A7A2A4 · A7A2A4_YEAS7

Function

function

Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.
Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionRNA binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological ProcessDNA integration
Biological Processtransposition

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Integrase catalytic domain-containing protein

Gene names

    • ORF names
      SCY_4025

Organism names

Accessions

  • Primary accession
    A7A2A4

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain60-235Integrase catalytic
Region356-604Disordered
Compositional bias369-383Basic and acidic residues
Compositional bias393-417Polar residues
Compositional bias439-456Basic and acidic residues
Compositional bias457-480Polar residues
Compositional bias494-511Polar residues
Compositional bias549-578Polar residues
Compositional bias579-595Basic and acidic residues

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    604
  • Mass (Da)
    67,775
  • Last updated
    2007-09-11 v1
  • Checksum
    5FE487318DDCD59D
MLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYQSFIASNEIQQSNDLNIESDHDFQSDIELYPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISDIESTGSGGMHKLNVPLLAPMSQSETHESSHASKSKDFRHSDSYSDNETNHTNAPISSTGGTNNKTVPQTSEQETEKRIIHRSPSIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTELSDSFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSL

Features

Showing features for compositional bias, non-terminal residue.

TypeIDPosition(s)Description
Compositional bias369-383Basic and acidic residues
Compositional bias393-417Polar residues
Compositional bias439-456Basic and acidic residues
Compositional bias457-480Polar residues
Compositional bias494-511Polar residues
Compositional bias549-578Polar residues
Compositional bias579-595Basic and acidic residues
Non-terminal residue604

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAFW02000192
EMBL· GenBank· DDBJ
EDN59088.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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