A6TFQ6 · A6TFQ6_KLEP7
- ProteinTriosephosphate isomerase
- GenetpiA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids249 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Catalytic activity
- D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
Pathway
Carbohydrate biosynthesis; gluconeogenesis.
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
Carbohydrate metabolism; erythritol degradation.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 3-5 | substrate | ||||
Sequence: NWK | ||||||
Active site | 89 | Electrophile | ||||
Sequence: H | ||||||
Active site | 161 | Proton acceptor | ||||
Sequence: E | ||||||
Binding site | 167 | substrate | ||||
Sequence: G | ||||||
Binding site | 206 | substrate | ||||
Sequence: S | ||||||
Binding site | 227-228 | substrate | ||||
Sequence: GG |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | triose-phosphate isomerase activity | |
Biological Process | gluconeogenesis | |
Biological Process | glyceraldehyde-3-phosphate biosynthetic process | |
Biological Process | glycerol catabolic process | |
Biological Process | glycolytic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTriosephosphate isomerase
- EC number
- Short namesTIM ; TPI
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA6TFQ6
Proteomes
Subcellular Location
Interaction
Structure
Sequence
- Sequence statusComplete
- Length249
- Mass (Da)26,176
- Last updated2007-08-21 v1
- ChecksumC724DEDEE7EBA911
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000647 EMBL· GenBank· DDBJ | ABR79390.1 EMBL· GenBank· DDBJ | Genomic DNA |