A6QS12 · PFF1_AJECN
- ProteinVacuolar membrane protease
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids850 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
May be involved in vacuolar sorting and osmoregulation.
Cofactor
Note: Binds 2 Zn2+ ions per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 175 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 187 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 187 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | |||
Active site | 221 | Proton acceptor | |||
Binding site | 222 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | vacuolar membrane | |
Molecular Function | metal ion binding | |
Molecular Function | metalloexopeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVacuolar membrane protease
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Ajellomycetaceae > Histoplasma
Accessions
- Primary accessionA6QS12
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Vacuole membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-20 | Cytoplasmic | |||
Transmembrane | 21-41 | Helical; Name=1 | |||
Topological domain | 42-282 | Vacuolar | |||
Transmembrane | 283-303 | Helical; Name=2 | |||
Topological domain | 304-308 | Cytoplasmic | |||
Transmembrane | 309-329 | Helical; Name=3 | |||
Topological domain | 330-363 | Vacuolar | |||
Transmembrane | 364-384 | Helical; Name=4 | |||
Topological domain | 385-393 | Cytoplasmic | |||
Transmembrane | 394-414 | Helical; Name=5 | |||
Topological domain | 415-425 | Vacuolar | |||
Transmembrane | 426-446 | Helical; Name=6 | |||
Topological domain | 447-529 | Cytoplasmic | |||
Transmembrane | 530-550 | Helical; Name=7 | |||
Topological domain | 551-563 | Vacuolar | |||
Transmembrane | 564-584 | Helical; Name=8 | |||
Topological domain | 585-590 | Cytoplasmic | |||
Transmembrane | 591-611 | Helical; Name=9 | |||
Topological domain | 612-850 | Vacuolar | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000411691 | 1-850 | Vacuolar membrane protease | ||
Glycosylation | 53 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 116 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 119 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 630 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 658 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 702 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length850
- Mass (Da)94,074
- Last updated2007-08-21 v1
- MD5 Checksum8DC8CEFA0414AF9B53952B529DF3F6C3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH476655 EMBL· GenBank· DDBJ | EDN02304.1 EMBL· GenBank· DDBJ | Genomic DNA |