A6V6F5 · HGD_PSEA7

Function

function

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site287Proton acceptor
Binding site330Fe cation (UniProtKB | ChEBI)
Binding site336Fe cation (UniProtKB | ChEBI)
Binding site345homogentisate (UniProtKB | ChEBI)
Binding site366Fe cation (UniProtKB | ChEBI)
Binding site366homogentisate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionhomogentisate 1,2-dioxygenase activity
Molecular Functioniron ion binding
Biological ProcessL-phenylalanine catabolic process
Biological Processtyrosine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homogentisate 1,2-dioxygenase
  • EC number
  • Short names
    HGDO
  • Alternative names
    • Homogentisate oxygenase
    • Homogentisic acid oxidase
    • Homogentisicase

Gene names

    • Name
      hmgA
    • Ordered locus names
      PSPA7_3280

Organism names

Accessions

  • Primary accession
    A6V6F5

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000195321-432Homogentisate 1,2-dioxygenase

Interaction

Subunit

Hexamer; dimer of trimers.

Structure

Family & Domains

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    432
  • Mass (Da)
    47,879
  • Last updated
    2007-08-21 v1
  • MD5 Checksum
    1A61957DC5A8EA8AC8438F0B811B5C92
MNLDSTALAYQSGFGNEFSSEALPGALPVGQNSPQKAPYGLYAELLSGTAFTMARSEARRTWLYRITPSAKHPPFRRLERQIAGAELDAPTPNRLRWDPLALPEQPTDFLDGLLRMAANAPGDKPAGVSIYQYLANRSMERCFYDADGELLLVPQLGRLRLCTELGALQVEPLEIAVIPRGMKFRVELLDGEARGYIAENHGAPLRLPDLGPIGSNGLANPRDFLAPVARYEDSRQPLQLVQKYLGELWACELDHSPLDVVAWHGNNVPYKYDLRRFNTIGTVSFDHPDPSIFTVLTSPTSVHGLANIDFVIFPPRWMVAENTFRPPWFHRNLMNEFMGLIQGAYDAKAGGFVPGGASLHSCMSAHGPDAESCDKAIAADLRPHRIDQTMAFMFETSQVLRPSRAALETPALQNDYDACWASLVSTFNPQRR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000744
EMBL· GenBank· DDBJ
ABR82657.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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