A6VUP4 · A6VUP4_MARMS

Function

function

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

Catalytic activity

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site19-24GTP (UniProtKB | ChEBI)
Binding site136-139GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionguanosine tetraphosphate binding
Molecular Functionribosome binding
Molecular Functiontranslation elongation factor activity
Biological Processpositive regulation of translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation factor 4
  • EC number
  • Short names
    EF-4
  • Alternative names
    • Ribosomal back-translocase LepA

Gene names

    • Name
      lepA
    • Ordered locus names
      Mmwyl1_1244

Organism names

  • Taxonomic identifier
  • Strain
    • MWYL1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Oceanospirillaceae > Marinomonas

Accessions

  • Primary accession
    A6VUP4

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-189Tr-type G

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    601
  • Mass (Da)
    66,532
  • Last updated
    2007-08-21 v1
  • Checksum
    65D1C390958ADA18
MSSNNLKHIRNFSIIAHIDHGKSTLADRFIQTCEGLSEREMSAQVLDSMDIERERGITIKAQSVTLDYHAKDGQVYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAAQGVEAQSVANCYTAIEQGLEVMPVLNKIDLPQAEPERVSAEIEEIIGIDAMNAVTCSAKTGMGVDDVLERLVATIPPPEGDVDAPLQALIIDSWFDNYLGVVSLVRIKQGTLRKKDKIYIKSTKMSHPVDMAGIFTPKRKETGVLRAGEVGYVVAGIKDIHGAPVGDTITHTSTPDVPQLAGFQKVKPQVYAGVFPVSSDQYEDFRVALDKLTLNDASLFFEPESSDALGFGFRCGFLGMLHMEIIQERLEREYDLDLITTAPTVVFEVELNNGDVINVDSPSKMPDPGTIKEMREPIVEANILVPQEYLGNVITLCVEKRGIQKDMLYVGRQVQLRYQLPMNEVVMDFFDKLKSCSRGFASLDYSFSHFSPAPLCRLDILINGERVDALALIMHKDNVQFRGRALCEKMKDLIPRQMFDVAIQGAVGAKVISRTTVKALRKNVIAKCYGGDVSRKKKLLQKQKEGKKRMKQVGNVEVPQSAFLAVLQLDS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000749
EMBL· GenBank· DDBJ
ABR70173.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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