A7A1I0 · A7A1I0_YEAS7

Function

function

Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Sulfur metabolism; glutathione metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site177L-glutamate (UniProtKB | ChEBI)
Active site470Nucleophile
Binding site488-490L-glutamate (UniProtKB | ChEBI)
Binding site512L-glutamate (UniProtKB | ChEBI)
Binding site540-541L-glutamate (UniProtKB | ChEBI)
Binding site563L-glutamate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentfungal-type vacuole
Cellular Componentplasma membrane
Molecular Functionglutathione hydrolase activity
Molecular Functionleukotriene C4 gamma-glutamyl transferase activity
Biological Processglutathione catabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione hydrolase
  • EC number
  • Alternative names
    • Gamma-glutamyltransferase
    • Gamma-glutamyltranspeptidase

Gene names

    • Name
      ECM38
    • ORF names
      SCY_3858

Organism names

Accessions

  • Primary accession
    A7A1I0

Proteomes

Subcellular Location

Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-33Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias73-88Basic and acidic residues
Region73-92Disordered

Sequence similarities

Belongs to the gamma-glutamyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    660
  • Mass (Da)
    73,180
  • Last updated
    2007-09-11 v1
  • Checksum
    9896E9EBFF822F55
MLLCNRKVPKTLNTCFILHIFTLLTLGVLVSGMPSKMVSFASQETLQRINNLLRGSANRDVDIIAEYLKKDDDDDGGDKDHHNIDIDPLPRRPSLTPDRQLLKVGLHGAISSDLEVCSNLTINEVLLKFPGSNAADAAVTQALCKGMVNFFNSGIGGGGYVVFSGKDDEDHLSIDFREKAPMDSHKFMFENCSLCSKIGGLAVGVPGELMGLYRLFKERGSGQVDWRDLIEPVAKLGSVGWQIGEALGATLELYEDVFLTLKEDWSFVLNSTHDGVLKEGDWIKRPALSNMLMELAKNGSVAPFYDPDHWIAKSMIDTVAKYNGIMNLQDVSSYDVHVTKPLSMKIRKGANFIPDNDMTVLTSSGSSSGAALLAALRIMDNFQNQEGGDYEKETTYHLLESMKWMASARSRLGDFEGEALPKHIEEVLDPEWALKAVKSIKRNSQDGNFKTLENWTLYDPAYDINNPHGTAHFSIVDSHGNAVSLTTTINLLFGSLVHDPKTGVIFNNEMDDFAQFNKSNSFELAPSIYNFPEPGKRPLSSTAPTIVLSELGIPDLVVGASGGSRITTSVLQTIVRTYWYNMPILETIAYPRIHHQLLPDRIELESFPMIGKAVLSTLKEMGYTMKEVFPKSVVNAIRNVRGEWHAVSDYWRKRGISSVY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias73-88Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAFW02000170
EMBL· GenBank· DDBJ
EDN59384.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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