A6YWL9 · A6YWL9_HUMAN
- ProteinNADH-ubiquinone oxidoreductase chain 1
- GeneND1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids318 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- a ubiquinone + NADH + 5 H+(in) = a ubiquinol + NAD+ + 4 H+(out)
a ubiquinone RHEA-COMP:9565 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= a ubiquinol RHEA-COMP:9566 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA6YWL9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 6-23 | Helical | |||
Transmembrane | 68-86 | Helical | |||
Transmembrane | 98-119 | Helical | |||
Transmembrane | 140-160 | Helical | |||
Transmembrane | 172-191 | Helical | |||
Transmembrane | 220-243 | Helical | |||
Transmembrane | 255-273 | Helical | |||
Transmembrane | 293-314 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Sequence
- Sequence statusComplete
- Length318
- Mass (Da)35,723
- Last updated2007-08-21 v1
- MD5 ChecksumACB8958DEC032F170F7C7C9ADB385AFA
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EF429139 EMBL· GenBank· DDBJ | ABN72683.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657318 EMBL· GenBank· DDBJ | ABR94099.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ161177 EMBL· GenBank· DDBJ | ACR48222.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM596691 EMBL· GenBank· DDBJ | ADN11448.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU733770 EMBL· GenBank· DDBJ | ADP23024.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM238198 EMBL· GenBank· DDBJ | ADV35161.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN857035 EMBL· GenBank· DDBJ | AET09295.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC993908 EMBL· GenBank· DDBJ | AGO21789.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252388 EMBL· GenBank· DDBJ | AGX90421.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540666 EMBL· GenBank· DDBJ | AGZ07950.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF450872 EMBL· GenBank· DDBJ | AGZ64969.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF849975 EMBL· GenBank· DDBJ | AHE79563.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU521405 EMBL· GenBank· DDBJ | AMK46371.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX456666 EMBL· GenBank· DDBJ | APD55688.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272975 EMBL· GenBank· DDBJ | AVL90095.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449113 EMBL· GenBank· DDBJ | AYW06178.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP010718 EMBL· GenBank· DDBJ | BAG15134.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK128827 EMBL· GenBank· DDBJ | QBB87639.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH553658 EMBL· GenBank· DDBJ | QBY36553.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK860644 EMBL· GenBank· DDBJ | QEG54362.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT079098 EMBL· GenBank· DDBJ | QIV22230.1 EMBL· GenBank· DDBJ | Genomic DNA |