A6VX14 · RRAAH_MARMS

Function

function

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Divalent metal cation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site75-78substrate
Binding site97substrate
Binding site98a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
Molecular Functionmetal ion binding
Molecular Functionoxaloacetate decarboxylase activity
Molecular Functionribonuclease inhibitor activity
Biological Processregulation of RNA metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • EC number
  • Short names
    HMG aldolase
  • Alternative names
    • Oxaloacetate decarboxylase (OAA decarboxylase) (EC:4.1.1.112) . EC:4.1.1.112 (UniProtKB | ENZYME | Rhea)
    • Regulator of ribonuclease activity homolog
    • RraA-like protein

Gene names

    • Ordered locus names
      Mmwyl1_2071

Organism names

Accessions

  • Primary accession
    A6VX14

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000812081-161Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the class II aldolase/RraA-like family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    161
  • Mass (Da)
    17,525
  • Last updated
    2007-08-21 v1
  • Checksum
    C1815EE90CBE063E
MKDLLPDLCDLYPEKLQIAEPIFTSYGKRSHFYGEVVTVSCFEDNSRVRELVAENGKGKVMVIDGGGSKRRALLGDMLAEKAVDNGWEGFVINGAIRDIAAQSQLNIGIHALCAHPMPTEKRGLGDLGKTLRFAGMTIAQGDYIYCDLNGIVVSKQPLALP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000749
EMBL· GenBank· DDBJ
ABR70993.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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