A6W3C7 · TRMA_MARMS

Function

function

Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).

Catalytic activity

Features

Showing features for binding site, active site.

136650100150200250300350
TypeIDPosition(s)Description
Binding site187S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site215S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site220S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site236S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site297S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site322Nucleophile
Active site356Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionrRNA binding
Molecular FunctiontRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent
Molecular FunctiontRNA binding
Biological ProcesstRNA methylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA/tmRNA (uracil-C(5))-methyltransferase
  • EC number
  • Alternative names
    • tRNA (uracil(54)-C(5))-methyltransferase
    • tRNA(m5U54)-methyltransferase
      (RUMT
      )
    • tmRNA (uracil(341)-C(5))-methyltransferase

Gene names

    • Name
      trmA
    • Ordered locus names
      Mmwyl1_4311

Organism names

Accessions

  • Primary accession
    A6W3C7

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000840371-366tRNA/tmRNA (uracil-C5)-methyltransferase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    366
  • Mass (Da)
    41,398
  • Last updated
    2007-08-21 v1
  • Checksum
    FBA44BD478D16207
MRPDQIQPEMYEKQLQDKQAELAKLMATLSLPEMEVFASQPTHYRMRAEFRIWHDGDDLYYAMFDSADPRTPIRTDQFLAASRLINELMPKLLDAVRDVPVLRYKLFQVDFLTTTTGEALISLLYHKPIDAEWNAAVQQLNNAFPACHFIGRSRKKKQIITRDFVMETLTVNGQKFHYQQVENSFTQPNAGISEKMLEWALDVTKEASGDLLEMYCGNGNFSIPLARRFDRVVATEISKVSVNSAQLNIAINGMHNVQVVKMASEDVSAALNGDVELPKSLVQAGVSELTPSVVLVDPPRAGLDDATVELIRKIDSILYISCNPETLKANLEALSNTHEVVRYAMFDQFPYTHHVETGVFLRRKAS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000749
EMBL· GenBank· DDBJ
ABR73206.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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