A6YZ48 · A6YZ48_HUMAN
- ProteinNADH-ubiquinone oxidoreductase chain 5
- GeneND5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids603 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 5
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA6YZ48
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 84-105 | Helical | ||||
Sequence: YFSMMFIPVALFVTWSIMEFSL | ||||||
Transmembrane | 117-134 | Helical | ||||
Sequence: FFKYLLIFLITMLILVTA | ||||||
Transmembrane | 140-160 | Helical | ||||
Sequence: LFIGWEGVGIMSFLLISWWYA | ||||||
Transmembrane | 172-191 | Helical | ||||
Sequence: ILYNRIGDIGFILALAWFIL | ||||||
Transmembrane | 211-233 | Helical | ||||
Sequence: TPLLGLLLAAAGKSAQLGLHPWL | ||||||
Transmembrane | 245-266 | Helical | ||||
Sequence: ALLHSSTMVVAGIFLLIRFHPL | ||||||
Transmembrane | 272-294 | Helical | ||||
Sequence: LIQTLTLCLGAITTLFAAVCALT | ||||||
Transmembrane | 301-319 | Helical | ||||
Sequence: IVAFSTSSQLGLMMVTIGI | ||||||
Transmembrane | 325-347 | Helical | ||||
Sequence: AFLHICTHAFFKAMLFMCSGSII | ||||||
Transmembrane | 368-386 | Helical | ||||
Sequence: LTSTSLTIGSLALAGMPFL | ||||||
Transmembrane | 406-433 | Helical | ||||
Sequence: AWALSITLIATSLTSAYSTRMILLTLTG | ||||||
Transmembrane | 454-472 | Helical | ||||
Sequence: IKRLAAGSLFAGFLITNNI | ||||||
Transmembrane | 484-507 | Helical | ||||
Sequence: LYLKLTALAVTFLGLLTALDLNYL | ||||||
Transmembrane | 584-602 | Helical | ||||
Sequence: IKLYFLSFFFPLILTLLLI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MTMHTTMTTLTLTSLIPPILT | ||||||
Chain | PRO_5013518792 | 22-603 | NADH-ubiquinone oxidoreductase chain 5 | |||
Sequence: TLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLMSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT |
Proteomic databases
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 68-118 | NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal | ||||
Sequence: WATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFF | ||||||
Domain | 134-419 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: ANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLT | ||||||
Domain | 422-602 | NADH dehydrogenase subunit 5 C-terminal | ||||
Sequence: YSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLMSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLI |
Sequence similarities
Belongs to the complex I subunit 5 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length603
- Mass (Da)67,057
- Last updated2007-08-21 v1
- Checksum18A0623EB2C90F33
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EF657385 EMBL· GenBank· DDBJ | ABR94978.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657513 EMBL· GenBank· DDBJ | ABR96640.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657521 EMBL· GenBank· DDBJ | ABR96744.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU239477 EMBL· GenBank· DDBJ | ABW76521.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383610 EMBL· GenBank· DDBJ | ACM75066.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383612 EMBL· GenBank· DDBJ | ACM75092.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383614 EMBL· GenBank· DDBJ | ACM75118.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383615 EMBL· GenBank· DDBJ | ACM75131.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383647 EMBL· GenBank· DDBJ | ACM75547.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383649 EMBL· GenBank· DDBJ | ACM75573.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383766 EMBL· GenBank· DDBJ | ACM77094.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ951548 EMBL· GenBank· DDBJ | ACQ75345.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU361772 EMBL· GenBank· DDBJ | ADB07258.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU722600 EMBL· GenBank· DDBJ | ADC79091.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU797785 EMBL· GenBank· DDBJ | ADC79267.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM765456 EMBL· GenBank· DDBJ | ADK66474.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM036530 EMBL· GenBank· DDBJ | ADK72659.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM036538 EMBL· GenBank· DDBJ | ADK72763.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM036541 EMBL· GenBank· DDBJ | ADK72802.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM036554 EMBL· GenBank· DDBJ | ADK72971.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF824834 EMBL· GenBank· DDBJ | AEG62400.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF824927 EMBL· GenBank· DDBJ | AEG63609.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN655842 EMBL· GenBank· DDBJ | AEQ27293.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ701895 EMBL· GenBank· DDBJ | AFF62603.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702168 EMBL· GenBank· DDBJ | AFF66152.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702304 EMBL· GenBank· DDBJ | AFF67920.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702745 EMBL· GenBank· DDBJ | AFF73653.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702752 EMBL· GenBank· DDBJ | AFF73744.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702919 EMBL· GenBank· DDBJ | AFF75915.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ703008 EMBL· GenBank· DDBJ | AFF77072.