A6QG30 · ISDB_STAAE
- ProteinIron-regulated surface determinant protein B
- GeneisdB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids645 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Cell wall-anchored surface receptor that extracts heme from oxidized metHb to enable growth on hemoglobin as a sole iron source (PubMed:17041042).
Rapidly extracts heme from hemoglobin and transfers it to IsdA or IsdC, which then relays it to the membrane transporter/IsdEF for internalization (PubMed:17041042, PubMed:19398548).
Promotes also resistance to hydrogen peroxide and killing by neutrophils (PubMed:18097052).
Rapidly extracts heme from hemoglobin and transfers it to IsdA or IsdC, which then relays it to the membrane transporter/IsdEF for internalization (PubMed:17041042, PubMed:19398548).
Promotes also resistance to hydrogen peroxide and killing by neutrophils (PubMed:18097052).
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | heme transmembrane transporter activity | |
Molecular Function | metal ion binding |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameIron-regulated surface determinant protein B
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionA6QG30
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Secreted, cell wall ; Peptidoglycan-anchor
Note: Anchored to the cell wall by sortase A.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, modified residue, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-40 | |||||
Sequence: MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQA | ||||||
Chain | PRO_0000317041 | 41-613 | Iron-regulated surface determinant protein B | |||
Sequence: AAEETGGTNTEAQPKTEAVASPTTTSEKAPETKPVANAVSVSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNNTYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKKDGTQQFYHYASSVKPARVIFTDSKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSSTHFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEDTKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPYVEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPATPSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKPTKGEVESSSTTPTKVVSTTQNVAKPTTASSKTTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNKNTQENKAKSLPQT | ||||||
Modified residue | 613 | Pentaglycyl murein peptidoglycan amidated threonine | ||||
Sequence: T | ||||||
Propeptide | PRO_0000317042 | 614-645 | Removed by sortase | |||
Sequence: GEESNKDMTLPLMALLALSSIVAFVLPRKRKN |
Keywords
- PTM
Expression
Induction
Repressed by fur in the presence of iron.
Structure
Family & Domains
Features
Showing features for motif, region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 12-23 | YSIRK-G/S signaling motif | ||||
Sequence: YSIRKSSLGVAS | ||||||
Region | 38-113 | Disordered | ||||
Sequence: AQAAAEETGGTNTEAQPKTEAVASPTTTSEKAPETKPVANAVSVSNKEVEAPTSETKEAKEVKEVKAPKETKEVKP | ||||||
Compositional bias | 41-87 | Polar residues | ||||
Sequence: AAEETGGTNTEAQPKTEAVASPTTTSEKAPETKPVANAVSVSNKEVE | ||||||
Compositional bias | 88-113 | Basic and acidic residues | ||||
Sequence: APTSETKEAKEVKEVKAPKETKEVKP | ||||||
Domain | 144-269 | NEAT 1 | ||||
Sequence: SAPNSRPIDFEMKKKDGTQQFYHYASSVKPARVIFTDSKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSSTHFNNKEEKYDYTLMEFAQPIYNSADKFKT | ||||||
Domain | 341-458 | NEAT 2 | ||||
Sequence: KMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPYVEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKAN | ||||||
Compositional bias | 458-472 | Basic and acidic residues | ||||
Sequence: NTDKSNKKEQQDNSA | ||||||
Region | 458-619 | Disordered | ||||
Sequence: NTDKSNKKEQQDNSAKKEATPATPSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKPTKGEVESSSTTPTKVVSTTQNVAKPTTASSKTTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNKNTQENKAKSLPQTGEESNK | ||||||
Compositional bias | 473-492 | Polar residues | ||||
Sequence: KKEATPATPSKPTPSPVEKE | ||||||
Compositional bias | 493-529 | Basic and acidic residues | ||||
Sequence: SQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKP | ||||||
Compositional bias | 530-619 | Polar residues | ||||
Sequence: TKGEVESSSTTPTKVVSTTQNVAKPTTASSKTTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNKNTQENKAKSLPQTGEESNK | ||||||
Motif | 610-614 | LPXTG sorting signal | ||||
Sequence: LPQTG |
Sequence similarities
Belongs to the IsdB family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length645
- Mass (Da)72,192
- Last updated2007-08-21 v1
- ChecksumC248D6CF84700B55
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 41-87 | Polar residues | ||||
Sequence: AAEETGGTNTEAQPKTEAVASPTTTSEKAPETKPVANAVSVSNKEVE | ||||||
Compositional bias | 88-113 | Basic and acidic residues | ||||
Sequence: APTSETKEAKEVKEVKAPKETKEVKP | ||||||
Compositional bias | 458-472 | Basic and acidic residues | ||||
Sequence: NTDKSNKKEQQDNSA | ||||||
Compositional bias | 473-492 | Polar residues | ||||
Sequence: KKEATPATPSKPTPSPVEKE | ||||||
Compositional bias | 493-529 | Basic and acidic residues | ||||
Sequence: SQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKP | ||||||
Compositional bias | 530-619 | Polar residues | ||||
Sequence: TKGEVESSSTTPTKVVSTTQNVAKPTTASSKTTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNKNTQENKAKSLPQTGEESNK |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP009351 EMBL· GenBank· DDBJ | BAF67312.1 EMBL· GenBank· DDBJ | Genomic DNA |