A6W572 · UPP_KINRD
- ProteinUracil phosphoribosyltransferase
- Geneupp
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids211 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Catalytic activity
- UMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + uracil
Cofactor
Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.
Activity regulation
Allosterically activated by GTP.
Pathway
Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 78 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 103 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 130-138 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 196 | uracil (UniProtKB | ChEBI) | |||
Binding site | 201-203 | uracil (UniProtKB | ChEBI) | |||
Binding site | 202 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | GTP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | uracil phosphoribosyltransferase activity | |
Biological Process | UMP salvage | |
Biological Process | uracil salvage |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUracil phosphoribosyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kineosporiales > Kineosporiaceae > Kineococcus
Accessions
- Primary accessionA6W572
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000085629 | 1-211 | Uracil phosphoribosyltransferase | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length211
- Mass (Da)22,609
- Last updated2007-08-21 v1
- ChecksumF80F6BDF7D72A5BC
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000750 EMBL· GenBank· DDBJ | ABS01961.1 EMBL· GenBank· DDBJ | Genomic DNA |