A6YAR7 · A6YAR7_CAMFR

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI
    • Synonyms
      COX1

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A6YAR7
  • Secondary accessions
    • A7KP88

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-37Helical
Transmembrane57-83Helical
Transmembrane104-128Helical
Transmembrane148-171Helical
Transmembrane183-210Helical
Transmembrane243-261Helical
Transmembrane268-291Helical
Transmembrane303-325Helical
Transmembrane337-359Helical
Transmembrane379-400Helical
Transmembrane412-430Helical
Transmembrane450-473Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-514Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    514
  • Mass (Da)
    56,906
  • Last updated
    2007-10-02 v2
  • Checksum
    922A4C5F76B607CC
MFITRWLFSTNHKDIGTLYLLFGAWAGMVGMGLSLLIRAELGQPGTLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFMHWFPLFSGYTIDDTWAKIQFAIMFVGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNTISSVGSFISLTAVVLMVFIVWEAFASKREVTTVELTATNLEWLHGCPPPYHTFEEPTYINLK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF212038
EMBL· GenBank· DDBJ
ABM65789.2
EMBL· GenBank· DDBJ
Genomic DNA
EF507801
EMBL· GenBank· DDBJ
ABO70710.1
EMBL· GenBank· DDBJ
Genomic DNA
KU666451
EMBL· GenBank· DDBJ
AOR39703.1
EMBL· GenBank· DDBJ
Genomic DNA
KU666452
EMBL· GenBank· DDBJ
AOR39716.1
EMBL· GenBank· DDBJ
Genomic DNA
KU666453
EMBL· GenBank· DDBJ
AOR39729.1
EMBL· GenBank· DDBJ
Genomic DNA
KU666454
EMBL· GenBank· DDBJ
AOR39742.1
EMBL· GenBank· DDBJ
Genomic DNA
KU666455
EMBL· GenBank· DDBJ
AOR39755.1
EMBL· GenBank· DDBJ
Genomic DNA
KU666456
EMBL· GenBank· DDBJ
AOR39768.1
EMBL· GenBank· DDBJ
Genomic DNA
KU666457
EMBL· GenBank· DDBJ
AOR39781.1
EMBL· GenBank· DDBJ
Genomic DNA
KU666458
EMBL· GenBank· DDBJ
AOR39794.1
EMBL· GenBank· DDBJ
Genomic DNA
KU666459
EMBL· GenBank· DDBJ
AOR39807.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109912
EMBL· GenBank· DDBJ
AZQ06515.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109913
EMBL· GenBank· DDBJ
AZQ06528.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109914
EMBL· GenBank· DDBJ
AZQ06541.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109915
EMBL· GenBank· DDBJ
AZQ06554.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109916
EMBL· GenBank· DDBJ
AZQ06567.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109917
EMBL· GenBank· DDBJ
AZQ06580.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109918
EMBL· GenBank· DDBJ
AZQ06593.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109919
EMBL· GenBank· DDBJ
AZQ06606.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109920
EMBL· GenBank· DDBJ
AZQ06619.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109921
EMBL· GenBank· DDBJ
AZQ06632.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109922
EMBL· GenBank· DDBJ
AZQ06645.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109923
EMBL· GenBank· DDBJ
AZQ06658.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109924
EMBL· GenBank· DDBJ
AZQ06671.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109925
EMBL· GenBank· DDBJ
AZQ06684.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109926
EMBL· GenBank· DDBJ
AZQ06697.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109927
EMBL· GenBank· DDBJ
AZQ06710.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109928
EMBL· GenBank· DDBJ
AZQ06723.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109929
EMBL· GenBank· DDBJ
AZQ06736.1
EMBL· GenBank· DDBJ
Genomic DNA
MH109930
EMBL· GenBank· DDBJ
AZQ06749.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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