A6W2P7 · BETB_MARMS
- ProteinBetaine aldehyde dehydrogenase
- GenebetB
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids485 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
Catalytic activity
- betaine aldehyde + H2O + NAD+ = glycine betaine + 2 H+ + NADHThis reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 potassium ions per subunit.
Pathway
Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 23 | K+ 1 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 24 | K+ 1 (UniProtKB | ChEBI) | ||||
Sequence: I | ||||||
Binding site | 90 | K+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 147-149 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GAW | ||||||
Active site | 159 | Charge relay system | ||||
Sequence: K | ||||||
Binding site | 173-176 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: KPSE | ||||||
Binding site | 226-229 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: EVGT | ||||||
Binding site | 241 | K+ 2 (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Active site | 247 | Proton acceptor | ||||
Sequence: E | ||||||
Binding site | 249 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Active site | 281 | Nucleophile | ||||
Sequence: C | ||||||
Binding site | 281 | NAD+ (UniProtKB | ChEBI); covalent | ||||
Sequence: C | ||||||
Binding site | 382 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 452 | K+ 2 (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 455 | K+ 2 (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Active site | 459 | Charge relay system | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | betaine-aldehyde dehydrogenase activity | |
Molecular Function | metal ion binding | |
Biological Process | glycine betaine biosynthetic process from choline |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBetaine aldehyde dehydrogenase
- EC number
- Short namesBADH
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Oceanospirillaceae > Marinomonas
Accessions
- Primary accessionA6W2P7
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000083709 | 1-485 | Betaine aldehyde dehydrogenase | |||
Sequence: MAHQQQYIHGRYHASTSGEHFETINPATGEVIATVEHAGQAELDAAVESAKQGQKVWSAMSPVERGRILKKAAELLRENNEELARLEVLDTGKPLQEAIVVDIQTGADVIEYYAGLTDKIQGDYQDLGNGNFFYTRREPLGICAGIGAWNYPIQIAMWKSGPALAAGNAMIFKPSEETPLTALKLAEIFTEAGLPDGVFNVIQGDARTGQLITNHPDIDKVSFTGEVGTGKKVMAASAQSLKQVTMELGGKSPMIIFPDMPVDQAVSAAMLANFYTQGEVCTNGTRVFVHADMLDAFTKELKQRTEAMIIGDPMDMDTQVGALISKDHMQKVLGYIQAAKDAGATLLCGGYQVTENGLDKGAFVAPTVFTDCTDDMPQVRDEIFGPVMSVLSFTDEDEVIARANDTKLGLAAGVFTKDFARAHRVINQLQAGICWINSWGASPAEMPVGGYKQSGIGRENGIETLYHYTQNKSVFVDLNDIQSPY | ||||||
Modified residue | 281 | Cysteine sulfenic acid (-SOH) | ||||
Sequence: C |
Keywords
- PTM
Interaction
Structure
Sequence
- Sequence statusComplete
- Length485
- Mass (Da)52,554
- Last updated2007-08-21 v1
- Checksum7232C7ABBD5185DC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000749 EMBL· GenBank· DDBJ | ABR72976.1 EMBL· GenBank· DDBJ | Genomic DNA |