A7AW49 · ASNA_BABBO

  • Protein
    ATPase ASNA1 homolog
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

Features

Showing features for binding site, active site.

135850100150200250300350
Type
IDPosition(s)Description
Binding site35-42ATP (UniProtKB | ChEBI)
Active site64
Binding site235ATP (UniProtKB | ChEBI)
Binding site262ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentGET complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Biological Processpost-translational protein targeting to endoplasmic reticulum membrane
Biological Processprotein insertion into ER membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATPase ASNA1 homolog
  • EC number
  • Alternative names
    • Arsenical pump-driving ATPase homolog
    • Arsenite-stimulated ATPase

Gene names

    • ORF names
      BBOV_I001930

Organism names

  • Taxonomic identifier
  • Strain
    • T2Bo
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Piroplasmida > Babesiidae > Babesia

Accessions

  • Primary accession
    A7AW49

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003881651-358ATPase ASNA1 homolog

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the arsA ATPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    358
  • Mass (Da)
    40,565
  • Last updated
    2007-09-11 v1
  • Checksum
    41C27297048EB8AB
MVEITEVIEPEWQTRNDIQNLVNQKTLQWVFVGGKGGVGKTTISSSIATALAETRESVLLLSTDPAHSLSDAFGQKFTHEPRLVNGFTNLYAMELNTSQIIDGLDGLRETHSFLKNVPDILMMLPGIDEALSFVELMQSVQSRRFSVTIFDTAPTGHTLKFLKLPDVLEKILDSLLKLENTMGGLLQLFSSMTKAQMSQNELFDKIKLLGDMINTTHEQMKNPDLTTFICVCIPEFLSVYETERLIQDLAKSEIDCSYIIVNQVLKHIQLGGLIEDAWDGLTEEQQRIMTPFFEKVREHHSTHNSRVDVQRKYLSDIKDLYQEDFNIVAVHQNKQEVRGKDALVAFAKKLMQHSPLPI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAXT02000002
EMBL· GenBank· DDBJ
EDO05277.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp