A6VUP4 · A6VUP4_MARMS
- ProteinElongation factor 4
- GenelepA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids601 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.
Catalytic activity
- GTP + H2O = GDP + H+ + phosphate
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | guanosine tetraphosphate binding | |
Molecular Function | ribosome binding | |
Molecular Function | translation elongation factor activity | |
Biological Process | positive regulation of translation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameElongation factor 4
- EC number
- Short namesEF-4
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Oceanospirillaceae > Marinomonas
Accessions
- Primary accessionA6VUP4
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-189 | Tr-type G | ||||
Sequence: KHIRNFSIIAHIDHGKSTLADRFIQTCEGLSEREMSAQVLDSMDIERERGITIKAQSVTLDYHAKDGQVYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAAQGVEAQSVANCYTAIEQGLEVMPVLNKIDLPQAEPERVSAEIEEIIGIDAMNAVTCSAKTGMGVDDVLERLVATIPPPE |
Sequence similarities
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length601
- Mass (Da)66,532
- Last updated2007-08-21 v1
- Checksum65D1C390958ADA18
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000749 EMBL· GenBank· DDBJ | ABR70173.1 EMBL· GenBank· DDBJ | Genomic DNA |