A6XDB1 · A6XDB1_MOUSE

  • Protein
    Phosphodiesterase
  • Gene
    Pde4d
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Pathway

Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site158Proton donor
Binding site158-162AMP (UniProtKB | ChEBI)
Binding site162Zn2+ 1 (UniProtKB | ChEBI)
Binding site198Zn2+ 1 (UniProtKB | ChEBI)
Binding site199AMP (UniProtKB | ChEBI)
Binding site199Zn2+ 1 (UniProtKB | ChEBI)
Binding site199Zn2+ 2 (UniProtKB | ChEBI)
Binding site316AMP (UniProtKB | ChEBI)
Binding site316Zn2+ 1 (UniProtKB | ChEBI)
Binding site367AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3',5'-cyclic-AMP phosphodiesterase activity
Molecular Functionmetal ion binding
Biological ProcesscAMP catabolic process
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      Pde4d

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Swiss Webster
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    A6XDB1

Proteomes

Organism-specific databases

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region39-60Disordered
Compositional bias41-58Basic and acidic residues
Domain82-411PDEase
Region406-504Disordered
Compositional bias421-436Basic and acidic residues
Compositional bias454-473Polar residues
Compositional bias474-494Acidic residues

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    504
  • Mass (Da)
    57,578
  • Last updated
    2007-08-21 v1
  • Checksum
    4AF93CD989A6A125
MSKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDQEEGRQGQTEKFQFELTLEEDCESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVAEEESQPETCVPDDCCPDT

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q01063PDE4D_MOUSEPde4d747
F7BK43F7BK43_MOUSEPde4d48
E9PVU7E9PVU7_MOUSEPde4d803
F6QFD1F6QFD1_MOUSEPde4d754
B1PSD9B1PSD9_MOUSEPde4d698
A6XDB0A6XDB0_MOUSEPde4d517
F6YIS2F6YIS2_MOUSEPde4d207
B2KF57B2KF57_MOUSEPde4d700
B2KF84B2KF84_MOUSEPde4d703

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias41-58Basic and acidic residues
Compositional bias421-436Basic and acidic residues
Compositional bias454-473Polar residues
Compositional bias474-494Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ665896
EMBL· GenBank· DDBJ
ABG57277.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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