A7AW49 · ASNA_BABBO
- ProteinATPase ASNA1 homolog
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids358 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 35-42 | ATP (UniProtKB | ChEBI) | |||
Active site | 64 | ||||
Binding site | 235 | ATP (UniProtKB | ChEBI) | |||
Binding site | 262 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | GET complex | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Biological Process | post-translational protein targeting to endoplasmic reticulum membrane | |
Biological Process | protein insertion into ER membrane |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATPase ASNA1 homolog
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Piroplasmida > Babesiidae > Babesia
Accessions
- Primary accessionA7AW49
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000388165 | 1-358 | ATPase ASNA1 homolog | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length358
- Mass (Da)40,565
- Last updated2007-09-11 v1
- Checksum41C27297048EB8AB
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAXT02000002 EMBL· GenBank· DDBJ | EDO05277.1 EMBL· GenBank· DDBJ | Genomic DNA |