 1581 | in dbSNP:rs6060147 | |||
Sequence: A → V | ||||||
Natural variant | VAR_046364 | 1698 | in dbSNP:rs6060148 | |||
Sequence: Q → R | ||||||
Natural variant | VAR_046365 | 1917 | in dbSNP:rs7273482 | |||
Sequence: V → E |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 8 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000349312 | 1-1983 | UniProt | Myosin-7B | |||
Sequence: MSGNKRGSRASCPHRGAECLLPWAALNLQGFQLLLLHPSATAMMDVSELGESARYLRQGYQEMTKVHTIPWDGKKRVWVPDEQDAYVEAEVKSEATGGRVTVETKDQKVLMVREAELQPMNPPRFDLLEDMAMMTHLNEASVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTASVVAAYKGKRRSDSPPHIYAVADNAYNDMLRNRDNQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGKKAQFLATKTGGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPSGKLASADIDSYLLEKSRVIFQLPGERSYHVYYQILSGRKPELQDMLLLSMNPYDYHFCSQGVITVDNMNDGEELIATDHAMDILGFSVDEKCACYKIVGALLHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSGDLLKGLLHPRVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTLDTKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQPCIDLIEKPLGILSILEEECMFPKASDASFRAKLYDNHAGKSPNFQQPRPDKKRKYQAHFEVVHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRLLATLYENYAGSCSTEPPKSGVKEKRKKAASFQTVSQLHKENLNKLMTNLRATQPHFVRCIVPNENKTPGVMDAFLVLHQLRCNGVLEGIRICRQGFPNRLLYTDFRQRYRILNPSAIPDDTFMDSRKATEKLLGSLDLDHTQYQFGHTKVFFKAGLLGVLEELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRDALGPKHKE | |||||||
Modified residue (large scale data) | 455 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 1432 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1824 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1825 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver.
Developmental stage
Found in fetal liver and brain.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | A7E2Y1 | SMYD1 Q8NB12 | 2 | EBI-2880253, EBI-8463848 | |
BINARY | A7E2Y1-2 | ETFDH Q16134 | 3 | EBI-12813813, EBI-2870454 | |
BINARY | A7E2Y1-2 | PITX1 P78337 | 3 | EBI-12813813, EBI-748265 | |
BINARY | A7E2Y1-2 | QRICH1 Q2TAL8 | 3 | EBI-12813813, EBI-2798044 | |
BINARY | A7E2Y1-2 | RBPMS Q93062-3 | 3 | EBI-12813813, EBI-740343 | |
BINARY | A7E2Y1-2 | SMYD1 Q8NB12 | 3 | EBI-12813813, EBI-8463848 | |
BINARY | A7E2Y1-2 | TLE5 Q08117-2 | 3 | EBI-12813813, EBI-11741437 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 72-122 | Myosin N-terminal SH3-like | ||||
Sequence: DGKKRVWVPDEQDAYVEAEVKSEATGGRVTVETKDQKVLMVREAELQPMNP | ||||||
Domain | 126-827 | Myosin motor | ||||
Sequence: DLLEDMAMMTHLNEASVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTASVVAAYKGKRRSDSPPHIYAVADNAYNDMLRNRDNQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGKKAQFLATKTGGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPSGKLASADIDSYLLEKSRVIFQLPGERSYHVYYQILSGRKPELQDMLLLSMNPYDYHFCSQGVITVDNMNDGEELIATDHAMDILGFSVDEKCACYKIVGALLHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSGDLLKGLLHPRVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTLDTKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQPCIDLIEKPLGILSILEEECMFPKASDASFRAKLYDNHAGKSPNFQQPRPDKKRKYQAHFEVVHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRLLATLYENYAGSCSTEPPKSGVKEKRKKAASFQTVSQLHKENLNKLMTNLRATQPHFVRCIVPNENKTPGVMDAFLVLHQLRCNGVLEGIRICRQGFPNRLLYTDFRQRYRILNPSAIPDDTFMDSRKATEKLLGSLDLDHTQYQFGHTKVFFKAGLLGVLEELRD | ||||||
Region | 704-726 | Actin-binding | ||||
Sequence: LNKLMTNLRATQPHFVRCIVPNE | ||||||
Region | 806-820 | Actin-binding | ||||
Sequence: QFGHTKVFFKAGLLG | ||||||
Domain | 830-859 | IQ | ||||
Sequence: LAKVLTLLQARSRGRLMRLEYQRLLGGRDA | ||||||
Coiled coil | 888-1977 | |||||
Sequence: LLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRDAL | ||||||
Region | 1946-1983 | Disordered | ||||
Sequence: RKAQHELDDAEERADMAETQANKLRARTRDALGPKHKE |
Sequence similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
A7E2Y1-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,983
- Mass (Da)225,845
- Last updated2018-03-28 v4
- Checksum407E723E41DEB9A8
A7E2Y1-2
- Name2
A7E2Y1-3
- Name3
- Differences from canonical
- 1-1809: Missing
- 1810-1811: DA → MP
A7E2Y1-4
- Name4
- NoteAlternative downstream initiation is supported by sequence conservation.
- Differences from canonical
- 1-42: Missing
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_059497 | 1-42 | in isoform 2 and isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_035359 | 1-1809 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_059498 | 219-1983 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 979 | in Ref. 6; AAH07808 | ||||
Sequence: E → G | ||||||
Alternative sequence | VSP_035361 | 1810-1811 | in isoform 3 | |||
Sequence: DA → MP | ||||||
Sequence conflict | 1900 | in Ref. 1; AAQ93060 | ||||
Sequence: A → V | ||||||
Sequence conflict | 1903 | in Ref. 1; AAQ93060 | ||||
Sequence: A → T | ||||||
Sequence conflict | 1939 | in Ref. 1; AAQ93060 | ||||
Sequence: N → S | ||||||
Sequence conflict | 1973 | in Ref. 1; AAQ93060 | ||||
Sequence: T → S |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY288964 EMBL· GenBank· DDBJ | AAQ93060.1 EMBL· GenBank· DDBJ | mRNA | ||
AB040945 EMBL· GenBank· DDBJ | BAA96036.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK000947 EMBL· GenBank· DDBJ | BAA91440.1 EMBL· GenBank· DDBJ | mRNA | ||
AL133324 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL132825 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF456882 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471077 EMBL· GenBank· DDBJ | EAW76237.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC007808 EMBL· GenBank· DDBJ | AAH07808.1 EMBL· GenBank· DDBJ | mRNA | ||
BC069327 EMBL· GenBank· DDBJ | AAH69327.2 EMBL· GenBank· DDBJ | mRNA | ||
BC069406 EMBL· GenBank· DDBJ | AAH69406.2 EMBL· GenBank· DDBJ | mRNA | ||
BC151242 EMBL· GenBank· DDBJ | AAI51243.1 EMBL· GenBank· DDBJ | mRNA |