A6YLR3 · A6YLR3_HORSE

  • Protein
    Cellular tumor antigen p53
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site.

1142102030405060708090100110120130140
TypeIDPosition(s)Description
Binding site36Zn2+ (UniProtKB | ChEBI)
Binding site39Zn2+ (UniProtKB | ChEBI)
Binding site99Zn2+ (UniProtKB | ChEBI)
Binding site103Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentendoplasmic reticulum
Cellular Componentmitochondrial matrix
Cellular ComponentPML body
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionmetal ion binding
Molecular Functiontranscription cis-regulatory region binding
Biological Processapoptotic process
Biological Processrhythmic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cellular tumor antigen p53

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    A6YLR3

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Binds DNA as a homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-142p53 DNA-binding

Sequence similarities

Belongs to the p53 family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    142
  • Mass (Da)
    15,936
  • Last updated
    2007-08-21 v1
  • MD5 Checksum
    75259359C87F2ED3AD6AEF6DDE2D32F4
CPVQLWVSSPPPPGTRVRAMAIYKKSEFMTEVVRRCPHHERCSDSSDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNFMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue142

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF627477
EMBL· GenBank· DDBJ
ABR88131.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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