A6VVN4 · KATG_MARMS

Function

function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.

Features

Showing features for site, active site, binding site.

TypeIDPosition(s)Description
Site100Transition state stabilizer
Active site104Proton acceptor
Binding site267Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncatalase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processcellular response to hydrogen peroxide
Biological Processhydrogen peroxide catabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Catalase-peroxidase
  • EC number
  • Short names
    CP
  • Alternative names
    • Peroxidase/catalase

Gene names

    • Name
      katG
    • Ordered locus names
      Mmwyl1_1585

Organism names

Accessions

  • Primary accession
    A6VVN4

Subcellular Location

PTM/Processing

Features

Showing features for chain, cross-link.

TypeIDPosition(s)Description
ChainPRO_00003548291-737Catalase-peroxidase
Cross-link103↔226Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-252)
Cross-link226↔252Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-103)

Post-translational modification

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.

Interaction

Subunit

Homodimer or homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-32Disordered
Compositional bias17-32Polar residues

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    737
  • Mass (Da)
    81,182
  • Last updated
    2007-08-21 v1
  • Checksum
    C16560A20E762F15
MSKENMSNEGKCPFNHGAAGTNQSSGRGTSNKDWWPNQLNLNILHQHSPKSNPMGEDFDYAKEFNSLDLEAIRQDLFALMTDSQDWWPADYGHYGPFFIRMAWHSAGTYRTADGRGGATSGTQRFAPLNSWPDNVNLDKARRLLWPIKQKYGRKISWADLMILAGNCALESMGFKTFGFAGGRVDVWQPEEDIYWGTEKTWLDDERYTGDRELENPLAAVQMGLIYVNPEGPEGKPDTLASARDIRDTFGRMAMNDEETVALIAGGHTFGKAHGAGDAAQVGADPEAAGIAEQGFGWSNSMGTGKGVDTISSGLEGAWTKSPIAWDNGYFENLFEYDWELTKSPAGAWQWTPKDGAAANSVPDAHDSSKRHAPIMFTSDLALRDDPIYAPISKRFYENPDQLADAFARAWFKLTHRDMGPVARYLGPLVPQEELVWQDPIPAVTYVTVNDQDILDLKAKIQASGLTVAQLVSTAWASASTYRGSDMRGGANGARIRLAPQKDWAVNQPEQLAKVLSVLESIQAEFNRQDSTKQVSLADLIVLGGSVGVEQAAKASGHSVTVPFTAGRADASQEQTDVESFAFLEPAADGFRNYLKGKYTVSAEEMLVDRAQLLTLSAPEMTALLGGLRVLNANVGQSQHGVFTDKPETLSNDFFVNLLDMGTKWFATSEEEEEFQGRDRTTGKIKWTATRADLVFGSNSQLRAIAEVYACSDSQERFVKDFIAAWTKVMELDRFDLA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias17-32Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000749
EMBL· GenBank· DDBJ
ABR70513.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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