A6YVZ7 · A6YVZ7_HUMAN

  • Protein
    NADH-ubiquinone oxidoreductase chain 5
  • Gene
    ND5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 5
  • EC number

Gene names

    • Name
      ND5
    • Synonyms
      MTND5

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • MTDNA161
    • MTDNA403
    • L318
    • L582
    • HGA
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A6YVZ7

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane84-105Helical
Transmembrane117-134Helical
Transmembrane140-160Helical
Transmembrane172-191Helical
Transmembrane211-233Helical
Transmembrane245-266Helical
Transmembrane272-294Helical
Transmembrane301-319Helical
Transmembrane325-347Helical
Transmembrane368-386Helical
Transmembrane406-428Helical
Transmembrane449-468Helical
Transmembrane488-507Helical
Transmembrane584-602Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_501508654422-603NADH-ubiquinone oxidoreductase chain 5

Proteomic databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain68-118NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Domain134-419NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain422-602NADH dehydrogenase subunit 5 C-terminal

Sequence similarities

Belongs to the complex I subunit 5 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    603
  • Mass (Da)
    67,027
  • Last updated
    2007-08-21 v1
  • Checksum
    045CE05E20585331
MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPALLNPIKRLTAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF657300
EMBL· GenBank· DDBJ
ABR93877.1
EMBL· GenBank· DDBJ
Genomic DNA
EF657569
EMBL· GenBank· DDBJ
ABR97366.1
EMBL· GenBank· DDBJ
Genomic DNA
EU092684
EMBL· GenBank· DDBJ
ABU64326.1
EMBL· GenBank· DDBJ
Genomic DNA
EU092920
EMBL· GenBank· DDBJ
ABU67381.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ348161
EMBL· GenBank· DDBJ
ACJ59669.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ348162
EMBL· GenBank· DDBJ
ACJ59682.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ348163
EMBL· GenBank· DDBJ
ACJ59695.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ348164
EMBL· GenBank· DDBJ
ACJ59708.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ348165
EMBL· GenBank· DDBJ
ACJ59721.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ304740
EMBL· GenBank· DDBJ
ACT15507.1
EMBL· GenBank· DDBJ
Genomic DNA
HM171294
EMBL· GenBank· DDBJ
ADG46943.1
EMBL· GenBank· DDBJ
Genomic DNA
HM627319
EMBL· GenBank· DDBJ
ADK47663.1
EMBL· GenBank· DDBJ
Genomic DNA
JF812166
EMBL· GenBank· DDBJ
AEB98864.1
EMBL· GenBank· DDBJ
Genomic DNA
JN655829
EMBL· GenBank· DDBJ
AEQ27124.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ701859
EMBL· GenBank· DDBJ
AFF62135.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702243
EMBL· GenBank· DDBJ
AFF67127.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702338
EMBL· GenBank· DDBJ
AFF68362.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702857
EMBL· GenBank· DDBJ
AFF75109.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702929
EMBL· GenBank· DDBJ
AFF76045.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ703562
EMBL· GenBank· DDBJ
AFF84274.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ703583
EMBL· GenBank· DDBJ
AFF84547.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ703932
EMBL· GenBank· DDBJ
AFF89084.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ704103
