A6T4X5 · A6T4X5_KLEP7

Function

function

Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site10NADPH (UniProtKB | ChEBI)
Binding site11NADPH (UniProtKB | ChEBI)
Binding site12NADPH (UniProtKB | ChEBI)
Binding site13NADPH (UniProtKB | ChEBI)
Binding site36NADPH (UniProtKB | ChEBI)
Binding site37NADPH (UniProtKB | ChEBI)
Binding site38NADPH (UniProtKB | ChEBI)
Binding site124NADPH (UniProtKB | ChEBI)
Binding site1251-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site126NADPH (UniProtKB | ChEBI)
Binding site150Mn2+ (UniProtKB | ChEBI)
Binding site1511-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1521-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site152Mn2+ (UniProtKB | ChEBI)
Binding site1861-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2091-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site215NADPH (UniProtKB | ChEBI)
Binding site2221-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2271-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2281-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2311-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site231Mn2+ (UniProtKB | ChEBI)

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • EC number
  • Short names
    DXP reductoisomerase
  • Alternative names
    • 1-deoxyxylulose-5-phosphate reductoisomerase
    • 2-C-methyl-D-erythritol 4-phosphate synthase

Gene names

    • Name
      ispC
    • Synonyms
      dxr
    • ORF names
      KPN_00186

Organism names

Accessions

  • Primary accession
    A6T4X5

Proteomes

PTM/Processing

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-1321-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Domain146-2391-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
Domain271-387DXP reductoisomerase C-terminal

Sequence similarities

Belongs to the DXR family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    400
  • Mass (Da)
    43,235
  • Last updated
    2007-08-21 v1
  • Checksum
    C51D7BFD0DB11983
MKQLTVLGSTGSIGCSTLDVVRHNPGRFSVAALVAGKNVDRMVEQCLEFTPRYAVMDDAQSAERLRTRLHEHGSRTEVLSGQQAAAEVAALDEVDQVMAAIVGAAGLVPTLAAIRAGKTVLLANKESLVTCGRLFMEAVQQSGARLLPVDSEHNAIFQSMPETIQQHLGYADLAQNGVSSILLTGSGGPFRETAVAELAAMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASAQQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMGWPQRLNSGVKPLDFCQLSNLSFSAPDYTRYPCLKLAMDAFDVGQAATTTLNAANEESVAAFLHGDIRFTDIAAVNLAVLDKMDLQEPQSIDDVLVIDAEARAIAHQQLQRLVAQA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000647
EMBL· GenBank· DDBJ
ABR75646.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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