A7BG22 · A7BG22_9APIC
- ProteinMerozoite surface protein 1
- Genemsp1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1838 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
During the asexual blood stage, involved in merozoite egress from host erythrocytes possibly via its interaction with the host cytoskeleton protein spectrin resulting in the destabilization of the host cytoskeleton and thus leading to erythrocyte cell membrane rupture. Involved in the binding to host erythrocytes and is required for host erythrocyte invasion.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | condensed nuclear chromosome | |
Cellular Component | extracellular region | |
Cellular Component | Mre11 complex | |
Cellular Component | plasma membrane | |
Molecular Function | double-stranded telomeric DNA binding | |
Molecular Function | G-quadruplex DNA binding | |
Molecular Function | hydrolase activity | |
Molecular Function | single-stranded telomeric DNA binding | |
Biological Process | chromosome organization involved in meiotic cell cycle | |
Biological Process | DNA duplex unwinding | |
Biological Process | double-strand break repair | |
Biological Process | telomere maintenance via recombination | |
Biological Process | telomere maintenance via telomerase |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMerozoite surface protein 1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)
Accessions
- Primary accessionA7BG22
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor, GPI-anchor
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1809-1834 | Helical | ||||
Sequence: LFQGVFCSSSSFLSLSFLLLILLFLL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MKALLFLFSFIFFVTKCQC | ||||||
Chain | PRO_5002707458 | 20-1838 | Merozoite surface protein 1 | |||
Sequence: ETEDYKQLLVKLDKLEALVVDGYELFQKKKLEVKDTEVNNNVDANNVNSLAYKIRDFVGKFLELQIPGHSNLLHMIRELVMDNNGLKYLVESYEEFNQLMHVINFHYDLLRAKLNDMCAHEYCKIPEHLKISDKELDMLKKIVLGYRKPLDNIKDDIGKMEAFITKNKETIKKINELIVTENGKRNGHQINNVNSTGAPVDGTQTTRGSTESTQSSGSTGTGSTGTDSTGAVSAATGQAGAVSSSTAGTYPEKKAIFQAIYNIIFYTSQLEEAQKLIEVLEKRVKVLKEHKSIKALLDQVATEKGKLPSTNPPTASLTDVQKEAQTKIADLEKQIVAIAKTVNFDMSGLFTNAEELEYYLREKAKMAGTLITPESTKSAITTEKTVPTMKETYPHGITYALPESTIFELIQKNSSEETFGDLQNPDDGKQPKKGIIISEHKRKELLDKIINKIKLEEDKLPDLKKEYDEKIKAYEKKVEDFQPTLHHFYEGRLENTLDGDKFDQFKTKREEYMKEKKELEKCTYEQNANLINKLKKQLTYLEDYNLRKDVANDEINYFSTMEWKLKNEIYELSKEIRKNESKLTVEKKFDFSGVVELQVQKVLINKKIEALKNVQNLLKNAKVKDDLYIPKVYKTGEKPEPYYLIVLKKEIDKLKDFIPKIETMITTEKAKSGTEAVQIKGQSLRGASETGSSGGTPNAATGVATTQSAVQAQVGTTSAAQSAQQQPVVPAAPGGATTAQGTVPSAATQAAATATTAGGETEAAAGPGPTTGPELATEPAPAPEEPVGPVTPVTTPQPTSQPAAPAAPAAPTMSKLEYLEKLLDFLKSSYACHKHIFVTNSTMNKELLKKYELTDDEKNKIKQSTCDELDLLFNVQNNLPAMYSIYDTMINDLQNLYIELYQKEMLYNIYKNKDTDAKIKAFLETLTSNAAAAAAAPTAAVVPSASAAPAAVAPAEPAENLDEEVVTSPVSTTTAAPGTPESAVTNTQTTPQAEGDQPVGGSSEEEPEVKIEELKNIYEKHLSQIDNYNDYFKKFLESQKENITKMDDTQWKALGVEIEELKKKIQVSLDHYEKYKLKLDRFMKKKNKISNSKEQIKKLTSLKNKLQRRQNLLNNPTSVLKNYTVFFNKKREAEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEESMQKEDNYLNLERFRVLSRIEGRLGNNIDLEKENISYLSSGLHHVFTELKEIINNKRYSGNDHAKNTAAVKVALQAYQELLPKVTTQEGASVPAAGAGAGAAPGVVGTPAAGAGAGPTPGAPEGTGTPGAPAGSTPGAPAGSTPGAPAGSTPGAPEGTGTPGATTATPAAVVPGEAGAAVPGVVGTPAAGAGAGPTPGAPEGTGTPTSTEGSTEIQAQDYAEDYDKVIALPLFGNNDDDGDDKEADQVTMGEAESEAPEIIVPQGINEYDVVYIKPLAGMYKTIKKQLENHVNALNTNIIDMLDSRLKKRNYFLDVLNSDLNPYKYSSSGEYIIKDPYKLLDLEKKKKLLGSYKYIGASVDKDIVTANDGLAYYQKMGDLYKKHLDEVNAQIKEVEANINKHDEEIKKIESEASKANDKNQLNAKKEELQKYLPFLSSIQKEYSTLVNKVHSYTDTLKKIINNCQIEKKETETIVNKLEDYSKMDEELDVYKQSKKEDDVKSSGLLEKLMNSKLINQEESKKALSELLNVQTQMLNMSSEHRCIDTNVPENAACYRYLDGTEEWRCLLYFKEDAGKCVPAPNMTCKDKNGGCAPEAECKMNDKNEIVCKCTKEGSEPLFQGVFCSSSSFLSLSFLLLILLFLLCMEL |
Keywords
- PTM
Expression
Keywords
- Developmental stage
Structure
Family & Domains
Features
Showing features for region, coiled coil, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 204-251 | Disordered | ||||
Sequence: RNGHQINNVNSTGAPVDGTQTTRGSTESTQSSGSTGTGSTGTDSTGAV | ||||||
Coiled coil | 282-309 | |||||
Sequence: IIFYTSQLEEAQKLIEVLEKRVKVLKEH | ||||||
Coiled coil | 333-360 | |||||
Sequence: TASLTDVQKEAQTKIADLEKQIVAIAKT | ||||||
Region | 691-723 | Disordered | ||||
Sequence: SGTEAVQIKGQSLRGASETGSSGGTPNAATGVA | ||||||
Region | 737-828 | Disordered | ||||
Sequence: SAAQSAQQQPVVPAAPGGATTAQGTVPSAATQAAATATTAGGETEAAAGPGPTTGPELATEPAPAPEEPVGPVTPVTTPQPTSQPAAPAAPA | ||||||
Compositional bias | 757-775 | Polar residues | ||||
Sequence: TAQGTVPSAATQAAATATT | ||||||
Compositional bias | 793-824 | Pro residues | ||||
Sequence: ELATEPAPAPEEPVGPVTPVTTPQPTSQPAAP | ||||||
Region | 972-1027 | Disordered | ||||
Sequence: APAEPAENLDEEVVTSPVSTTTAAPGTPESAVTNTQTTPQAEGDQPVGGSSEEEPE | ||||||
Compositional bias | 984-1016 | Polar residues | ||||
Sequence: VVTSPVSTTTAAPGTPESAVTNTQTTPQAEGDQ | ||||||
Domain | 1019-1336 | Merozoite surface 1 C-terminal | ||||
Sequence: GGSSEEEPEVKIEELKNIYEKHLSQIDNYNDYFKKFLESQKENITKMDDTQWKALGVEIEELKKKIQVSLDHYEKYKLKLDRFMKKKNKISNSKEQIKKLTSLKNKLQRRQNLLNNPTSVLKNYTVFFNKKREAEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEESMQKEDNYLNLERFRVLSRIEGRLGNNIDLEKENISYLSSGLHHVFTELKEIINNKRYSGNDHAKNTAAVKVALQAYQELLPKVTTQEGASVPAAGAGAGAAPGVVGTPAAGAGAGPTPGAPEGTGTPGAPAGSTPGAPAGSTPG | ||||||
Coiled coil | 1077-1174 | |||||
Sequence: IEELKKKIQVSLDHYEKYKLKLDRFMKKKNKISNSKEQIKKLTSLKNKLQRRQNLLNNPTSVLKNYTVFFNKKREAEKKEVENTLKNTEILLKYYKAR | ||||||
Region | 1301-1359 | Disordered | ||||
Sequence: AAGAGAGPTPGAPEGTGTPGAPAGSTPGAPAGSTPGAPAGSTPGAPEGTGTPGATTATP | ||||||
Domain | 1353-1663 | Merozoite surface 1 C-terminal | ||||
Sequence: GATTATPAAVVPGEAGAAVPGVVGTPAAGAGAGPTPGAPEGTGTPTSTEGSTEIQAQDYAEDYDKVIALPLFGNNDDDGDDKEADQVTMGEAESEAPEIIVPQGINEYDVVYIKPLAGMYKTIKKQLENHVNALNTNIIDMLDSRLKKRNYFLDVLNSDLNPYKYSSSGEYIIKDPYKLLDLEKKKKLLGSYKYIGASVDKDIVTANDGLAYYQKMGDLYKKHLDEVNAQIKEVEANINKHDEEIKKIESEASKANDKNQLNAKKEELQKYLPFLSSIQKEYSTLVNKVHSYTDTLKKIINNCQIEKKETE | ||||||
Region | 1374-1404 | Disordered | ||||
Sequence: VVGTPAAGAGAGPTPGAPEGTGTPTSTEGST | ||||||
Coiled coil | 1576-1610 | |||||
Sequence: LDEVNAQIKEVEANINKHDEEIKKIESEASKANDK | ||||||
Domain | 1734-1769 | Merozoite surface protein EGF | ||||
Sequence: CIDTNVPENAACYRYLDGTEEWRCLLYFKEDAGKCV |
Sequence similarities
Belongs to the SMC family. RAD50 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,838
- Mass (Da)203,092
- Last updated2007-09-11 v1
- Checksum7575314123334E97
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 757-775 | Polar residues | ||||
Sequence: TAQGTVPSAATQAAATATT | ||||||
Compositional bias | 793-824 | Pro residues | ||||
Sequence: ELATEPAPAPEEPVGPVTPVTTPQPTSQPAAP | ||||||
Compositional bias | 984-1016 | Polar residues | ||||
Sequence: VVTSPVSTTTAAPGTPESAVTNTQTTPQAEGDQ |