A7A1I0 · A7A1I0_YEAS7
- ProteinGlutathione hydrolase
- GeneECM38
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids660 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Catalytic activity
- an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
Pathway
Sulfur metabolism; glutathione metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 177 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Active site | 470 | Nucleophile | ||||
Sequence: T | ||||||
Binding site | 488-490 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: TIN | ||||||
Binding site | 512 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 540-541 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: SS | ||||||
Binding site | 563 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | fungal-type vacuole | |
Cellular Component | plasma membrane | |
Molecular Function | glutathione hydrolase activity | |
Molecular Function | leukotriene C4 gamma-glutamyl transferase activity | |
Biological Process | glutathione catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione hydrolase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionA7A1I0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-33 | Helical | ||||
Sequence: LNTCFILHIFTLLTLGVLVSGM |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 73-88 | Basic and acidic residues | ||||
Sequence: DDDGGDKDHHNIDIDP | ||||||
Region | 73-92 | Disordered | ||||
Sequence: DDDGGDKDHHNIDIDPLPRR |
Sequence similarities
Belongs to the gamma-glutamyltransferase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length660
- Mass (Da)73,180
- Last updated2007-09-11 v1
- Checksum9896E9EBFF822F55
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 73-88 | Basic and acidic residues | ||||
Sequence: DDDGGDKDHHNIDIDP |