A6YZ48 · A6YZ48_HUMAN

  • Protein
    NADH-ubiquinone oxidoreductase chain 5
  • Gene
    ND5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 5
  • EC number

Gene names

    • Name
      ND5
    • Synonyms
      MTND5

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • FTDNA B624363
    • FTDNA MI60151
    • Poz416
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A6YZ48

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane84-105Helical
Transmembrane117-134Helical
Transmembrane140-160Helical
Transmembrane172-191Helical
Transmembrane211-233Helical
Transmembrane245-266Helical
Transmembrane272-294Helical
Transmembrane301-319Helical
Transmembrane325-347Helical
Transmembrane368-386Helical
Transmembrane406-433Helical
Transmembrane454-472Helical
Transmembrane484-507Helical
Transmembrane584-602Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_501351879222-603NADH-ubiquinone oxidoreductase chain 5

Proteomic databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain68-118NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Domain134-419NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain422-602NADH dehydrogenase subunit 5 C-terminal

Sequence similarities

Belongs to the complex I subunit 5 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    603
  • Mass (Da)
    67,057
  • Last updated
    2007-08-21 v1
  • Checksum
    18A0623EB2C90F33
MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLMSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF657385
EMBL· GenBank· DDBJ
ABR94978.1
EMBL· GenBank· DDBJ
Genomic DNA
EF657513
EMBL· GenBank· DDBJ
ABR96640.1
EMBL· GenBank· DDBJ
Genomic DNA
EF657521
EMBL· GenBank· DDBJ
ABR96744.1
EMBL· GenBank· DDBJ
Genomic DNA
EU239477
EMBL· GenBank· DDBJ
ABW76521.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383610
EMBL· GenBank· DDBJ
ACM75066.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383612
EMBL· GenBank· DDBJ
ACM75092.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383614
EMBL· GenBank· DDBJ
ACM75118.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383615
EMBL· GenBank· DDBJ
ACM75131.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383647
EMBL· GenBank· DDBJ
ACM75547.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383649
EMBL· GenBank· DDBJ
ACM75573.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383766
EMBL· GenBank· DDBJ
ACM77094.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ951548
EMBL· GenBank· DDBJ
ACQ75345.1
EMBL· GenBank· DDBJ
Genomic DNA
GU361772
EMBL· GenBank· DDBJ
ADB07258.1
EMBL· GenBank· DDBJ
Genomic DNA
GU722600
EMBL· GenBank· DDBJ
ADC79091.1
EMBL· GenBank· DDBJ
Genomic DNA
GU797785
EMBL· GenBank· DDBJ
ADC79267.1
EMBL· GenBank· DDBJ
Genomic DNA
HM765456
EMBL· GenBank· DDBJ
ADK66474.1
EMBL· GenBank· DDBJ
Genomic DNA
HM036530
EMBL· GenBank· DDBJ
ADK72659.1
EMBL· GenBank· DDBJ
Genomic DNA
HM036538
EMBL· GenBank· DDBJ
ADK72763.1
EMBL· GenBank· DDBJ
Genomic DNA
HM036541
EMBL· GenBank· DDBJ
ADK72802.1
EMBL· GenBank· DDBJ
Genomic DNA
HM036554
EMBL· GenBank· DDBJ
ADK72971.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824834
EMBL· GenBank· DDBJ
AEG62400.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824927
EMBL· GenBank· DDBJ
AEG63609.1
EMBL· GenBank· DDBJ
Genomic DNA
JN655842
EMBL· GenBank· DDBJ
AEQ27293.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ701895
EMBL· GenBank· DDBJ
AFF62603.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702168
EMBL· GenBank· DDBJ
AFF66152.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702304
EMBL· GenBank· DDBJ
AFF67920.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702745
EMBL· GenBank· DDBJ
AFF73653.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702752
EMBL· GenBank· DDBJ
AFF73744.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702919
EMBL· GenBank· DDBJ
AFF75915.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ703008
EMBL· GenBank· DDBJ
AFF77072.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ703130
EMBL· GenBank· DDBJ
AFF78658.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705225
EMBL· GenBank· DDBJ
AFG05893.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705400
