A7E237 · A7E237_HUMAN
- ProteinMethylcytosine dioxygenase TET
- GeneTET2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids637 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Publications for A7E237
Uncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination.
- AnnotationUncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination.
- SourceGeneRif: 54790
TET2 Is Downregulated in Early Esophageal Squamous Cell Carcinoma and Promotes Esophageal Squamous Cell Malignant Behaviors.
- AnnotationTET2 Is Downregulated in Early Esophageal Squamous Cell Carcinoma and Promotes Esophageal Squamous Cell Malignant Behaviors.
- SourceGeneRif: 54790
A negative feedback loop between TET2 and leptin in adipocyte regulates body weight.
- AnnotationA negative feedback loop between TET2 and leptin in adipocyte regulates body weight.
- SourceGeneRif: 54790
Association of tet methylcytosine dioxygenase 2 and 5- hydroxymethylcytosine in endometrioid adenocarcinoma and its clinical significance.
- AnnotationAssociation of tet methylcytosine dioxygenase 2 and 5-hydroxymethylcytosine in endometrioid adenocarcinoma and its clinical significance.
- SourceGeneRif: 54790
Identification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation.
- AnnotationIdentification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation.
- SourceGeneRif: 54790
Tet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancer.
- AnnotationTet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancer.
- SourceGeneRif: 54790
TET2 mutation as prototypic clonal hematopoiesis lesion.
- AnnotationTET2 mutation as prototypic clonal hematopoiesis lesion.
- SourceGeneRif: 54790
TET2 mutations contribute to adverse prognosis in acute myeloid leukemia (AML): results from a comprehensive analysis of 502 AML cases and the Beat AML public database.
- AnnotationTET2 mutations contribute to adverse prognosis in acute myeloid leukemia (AML): results from a comprehensive analysis of 502 AML cases and the Beat AML public database.
- SourceGeneRif: 54790
Decreased TET2/5-hmC reduces the integrity of the epidermal barrier via epigenetic dysregulation of filaggrin in psoriatic lesions.
- AnnotationDecreased TET2/5-hmC reduces the integrity of the epidermal barrier via epigenetic dysregulation of filaggrin in psoriatic lesions.
- SourceGeneRif: 54790
Clonal haematopoiesis of indeterminate potential and atrial fibrillation: an east Asian cohort study.
- AnnotationClonal haematopoiesis of indeterminate potential and atrial fibrillation: an east Asian cohort study.
- SourceGeneRif: 54790
TET2-mediated ECM1 hypomethylation promotes the neovascularization in active proliferative diabetic retinopathy.
- AnnotationTET2-mediated ECM1 hypomethylation promotes the neovascularization in active proliferative diabetic retinopathy.
- CategoriesFunction
- SourceGeneRif: 54790
Functional TET2 gene polymorphisms increase the risk of neuroblastoma in Chinese children.
- AnnotationFunctional TET2 gene polymorphisms increase the risk of neuroblastoma in Chinese children.
- SourceGeneRif: 54790
TET2-mediated DNA hydroxymethylation of TGFB1 is related to selective intrauterine growth restriction in monochorionic twin pregnancies.
- AnnotationTET2-mediated DNA hydroxymethylation of TGFB1 is related to selective intrauterine growth restriction in monochorionic twin pregnancies.
- CategoriesFunction
- SourceGeneRif: 54790
Association of Somatic TET2 Mutations With Giant Cell Arteritis.
- AnnotationAssociation of Somatic TET2 Mutations With Giant Cell Arteritis.
- SourceGeneRif: 54790
m6A-Modified circTET2 Interacting with HNRNPC Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia.
- Annotationm6A-Modified circTET2 Interacting with HNRNPC Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia.
- CategoriesFunction
- SourceGeneRif: 54790
DNA dioxygenases TET2 deficiency promotes cigarette smoke induced chronic obstructive pulmonary disease by inducing ferroptosis of lung epithelial cell.
- AnnotationDNA dioxygenases TET2 deficiency promotes cigarette smoke induced chronic obstructive pulmonary disease by inducing ferroptosis of lung epithelial cell.
- SourceGeneRif: 54790
Mutual regulation between GDF11 and TET2 prevents senescence of mesenchymal stem cells.
- AnnotationMutual regulation between GDF11 and TET2 prevents senescence of mesenchymal stem cells.
- CategoriesFunction
- SourceGeneRif: 54790
TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression.
- AnnotationTET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression.
- CategoriesFunction
- SourceGeneRif: 54790
Clonal hematopoiesis with TET2 mutations spawning synchronous primary central nervous system lymphoma and myelodysplastic syndrome.
- AnnotationClonal hematopoiesis with TET2 mutations spawning synchronous primary central nervous system lymphoma and myelodysplastic syndrome.
- CategoriesFunction
- SourceGeneRif: 54790
TET2 inhibits the proliferation and metastasis of lung adenocarcinoma cells via activation of the cGAS-STING signalling pathway.
- AnnotationTET2 inhibits the proliferation and metastasis of lung adenocarcinoma cells via activation of the cGAS-STING signalling pathway.
- CategoriesFunction
- SourceGeneRif: 54790
Nuclear localization of TET2 requires beta-catenin activation and correlates with favourable prognosis in colorectal cancer.
- AnnotationNuclear localization of TET2 requires beta-catenin activation and correlates with favourable prognosis in colorectal cancer.
- SourceGeneRif: 54790
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal.
- AnnotationTET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal.
- CategoriesFunction
- SourceGeneRif: 54790
TOX2 coordinates with TET2 to positively regulate central memory differentiation in human CAR T cells.
- AnnotationTOX2 coordinates with TET2 to positively regulate central memory differentiation in human CAR T cells.
- CategoriesFunction
- SourceGeneRif: 54790
The role of TET2-mediated ROBO4 hypomethylation in the development of diabetic retinopathy.
- AnnotationThe role of TET2-mediated ROBO4 hypomethylation in the development of diabetic retinopathy.
- CategoriesSubcellular Location
- SourceGeneRif: 54790