A6QDU7 · NANA_STAAE

Function

function

Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.

Catalytic activity

Pathway

Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 1/5.

Features

Showing features for binding site, active site.

129320406080100120140160180200220240260280
Type
IDPosition(s)Description
Binding site48aceneuramate (UniProtKB | ChEBI)
Binding site49aceneuramate (UniProtKB | ChEBI)
Active site137Proton donor
Active site165Schiff-base intermediate with substrate
Binding site167aceneuramate (UniProtKB | ChEBI)
Binding site189aceneuramate (UniProtKB | ChEBI)
Binding site191aceneuramate (UniProtKB | ChEBI)
Binding site192aceneuramate (UniProtKB | ChEBI)
Binding site208aceneuramate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionN-acetylneuraminate lyase activity
Biological Processcarbohydrate metabolic process
Biological ProcessN-acetylneuraminate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylneuraminate lyase
  • EC number
  • Short names
    NAL
    ; Neu5Ac lyase
  • Alternative names
    • N-acetylneuraminate pyruvate-lyase
    • N-acetylneuraminic acid aldolase
    • Sialate lyase
    • Sialic acid aldolase
    • Sialic acid lyase

Gene names

    • Name
      nanA
    • Ordered locus names
      NWMN_0257

Organism names

Accessions

  • Primary accession
    A6QDU7

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000731711-293N-acetylneuraminate lyase

Interaction

Subunit

Homotetramer.

Structure

Family & Domains

Sequence similarities

Belongs to the DapA family. NanA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    293
  • Mass (Da)
    33,043
  • Last updated
    2007-08-21 v1
  • Checksum
    62D7DEFFDC1AF431
MNKDLKGLYAALLVPFDENGQVNEQGLKQIAQNAIETEELDGLYVNGSSGENFLLNTEQKKQVFKVAKEAVGDKVKLIAQVGSLDLNEAIELGKYATELGYDALSAVTPFYYPFTFEEIRDYYFDIIEATQNNMIIYAIPDLTGVNISIEQFSELFNHEKIVGVKYTAPNFFLLERIRKAFPDKLILSGFDEMLVQATISGVDGAIGSTYNVNGRRARKIFDLARQGQIQEAYQLQHDSNDIIETVLSMGIYPTLKEILRHRGIDAGLPKRPFKPFNEAHRQTLDQLIAKYDL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP009351
EMBL· GenBank· DDBJ
BAF66529.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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