EMBL· GenBank· DDBJ
AFF91307.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705072
EMBL· GenBank· DDBJ
AFG03904.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705094
EMBL· GenBank· DDBJ
AFG04190.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705271
EMBL· GenBank· DDBJ
AFG06491.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705322
EMBL· GenBank· DDBJ
AFG07154.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705332
EMBL· GenBank· DDBJ
AFG07284.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705394
EMBL· GenBank· DDBJ
AFG08090.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ797856
EMBL· GenBank· DDBJ
AFI50886.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ797857
EMBL· GenBank· DDBJ
AFI50899.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ797858
EMBL· GenBank· DDBJ
AFI50912.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ797859
EMBL· GenBank· DDBJ
AFI50925.1
EMBL· GenBank· DDBJ
Genomic DNA
JX171139
EMBL· GenBank· DDBJ
AFN87641.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153601
EMBL· GenBank· DDBJ
AFO30996.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153845
EMBL· GenBank· DDBJ
AFO34168.1
EMBL· GenBank· DDBJ
Genomic DNA
KC853448
EMBL· GenBank· DDBJ
AGI96873.1
EMBL· GenBank· DDBJ
Genomic DNA
KC911407
EMBL· GenBank· DDBJ
AGO92041.1
EMBL· GenBank· DDBJ
Genomic DNA
KC911436
EMBL· GenBank· DDBJ
AGO92418.1
EMBL· GenBank· DDBJ
Genomic DNA
KC763398
EMBL· GenBank· DDBJ
AGR43587.1
EMBL· GenBank· DDBJ
Genomic DNA
KC763404
EMBL· GenBank· DDBJ
AGR43665.1
EMBL· GenBank· DDBJ
Genomic DNA
KF161431
EMBL· GenBank· DDBJ
AGW59179.1
EMBL· GenBank· DDBJ
Genomic DNA
KF161966
EMBL· GenBank· DDBJ
AGW66133.1
EMBL· GenBank· DDBJ
Genomic DNA
KF162282
EMBL· GenBank· DDBJ
AGW70241.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ801411
EMBL· GenBank· DDBJ
AIL91211.1
EMBL· GenBank· DDBJ
Genomic DNA
KY275502
EMBL· GenBank· DDBJ
APG54897.1
EMBL· GenBank· DDBJ
Genomic DNA
KX440241
EMBL· GenBank· DDBJ
APS88967.1
EMBL· GenBank· DDBJ
Genomic DNA
KY587364
EMBL· GenBank· DDBJ
AQO39568.1
EMBL· GenBank· DDBJ
Genomic DNA
KY496915
EMBL· GenBank· DDBJ
AQX91950.1
EMBL· GenBank· DDBJ
Genomic DNA
KY353087
EMBL· GenBank· DDBJ
AQY77399.1
EMBL· GenBank· DDBJ
Genomic DNA
KY083713
EMBL· GenBank· DDBJ
ARB49030.1
EMBL· GenBank· DDBJ
Genomic DNA
KY782185
EMBL· GenBank· DDBJ
ASC43534.1
EMBL· GenBank· DDBJ
Genomic DNA
KY782231
EMBL· GenBank· DDBJ
ASC44132.1
EMBL· GenBank· DDBJ
Genomic DNA
KY782234
EMBL· GenBank· DDBJ
ASC44171.1
EMBL· GenBank· DDBJ
Genomic DNA
KY671079
EMBL· GenBank· DDBJ
ASC47686.1
EMBL· GenBank· DDBJ
Genomic DNA
MF621095
EMBL· GenBank· DDBJ
ATP05238.1
EMBL· GenBank· DDBJ
Genomic DNA
MG182037
EMBL· GenBank· DDBJ
AUD37792.1
EMBL· GenBank· DDBJ
Genomic DNA
MH378691
EMBL· GenBank· DDBJ
AWN02072.1
EMBL· GenBank· DDBJ
Genomic DNA
MH120567
EMBL· GenBank· DDBJ
AZJ09983.1
EMBL· GenBank· DDBJ
Genomic DNA
MK059701
EMBL· GenBank· DDBJ
QCB19331.1
EMBL· GenBank· DDBJ
Genomic DNA
MK491387
EMBL· GenBank· DDBJ
QEG55479.1
EMBL· GenBank· DDBJ
Genomic DNA
MN503433
EMBL· GenBank· DDBJ
QEW88814.1
EMBL· GenBank· DDBJ
Genomic DNA
MN516692
EMBL· GenBank· DDBJ
QFZ98474.1
EMBL· GenBank· DDBJ
Genomic DNA
MN540531
EMBL· GenBank· DDBJ
QGL54128.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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