A7DYK1 · A7DYK1_9PLEU

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      coI
    • Synonyms
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • Hs-1
    • Hs-2
    • Hs-3
    • Hs-4
    • Belik.palt.1
    • Belok.palt.2
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Carangaria > Pleuronectiformes > Pleuronectoidei > Pleuronectidae > Hippoglossus

Accessions

  • Primary accession
    A7DYK1

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane15-37Helical
Transmembrane57-83Helical
Transmembrane104-128Helical
Transmembrane148-171Helical
Transmembrane183-210Helical
Transmembrane243-263Helical
Transmembrane270-291Helical
Transmembrane303-326Helical
Transmembrane338-359Helical
Transmembrane379-400Helical
Transmembrane412-430Helical
Transmembrane450-473Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-511Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    521
  • Mass (Da)
    57,504
  • Last updated
    2007-09-11 v1
  • Checksum
    61087F29625F9ABC
MAITRWFFSTNHKDIGTLYLVFGAWAGMVGTGLSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPTTVTMYQIPLFVWAVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVAYYAGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGSIKWETPLLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIVAAFVHWFPLFTGYTLHSTWTKIHFGLMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTVSSIGSLMSLVAVILFLFIIWEAFTAKREVGAVELTATNIEWLYGCPPPYHTFEEPAFVQVRMNSNKLT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF386396
EMBL· GenBank· DDBJ
AGR51497.1
EMBL· GenBank· DDBJ
Genomic DNA
KF386397
EMBL· GenBank· DDBJ
AGR51498.1
EMBL· GenBank· DDBJ
Genomic DNA
MH032442
EMBL· GenBank· DDBJ
AVR48253.1
EMBL· GenBank· DDBJ
Genomic DNA
MH032443
EMBL· GenBank· DDBJ
AVR48254.1
EMBL· GenBank· DDBJ
Genomic DNA
AM749126
EMBL· GenBank· DDBJ
CAO79671.1
EMBL· GenBank· DDBJ
Genomic DNA
AM749127
EMBL· GenBank· DDBJ
CAO79684.1
EMBL· GenBank· DDBJ
Genomic DNA
AM749128
EMBL· GenBank· DDBJ
CAO79697.1
EMBL· GenBank· DDBJ
Genomic DNA
AM749129
EMBL· GenBank· DDBJ
CAO79710.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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