A6YAR7 · A6YAR7_CAMFR
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids514 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Tylopoda > Camelidae > Camelus
Accessions
- Primary accessionA6YAR7
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 18-37 | Helical | |||
Transmembrane | 57-83 | Helical | |||
Transmembrane | 104-128 | Helical | |||
Transmembrane | 148-171 | Helical | |||
Transmembrane | 183-210 | Helical | |||
Transmembrane | 243-261 | Helical | |||
Transmembrane | 268-291 | Helical | |||
Transmembrane | 303-325 | Helical | |||
Transmembrane | 337-359 | Helical | |||
Transmembrane | 379-400 | Helical | |||
Transmembrane | 412-430 | Helical | |||
Transmembrane | 450-473 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-514 | Cytochrome oxidase subunit I profile | |||
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length514
- Mass (Da)56,906
- Last updated2007-10-02 v2
- Checksum922A4C5F76B607CC
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EF212038 EMBL· GenBank· DDBJ | ABM65789.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF507801 EMBL· GenBank· DDBJ | ABO70710.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU666451 EMBL· GenBank· DDBJ | AOR39703.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU666452 EMBL· GenBank· DDBJ | AOR39716.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU666453 EMBL· GenBank· DDBJ | AOR39729.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU666454 EMBL· GenBank· DDBJ | AOR39742.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU666455 EMBL· GenBank· DDBJ | AOR39755.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU666456 EMBL· GenBank· DDBJ | AOR39768.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU666457 EMBL· GenBank· DDBJ | AOR39781.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU666458 EMBL· GenBank· DDBJ | AOR39794.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU666459 EMBL· GenBank· DDBJ | AOR39807.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109912 EMBL· GenBank· DDBJ | AZQ06515.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109913 EMBL· GenBank· DDBJ | AZQ06528.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109914 EMBL· GenBank· DDBJ | AZQ06541.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109915 EMBL· GenBank· DDBJ | AZQ06554.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109916 EMBL· GenBank· DDBJ | AZQ06567.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109917 EMBL· GenBank· DDBJ | AZQ06580.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109918 EMBL· GenBank· DDBJ | AZQ06593.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109919 EMBL· GenBank· DDBJ | AZQ06606.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109920 EMBL· GenBank· DDBJ | AZQ06619.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109921 EMBL· GenBank· DDBJ | AZQ06632.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109922 EMBL· GenBank· DDBJ | AZQ06645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109923 EMBL· GenBank· DDBJ | AZQ06658.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109924 EMBL· GenBank· DDBJ | AZQ06671.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109925 EMBL· GenBank· DDBJ | AZQ06684.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109926 EMBL· GenBank· DDBJ | AZQ06697.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109927 EMBL· GenBank· DDBJ | AZQ06710.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109928 EMBL· GenBank· DDBJ | AZQ06723.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109929 EMBL· GenBank· DDBJ | AZQ06736.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH109930 EMBL· GenBank· DDBJ | AZQ06749.1 EMBL· GenBank· DDBJ | Genomic DNA |