A6UVC9 · GUAAA_META3
- ProteinGMP synthase [glutamine-hydrolyzing] subunit A
- GeneguaAA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids188 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the synthesis of GMP from XMP.
Catalytic activity
- ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H+ + L-glutamate
Pathway
Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 76 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 163 | |||||
Sequence: H | ||||||
Active site | 165 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | GMP synthase activity | |
Biological Process | glutamine metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGMP synthase [glutamine-hydrolyzing] subunit A
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanococci > Methanococcales > Methanococcaceae > Methanococcus
Accessions
- Primary accessionA6UVC9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000316093 | 1-188 | GMP synthase [glutamine-hydrolyzing] subunit A | |||
Sequence: MIVILNNGGQYVHRIHRSLRYLKIPSKIIPNSTPLAEIEENKEIKGIILSGGPDIEKASNCLDIALNSKLPILGICLGHQIIAKAYGGEIGRAESEEYAHSKIFVKEENDLFKNVPKEFTAWASHKDEVVGAPLNFEILAYSNICEVEAMKHKEKPIYGVQFHPEVSHTENGAEILKNFCKVCGLLGE |
Interaction
Subunit
Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-188 | Glutamine amidotransferase type-1 | ||||
Sequence: MIVILNNGGQYVHRIHRSLRYLKIPSKIIPNSTPLAEIEENKEIKGIILSGGPDIEKASNCLDIALNSKLPILGICLGHQIIAKAYGGEIGRAESEEYAHSKIFVKEENDLFKNVPKEFTAWASHKDEVVGAPLNFEILAYSNICEVEAMKHKEKPIYGVQFHPEVSHTENGAEILKNFCKVCGLLGE |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length188
- Mass (Da)20,877
- Last updated2007-08-21 v1
- Checksum2540A7E6E98378CC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000743 EMBL· GenBank· DDBJ | ABR56451.1 EMBL· GenBank· DDBJ | Genomic DNA |