A6QLR9 · A6QLR9_BOVIN

  • Protein
    Mitogen-activated protein kinase 14
  • Gene
    MAPK14
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

136050100150200250300350
TypeIDPosition(s)Description
Binding site54ATP (UniProtKB | ChEBI)
Active site168Proton acceptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentglutamatergic synapse
Cellular Componentmitochondrion
Cellular Componentnuclear speck
Cellular Componentspindle pole
Molecular FunctionATP binding
Molecular FunctionMAP kinase activity
Molecular Functionmitogen-activated protein kinase p38 binding
Molecular FunctionNFAT protein binding
Molecular Functionprotein phosphatase binding
Biological Processangiogenesis
Biological Processbone development
Biological Processcartilage condensation
Biological Processcell morphogenesis
Biological Processcell surface receptor protein serine/threonine kinase signaling pathway
Biological Processcellular response to ionizing radiation
Biological Processcellular response to lipoteichoic acid
Biological Processcellular response to tumor necrosis factor
Biological Processcellular response to UV-B
Biological Processcellular response to vascular endothelial growth factor stimulus
Biological Processcellular response to virus
Biological Processchondrocyte differentiation
Biological ProcessDNA damage checkpoint signaling
Biological Processfatty acid oxidation
Biological Processglucose import
Biological Processglucose metabolic process
Biological Processlipopolysaccharide-mediated signaling pathway
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of hippo signaling
Biological Processosteoblast differentiation
Biological Processosteoclast differentiation
Biological Processp38MAPK cascade
Biological Processplacenta development
Biological Processpositive regulation of brown fat cell differentiation
Biological Processpositive regulation of cardiac muscle cell proliferation
Biological Processpositive regulation of erythrocyte differentiation
Biological Processpositive regulation of glucose import
Biological Processpositive regulation of interleukin-12 production
Biological Processpositive regulation of myoblast differentiation
Biological Processpositive regulation of myoblast fusion
Biological Processpositive regulation of myotube differentiation
Biological Processpositive regulation of protein import into nucleus
Biological Processpositive regulation of reactive oxygen species metabolic process
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of cytokine production involved in inflammatory response
Biological Processregulation of ossification
Biological Processregulation of synaptic membrane adhesion
Biological Processresponse to dietary excess
Biological Processresponse to insulin
Biological Processresponse to muramyl dipeptide
Biological Processresponse to muscle stretch
Biological Processskeletal muscle tissue development
Biological Processstem cell differentiation
Biological Processstress-activated MAPK cascade
Biological Processstress-induced premature senescence
Biological Processstriated muscle cell differentiation
Biological Processtranscription by RNA polymerase II
Biological Processvascular endothelial growth factor receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitogen-activated protein kinase 14
  • EC number
  • Alternative names
    • Mitogen-activated protein kinase p38 alpha

Gene names

    • Name
      MAPK14

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • L1 Hereford
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A6QLR9
  • Secondary accessions
    • F6PU21

Proteomes

Organism-specific databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-308Protein kinase

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    360
  • Mass (Da)
    41,493
  • Last updated
    2007-08-21 v1
  • Checksum
    062EBC3E56683D14
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1LTT9A0A3Q1LTT9_BOVINMAPK14360
A0AAA9T8X7A0AAA9T8X7_BOVINMAPK14307
A0A3Q1M517A0A3Q1M517_BOVINMAPK14345
A0A3Q1M8H8A0A3Q1M8H8_BOVINMAPK14350

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC148063
EMBL· GenBank· DDBJ
AAI48064.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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