EMBL· GenBank· DDBJ
AFG08168.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705685
EMBL· GenBank· DDBJ
AFG11873.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705686
EMBL· GenBank· DDBJ
AFG11886.1
EMBL· GenBank· DDBJ
Genomic DNA
JX091694
EMBL· GenBank· DDBJ
AFK31705.1
EMBL· GenBank· DDBJ
Genomic DNA
JX152882
EMBL· GenBank· DDBJ
AFO21649.1
EMBL· GenBank· DDBJ
Genomic DNA
JX152901
EMBL· GenBank· DDBJ
AFO21896.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153209
EMBL· GenBank· DDBJ
AFO25900.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153356
EMBL· GenBank· DDBJ
AFO27811.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153378
EMBL· GenBank· DDBJ
AFO28097.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153429
EMBL· GenBank· DDBJ
AFO28760.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153706
EMBL· GenBank· DDBJ
AFO32361.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153865
EMBL· GenBank· DDBJ
AFO34428.1
EMBL· GenBank· DDBJ
Genomic DNA
JX154012
EMBL· GenBank· DDBJ
AFO36339.1
EMBL· GenBank· DDBJ
Genomic DNA
JX891380
EMBL· GenBank· DDBJ
AFU76052.1
EMBL· GenBank· DDBJ
Genomic DNA
KC158584
EMBL· GenBank· DDBJ
AFY07373.1
EMBL· GenBank· DDBJ
Genomic DNA
KC250336
EMBL· GenBank· DDBJ
AFZ81782.1
EMBL· GenBank· DDBJ
Genomic DNA
KF048032
EMBL· GenBank· DDBJ
AGL96428.1
EMBL· GenBank· DDBJ
Genomic DNA
KF161067
EMBL· GenBank· DDBJ
AGW54447.1
EMBL· GenBank· DDBJ
Genomic DNA
KF161232
EMBL· GenBank· DDBJ
AGW56592.1
EMBL· GenBank· DDBJ
Genomic DNA
KF162474
EMBL· GenBank· DDBJ
AGW72737.1
EMBL· GenBank· DDBJ
Genomic DNA
KF162683
EMBL· GenBank· DDBJ
AGW75454.1
EMBL· GenBank· DDBJ
Genomic DNA
KF162711
EMBL· GenBank· DDBJ
AGW75818.1
EMBL· GenBank· DDBJ
Genomic DNA
KF849938
EMBL· GenBank· DDBJ
AHE79092.1
EMBL· GenBank· DDBJ
Genomic DNA
KU171094
EMBL· GenBank· DDBJ
AMW67588.1
EMBL· GenBank· DDBJ
Genomic DNA
KU171095
EMBL· GenBank· DDBJ
AMW67601.1
EMBL· GenBank· DDBJ
Genomic DNA
KT587372
EMBL· GenBank· DDBJ
AMZ80639.1
EMBL· GenBank· DDBJ
Genomic DNA
KT587454
EMBL· GenBank· DDBJ
AMZ81705.1
EMBL· GenBank· DDBJ
Genomic DNA
KX530932
EMBL· GenBank· DDBJ
ANT45939.1
EMBL· GenBank· DDBJ
Genomic DNA
KY399162
EMBL· GenBank· DDBJ
AQU13333.1
EMBL· GenBank· DDBJ
Genomic DNA
KY595587
EMBL· GenBank· DDBJ
ARD72265.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645558
EMBL· GenBank· DDBJ
ASR13041.1
EMBL· GenBank· DDBJ
Genomic DNA
MF522951
EMBL· GenBank· DDBJ
ATL18476.1
EMBL· GenBank· DDBJ
Genomic DNA
MF523013
EMBL· GenBank· DDBJ
ATL19282.1
EMBL· GenBank· DDBJ
Genomic DNA
MF523027
EMBL· GenBank· DDBJ
ATL19464.1
EMBL· GenBank· DDBJ
Genomic DNA
MF523058
EMBL· GenBank· DDBJ
ATL19867.1
EMBL· GenBank· DDBJ
Genomic DNA
MF523173
EMBL· GenBank· DDBJ
ATL21362.1
EMBL· GenBank· DDBJ
Genomic DNA
MF114221
EMBL· GenBank· DDBJ
ATV99009.1
EMBL· GenBank· DDBJ
Genomic DNA
MG571160
EMBL· GenBank· DDBJ
AUG60160.1
EMBL· GenBank· DDBJ
Genomic DNA
MG571187
EMBL· GenBank· DDBJ
AUG60511.1
EMBL· GenBank· DDBJ
Genomic DNA
MG272710
EMBL· GenBank· DDBJ
AVL86660.1
EMBL· GenBank· DDBJ
Genomic DNA
MH448993
EMBL· GenBank· DDBJ
AYW04631.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449008
EMBL· GenBank· DDBJ
AYW04826.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449012
EMBL· GenBank· DDBJ
AYW04878.1
EMBL· GenBank· DDBJ
Genomic DNA
MH120537
EMBL· GenBank· DDBJ
AZJ09593.1
EMBL· GenBank· DDBJ
Genomic DNA
MK128858
EMBL· GenBank· DDBJ
QBB88052.1
EMBL· GenBank· DDBJ
Genomic DNA
MK059650
EMBL· GenBank· DDBJ
QCB18668.1
EMBL· GenBank· DDBJ
Genomic DNA
MN150712
EMBL· GenBank· DDBJ
QDR51127.1
EMBL· GenBank· DDBJ
Genomic DNA
MK860674
EMBL· GenBank· DDBJ
QEG54762.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849777
EMBL· GenBank· DDBJ
QKT25645.1
EMBL· GenBank· DDBJ
Genomic DNA
MN687135
EMBL· GenBank· DDBJ
QLH90593.1
EMBL· GenBank· DDBJ
Genomic DNA
MN687288
EMBL· GenBank· DDBJ
QLH92582.1
EMBL· GenBank· DDBJ
Genomic DNA
MW010366
EMBL· GenBank· DDBJ
QOE88590.1
EMBL· GenBank· DDBJ
Genomic DNA
MW010367
EMBL· GenBank· DDBJ
QOE88603.1
EMBL· GenBank· DDBJ
Genomic DNA
MT588243
EMBL· GenBank· DDBJ
QQD78595.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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