A6W572 · UPP_KINRD

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site785-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1035-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site130-1385-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site196uracil (UniProtKB | ChEBI)
Binding site201-203uracil (UniProtKB | ChEBI)
Binding site2025-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • Ordered locus names
      Krad_0471

Organism names

Accessions

  • Primary accession
    A6W572

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000856291-211Uracil phosphoribosyltransferase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    211
  • Mass (Da)
    22,609
  • Last updated
    2007-08-21 v1
  • Checksum
    F80F6BDF7D72A5BC
MRLSVIDHPLVAHKLTALRDARTDSPTFRRLADELVTLLAYEATRDVAVEPHPVTTPVTATTGVRLTSPKPIVVPILRAGLGMLDGMVRLLPTAEVGFLGMIRDETTLQATTYANRLPDDLSGRQVFVLDPMLATGGTLVAAITYLLERGARDVTALCLLAAPEGLEVVRTAFDDHAQVTVVTAAVDERLDENGYIVPGLGDAGDRLYGVV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000750
EMBL· GenBank· DDBJ
ABS01961.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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