A6YVZ7 · A6YVZ7_HUMAN
- ProteinNADH-ubiquinone oxidoreductase chain 5
- GeneND5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids603 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 5
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA6YVZ7
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 84-105 | Helical | ||||
Sequence: YFSMMFIPVALFVTWSIMEFSL | ||||||
Transmembrane | 117-134 | Helical | ||||
Sequence: FFKYLLIFLITMLILVTA | ||||||
Transmembrane | 140-160 | Helical | ||||
Sequence: LFIGWEGVGIMSFLLISWWYA | ||||||
Transmembrane | 172-191 | Helical | ||||
Sequence: ILYNRIGDIGFILALAWFIL | ||||||
Transmembrane | 211-233 | Helical | ||||
Sequence: TPLLGLLLAAAGKSAQLGLHPWL | ||||||
Transmembrane | 245-266 | Helical | ||||
Sequence: ALLHSSTMVVAGIFLLIRFHPL | ||||||
Transmembrane | 272-294 | Helical | ||||
Sequence: LIQTLTLCLGAITTLFAAVCALT | ||||||
Transmembrane | 301-319 | Helical | ||||
Sequence: IVAFSTSSQLGLMMVTIGI | ||||||
Transmembrane | 325-347 | Helical | ||||
Sequence: AFLHICTHAFFKAMLFMCSGSII | ||||||
Transmembrane | 368-386 | Helical | ||||
Sequence: LTSTSLTIGSLALAGMPFL | ||||||
Transmembrane | 406-428 | Helical | ||||
Sequence: AWALSITLIATSLTSAYSTRMIL | ||||||
Transmembrane | 449-468 | Helical | ||||
Sequence: ALLNPIKRLTAGSLFAGFLI | ||||||
Transmembrane | 488-507 | Helical | ||||
Sequence: LTALAVTFLGLLTALDLNYL | ||||||
Transmembrane | 584-602 | Helical | ||||
Sequence: IKLYFLSFFFPLILTLLLI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MTMHTTMTTLTLTSLIPPILT | ||||||
Chain | PRO_5015086544 | 22-603 | NADH-ubiquinone oxidoreductase chain 5 | |||
Sequence: TLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPALLNPIKRLTAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT |
Proteomic databases
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 68-118 | NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal | ||||
Sequence: WATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFF | ||||||
Domain | 134-419 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: ANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLT | ||||||
Domain | 422-602 | NADH dehydrogenase subunit 5 C-terminal | ||||
Sequence: YSTRMILLTLTGQPRFPTLTNINENNPALLNPIKRLTAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLI |
Sequence similarities
Belongs to the complex I subunit 5 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length603
- Mass (Da)67,027
- Last updated2007-08-21 v1
- Checksum045CE05E20585331
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EF657300 EMBL· GenBank· DDBJ | ABR93877.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657569 EMBL· GenBank· DDBJ | ABR97366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU092684 EMBL· GenBank· DDBJ | ABU64326.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU092920 EMBL· GenBank· DDBJ | ABU67381.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ348161 EMBL· GenBank· DDBJ | ACJ59669.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ348162 EMBL· GenBank· DDBJ | ACJ59682.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ348163 EMBL· GenBank· DDBJ | ACJ59695.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ348164 EMBL· GenBank· DDBJ | ACJ59708.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ348165 EMBL· GenBank· DDBJ | ACJ59721.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ304740 EMBL· GenBank· DDBJ | ACT15507.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM171294 EMBL· GenBank· DDBJ | ADG46943.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM627319 EMBL· GenBank· DDBJ | ADK47663.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF812166 EMBL· GenBank· DDBJ | AEB98864.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN655829 EMBL· GenBank· DDBJ | AEQ27124.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ701859 EMBL· GenBank· DDBJ | AFF62135.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702243 EMBL· GenBank· DDBJ | AFF67127.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702338 EMBL· GenBank· DDBJ | AFF68362.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702857 EMBL· GenBank· DDBJ | AFF75109.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702929 EMBL· GenBank· DDBJ | AFF76045.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ703562 EMBL· GenBank· DDBJ | AFF84274.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ703583 EMBL· GenBank· DDBJ | AFF84547.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ703932 EMBL· GenBank· DDBJ | AFF89084.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ704103 EMBL· GenBank· DDBJ | AFF91307.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705072 EMBL· GenBank· DDBJ | AFG03904.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705094 EMBL· GenBank· DDBJ | AFG04190.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705271 EMBL· GenBank· DDBJ | AFG06491.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705322 EMBL· GenBank· DDBJ | AFG07154.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705332 EMBL· GenBank· DDBJ | AFG07284.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705394 EMBL· GenBank· DDBJ | AFG08090.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ797856 EMBL· GenBank· DDBJ | AFI50886.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ797857 EMBL· GenBank· DDBJ | AFI50899.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ797858 EMBL· GenBank· DDBJ | AFI50912.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ797859 EMBL· GenBank· DDBJ | AFI50925.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX171139 EMBL· GenBank· DDBJ | AFN87641.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153601 EMBL· GenBank· DDBJ | AFO30996.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153845 EMBL· GenBank· DDBJ | AFO34168.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC853448 EMBL· GenBank· DDBJ | AGI96873.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC911407 EMBL· GenBank· DDBJ | AGO92041.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC911436 EMBL· GenBank· DDBJ | AGO92418.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC763398 EMBL· GenBank· DDBJ | AGR43587.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC763404 EMBL· GenBank· DDBJ | AGR43665.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF161431 EMBL· GenBank· DDBJ | AGW59179.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF161966 EMBL· GenBank· DDBJ | AGW66133.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF162282 EMBL· GenBank· DDBJ | AGW70241.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ801411 EMBL· GenBank· DDBJ | AIL91211.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY275502 EMBL· GenBank· DDBJ | APG54897.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX440241 EMBL· GenBank· DDBJ | APS88967.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY587364 EMBL· GenBank· DDBJ | AQO39568.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY496915 EMBL· GenBank· DDBJ | AQX91950.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY353087 EMBL· GenBank· DDBJ | AQY77399.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY083713 EMBL· GenBank· DDBJ | ARB49030.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY782185 EMBL· GenBank· DDBJ | ASC43534.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY782231 EMBL· GenBank· DDBJ | ASC44132.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY782234 EMBL· GenBank· DDBJ | ASC44171.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY671079 EMBL· GenBank· DDBJ | ASC47686.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF621095 EMBL· GenBank· DDBJ | ATP05238.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG182037 EMBL· GenBank· DDBJ | AUD37792.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH378691 EMBL· GenBank· DDBJ | AWN02072.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH120567 EMBL· GenBank· DDBJ | AZJ09983.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK059701 EMBL· GenBank· DDBJ | QCB19331.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK491387 EMBL· GenBank· DDBJ | QEG55479.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN503433 EMBL· GenBank· DDBJ | QEW88814.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN516692 EMBL· GenBank· DDBJ | QFZ98474.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN540531 EMBL· GenBank· DDBJ | QGL54128.1 EMBL· GenBank· DDBJ | Genomic DNA |