A7ARA6 · A7ARA6_BABBO
- ProteinDihydrolipoyl dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids481 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Miscellaneous
The active site is a redox-active disulfide bond.
Catalytic activity
- N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD+ = N6-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H+
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 71 | FAD (UniProtKB | ChEBI) | |||
Binding site | 133 | FAD (UniProtKB | ChEBI) | |||
Binding site | 158-160 | FAD (UniProtKB | ChEBI) | |||
Binding site | 197-204 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 220 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 287 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 328 | FAD (UniProtKB | ChEBI) | |||
Binding site | 334-337 | FAD (UniProtKB | ChEBI) | |||
Active site | 460 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | oxoglutarate dehydrogenase complex | |
Molecular Function | dihydrolipoyl dehydrogenase activity | |
Molecular Function | flavin adenine dinucleotide binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydrolipoyl dehydrogenase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Piroplasmida > Babesiidae > Babesia
Accessions
- Primary accessionA7ARA6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 62↔67 | Redox-active | |||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 24-343 | FAD/NAD(P)-binding | |||
Domain | 363-470 | Pyridine nucleotide-disulphide oxidoreductase dimerisation | |||
Sequence similarities
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length481
- Mass (Da)51,467
- Last updated2007-09-11 v1
- Checksum2F7D05FB6C1537E8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAXT01000002 EMBL· GenBank· DDBJ | EDO07075.1 EMBL· GenBank· DDBJ | Genomic DNA |