A7BG22 · A7BG22_9APIC

  • Protein
    Merozoite surface protein 1
  • Gene
    msp1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

During the asexual blood stage, involved in merozoite egress from host erythrocytes possibly via its interaction with the host cytoskeleton protein spectrin resulting in the destabilization of the host cytoskeleton and thus leading to erythrocyte cell membrane rupture. Involved in the binding to host erythrocytes and is required for host erythrocyte invasion.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcondensed nuclear chromosome
Cellular Componentextracellular region
Cellular ComponentMre11 complex
Cellular Componentplasma membrane
Molecular Functiondouble-stranded telomeric DNA binding
Molecular FunctionG-quadruplex DNA binding
Molecular Functionhydrolase activity
Molecular Functionsingle-stranded telomeric DNA binding
Biological Processchromosome organization involved in meiotic cell cycle
Biological ProcessDNA duplex unwinding
Biological Processdouble-strand break repair
Biological Processtelomere maintenance via recombination
Biological Processtelomere maintenance via telomerase

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Merozoite surface protein 1
  • Alternative names
    • Merozoite surface antigen
    • PMMSA

Gene names

    • Name
      msp1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • T824
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)

Accessions

  • Primary accession
    A7BG22

Organism-specific databases

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor
Secreted

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1809-1834Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_500270745820-1838Merozoite surface protein 1

Keywords

Expression

Keywords

  • Developmental stage

Family & Domains

Features

Showing features for region, coiled coil, compositional bias, domain.

TypeIDPosition(s)Description
Region204-251Disordered
Coiled coil282-309
Coiled coil333-360
Region691-723Disordered
Region737-828Disordered
Compositional bias757-775Polar residues
Compositional bias793-824Pro residues
Region972-1027Disordered
Compositional bias984-1016Polar residues
Domain1019-1336Merozoite surface 1 C-terminal
Coiled coil1077-1174
Region1301-1359Disordered
Domain1353-1663Merozoite surface 1 C-terminal
Region1374-1404Disordered
Coiled coil1576-1610
Domain1734-1769Merozoite surface protein EGF

Sequence similarities

Belongs to the SMC family. RAD50 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,838
  • Mass (Da)
    203,092
  • Last updated
    2007-09-11 v1
  • Checksum
    7575314123334E97
MKALLFLFSFIFFVTKCQCETEDYKQLLVKLDKLEALVVDGYELFQKKKLEVKDTEVNNNVDANNVNSLAYKIRDFVGKFLELQIPGHSNLLHMIRELVMDNNGLKYLVESYEEFNQLMHVINFHYDLLRAKLNDMCAHEYCKIPEHLKISDKELDMLKKIVLGYRKPLDNIKDDIGKMEAFITKNKETIKKINELIVTENGKRNGHQINNVNSTGAPVDGTQTTRGSTESTQSSGSTGTGSTGTDSTGAVSAATGQAGAVSSSTAGTYPEKKAIFQAIYNIIFYTSQLEEAQKLIEVLEKRVKVLKEHKSIKALLDQVATEKGKLPSTNPPTASLTDVQKEAQTKIADLEKQIVAIAKTVNFDMSGLFTNAEELEYYLREKAKMAGTLITPESTKSAITTEKTVPTMKETYPHGITYALPESTIFELIQKNSSEETFGDLQNPDDGKQPKKGIIISEHKRKELLDKIINKIKLEEDKLPDLKKEYDEKIKAYEKKVEDFQPTLHHFYEGRLENTLDGDKFDQFKTKREEYMKEKKELEKCTYEQNANLINKLKKQLTYLEDYNLRKDVANDEINYFSTMEWKLKNEIYELSKEIRKNESKLTVEKKFDFSGVVELQVQKVLINKKIEALKNVQNLLKNAKVKDDLYIPKVYKTGEKPEPYYLIVLKKEIDKLKDFIPKIETMITTEKAKSGTEAVQIKGQSLRGASETGSSGGTPNAATGVATTQSAVQAQVGTTSAAQSAQQQPVVPAAPGGATTAQGTVPSAATQAAATATTAGGETEAAAGPGPTTGPELATEPAPAPEEPVGPVTPVTTPQPTSQPAAPAAPAAPTMSKLEYLEKLLDFLKSSYACHKHIFVTNSTMNKELLKKYELTDDEKNKIKQSTCDELDLLFNVQNNLPAMYSIYDTMINDLQNLYIELYQKEMLYNIYKNKDTDAKIKAFLETLTSNAAAAAAAPTAAVVPSASAAPAAVAPAEPAENLDEEVVTSPVSTTTAAPGTPESAVTNTQTTPQAEGDQPVGGSSEEEPEVKIEELKNIYEKHLSQIDNYNDYFKKFLESQKENITKMDDTQWKALGVEIEELKKKIQVSLDHYEKYKLKLDRFMKKKNKISNSKEQIKKLTSLKNKLQRRQNLLNNPTSVLKNYTVFFNKKREAEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEESMQKEDNYLNLERFRVLSRIEGRLGNNIDLEKENISYLSSGLHHVFTELKEIINNKRYSGNDHAKNTAAVKVALQAYQELLPKVTTQEGASVPAAGAGAGAAPGVVGTPAAGAGAGPTPGAPEGTGTPGAPAGSTPGAPAGSTPGAPAGSTPGAPEGTGTPGATTATPAAVVPGEAGAAVPGVVGTPAAGAGAGPTPGAPEGTGTPTSTEGSTEIQAQDYAEDYDKVIALPLFGNNDDDGDDKEADQVTMGEAESEAPEIIVPQGINEYDVVYIKPLAGMYKTIKKQLENHVNALNTNIIDMLDSRLKKRNYFLDVLNSDLNPYKYSSSGEYIIKDPYKLLDLEKKKKLLGSYKYIGASVDKDIVTANDGLAYYQKMGDLYKKHLDEVNAQIKEVEANINKHDEEIKKIESEASKANDKNQLNAKKEELQKYLPFLSSIQKEYSTLVNKVHSYTDTLKKIINNCQIEKKETETIVNKLEDYSKMDEELDVYKQSKKEDDVKSSGLLEKLMNSKLINQEESKKALSELLNVQTQMLNMSSEHRCIDTNVPENAACYRYLDGTEEWRCLLYFKEDAGKCVPAPNMTCKDKNGGCAPEAECKMNDKNEIVCKCTKEGSEPLFQGVFCSSSSFLSLSFLLLILLFLLCMEL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias757-775Polar residues
Compositional bias793-824Pro residues
Compositional bias984-1016Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB266187
EMBL· GenBank· DDBJ
BAF74055.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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