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ703130 EMBL· GenBank· DDBJ | AFF78658.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705225 EMBL· GenBank· DDBJ | AFG05893.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705400 EMBL· GenBank· DDBJ | AFG08168.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705685 EMBL· GenBank· DDBJ | AFG11873.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705686 EMBL· GenBank· DDBJ | AFG11886.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX091694 EMBL· GenBank· DDBJ | AFK31705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX152882 EMBL· GenBank· DDBJ | AFO21649.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX152901 EMBL· GenBank· DDBJ | AFO21896.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153209 EMBL· GenBank· DDBJ | AFO25900.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153356 EMBL· GenBank· DDBJ | AFO27811.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153378 EMBL· GenBank· DDBJ | AFO28097.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153429 EMBL· GenBank· DDBJ | AFO28760.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153706 EMBL· GenBank· DDBJ | AFO32361.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153865 EMBL· GenBank· DDBJ | AFO34428.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX154012 EMBL· GenBank· DDBJ | AFO36339.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX891380 EMBL· GenBank· DDBJ | AFU76052.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC158584 EMBL· GenBank· DDBJ | AFY07373.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC250336 EMBL· GenBank· DDBJ | AFZ81782.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF048032 EMBL· GenBank· DDBJ | AGL96428.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF161067 EMBL· GenBank· DDBJ | AGW54447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF161232 EMBL· GenBank· DDBJ | AGW56592.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF162474 EMBL· GenBank· DDBJ | AGW72737.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF162683 EMBL· GenBank· DDBJ | AGW75454.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF162711 EMBL· GenBank· DDBJ | AGW75818.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF849938 EMBL· GenBank· DDBJ | AHE79092.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU171094 EMBL· GenBank· DDBJ | AMW67588.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU171095 EMBL· GenBank· DDBJ | AMW67601.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT587372 EMBL· GenBank· DDBJ | AMZ80639.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT587454 EMBL· GenBank· DDBJ | AMZ81705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX530932 EMBL· GenBank· DDBJ | ANT45939.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY399162 EMBL· GenBank· DDBJ | AQU13333.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY595587 EMBL· GenBank· DDBJ | ARD72265.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645558 EMBL· GenBank· DDBJ | ASR13041.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF522951 EMBL· GenBank· DDBJ | ATL18476.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF523013 EMBL· GenBank· DDBJ | ATL19282.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF523027 EMBL· GenBank· DDBJ | ATL19464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF523058 EMBL· GenBank· DDBJ | ATL19867.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF523173 EMBL· GenBank· DDBJ | ATL21362.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF114221 EMBL· GenBank· DDBJ | ATV99009.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG571160 EMBL· GenBank· DDBJ | AUG60160.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG571187 EMBL· GenBank· DDBJ | AUG60511.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272710 EMBL· GenBank· DDBJ | AVL86660.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH448993 EMBL· GenBank· DDBJ | AYW04631.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449008 EMBL· GenBank· DDBJ | AYW04826.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449012 EMBL· GenBank· DDBJ | AYW04878.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH120537 EMBL· GenBank· DDBJ | AZJ09593.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK128858 EMBL· GenBank· DDBJ | QBB88052.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK059650 EMBL· GenBank· DDBJ | QCB18668.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN150712 EMBL· GenBank· DDBJ | QDR51127.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK860674 EMBL· GenBank· DDBJ | QEG54762.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN849777 EMBL· GenBank· DDBJ | QKT25645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN687135 EMBL· GenBank· DDBJ | QLH90593.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN687288 EMBL· GenBank· DDBJ | QLH92582.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW010366 EMBL· GenBank· DDBJ | QOE88590.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW010367 EMBL· GenBank· DDBJ | QOE88603.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT588243 EMBL· GenBank· DDBJ | QQD78595.1 EMBL· GenBank· DDBJ | Genomic DNA |