A6W2I3 · PANB_MARMS

Function

function

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site55Mg2+ (UniProtKB | ChEBI)
Binding site55-563-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site943-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site94Mg2+ (UniProtKB | ChEBI)
Binding site1223-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site124Mg2+ (UniProtKB | ChEBI)
Active site191Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Molecular Functionmagnesium ion binding
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-methyl-2-oxobutanoate hydroxymethyltransferase
  • EC number
  • Alternative names
    • Ketopantoate hydroxymethyltransferase
      (KPHMT
      )

Gene names

    • Name
      panB
    • Ordered locus names
      Mmwyl1_4016

Organism names

Accessions

  • Primary accession
    A6W2I3

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000969821-2753-methyl-2-oxobutanoate hydroxymethyltransferase

Interaction

Subunit

Homodecamer; pentamer of dimers.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the PanB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    275
  • Mass (Da)
    29,642
  • Last updated
    2007-08-21 v1
  • Checksum
    ED111BE38D315D3E
MYSDNSQRKLTKAVTLSTLKKMKADKEKITCLTSYDASFTNVMNVAGVETILVGDSLGMVIQGQDSTLPVTIEDMCYHTAAVKRGNTNAFILADMSFMSYSKPEQALDNAAKLMQAGANMVKLEGGSWLADTIKLLSQRGIPVCAHLGLTPQSVHKFGGYKVQGKSQDAADLLLQESLDLVAAGADILLYECIPTELGKTLTDAVPVPTIGIGAGHHTDGQVLVMHDMLGINLGHTPKFVKNFLTEGRNVTEAFEAYVKEVKDMTFPGPEHGFKS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000749
EMBL· GenBank· DDBJ
ABR72912.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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