A6T6Q6 · DPS_KLEP7
- ProteinDNA protection during starvation protein
- Genedps
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids167 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
Catalytic activity
- 2 Fe2+ + H2O2 + 2 H+ = 2 Fe3+ + 2 H2O
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 51 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 78 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 82 | Fe cation (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | DNA binding | |
Molecular Function | ferric iron binding | |
Molecular Function | oxidoreductase activity, acting on metal ions | |
Biological Process | chromosome condensation | |
Biological Process | intracellular iron ion homeostasis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA protection during starvation protein
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA6T6Q6
Proteomes
Subcellular Location
Interaction
Subunit
Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe3+ can be deposited.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length167
- Mass (Da)18,708
- Last updated2007-08-21 v1
- MD5 ChecksumA21712424CDF5B70FDF31533C7D74BBC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000647 EMBL· GenBank· DDBJ | ABR76277.1 EMBL· GenBank· DDBJ | Genomic DNA |