A6NH00 · OR2T8_HUMAN
- ProteinOlfactory receptor 2T8
- GeneOR2T8
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids312 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Odorant receptor.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | olfactory receptor activity | |
Biological Process | detection of chemical stimulus involved in sensory perception of smell |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOlfactory receptor 2T8
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA6NH00
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-26 | Extracellular | ||||
Sequence: MENGSYTSYFILLGLFNHTRAHQVLF | ||||||
Transmembrane | 27-47 | Helical; Name=1 | ||||
Sequence: MMVLSIVLTSLFGNSLMILLI | ||||||
Topological domain | 48-55 | Cytoplasmic | ||||
Sequence: HWDHRLHT | ||||||
Transmembrane | 56-76 | Helical; Name=2 | ||||
Sequence: PMYFLLSQLSLMDVMLVSTTV | ||||||
Topological domain | 77-96 | Extracellular | ||||
Sequence: PKMAADYLTGSKAISRAGCG | ||||||
Transmembrane | 97-117 | Helical; Name=3 | ||||
Sequence: AQIFFLPTLGGGECFLLAAMA | ||||||
Topological domain | 118-143 | Cytoplasmic | ||||
Sequence: YDRYAAVCHPLRYPTLMSWQLCLRMN | ||||||
Transmembrane | 144-164 | Helical; Name=4 | ||||
Sequence: LSCWLLGAADGLLQAVATLSF | ||||||
Topological domain | 165-201 | Extracellular | ||||
Sequence: PYCGAHEIDHFFCETPVLVRLACADTSVFENAMYICC | ||||||
Transmembrane | 202-222 | Helical; Name=5 | ||||
Sequence: VLMLLVPFSLILSSYGLILAA | ||||||
Topological domain | 223-234 | Cytoplasmic | ||||
Sequence: VLHMRSTEARKK | ||||||
Transmembrane | 235-255 | Helical; Name=6 | ||||
Sequence: AFATCSSHVAVVGLFYGAAIF | ||||||
Topological domain | 256-269 | Extracellular | ||||
Sequence: TYMRPKSHRSTNHD | ||||||
Transmembrane | 270-290 | Helical; Name=7 | ||||
Sequence: KVVSAFYTMFTPLLNPLIYSV | ||||||
Topological domain | 291-312 | Cytoplasmic | ||||
Sequence: KNSEVKGALTRCMGRCVALSRE |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_037342 | 39 | in dbSNP:rs11204563 | |||
Sequence: G → S | ||||||
Natural variant | VAR_037343 | 49 | in dbSNP:rs11204564 | |||
Sequence: W → R | ||||||
Natural variant | VAR_062028 | 69 | in dbSNP:rs28575687 | |||
Sequence: V → M | ||||||
Natural variant | VAR_037344 | 179 | in dbSNP:rs4584426 | |||
Sequence: T → A | ||||||
Natural variant | VAR_037345 | 197 | in dbSNP:rs4474294 | |||
Sequence: M → R | ||||||
Natural variant | VAR_037346 | 221 | in dbSNP:rs4362017 | |||
Sequence: A → S | ||||||
Natural variant | VAR_037347 | 305 | in dbSNP:rs6695357 | |||
Sequence: R → W | ||||||
Natural variant | VAR_062029 | 311 | in dbSNP:rs58882030 | |||
Sequence: R → H |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 429 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000311914 | 1-312 | Olfactory receptor 2T8 | |||
Sequence: MENGSYTSYFILLGLFNHTRAHQVLFMMVLSIVLTSLFGNSLMILLIHWDHRLHTPMYFLLSQLSLMDVMLVSTTVPKMAADYLTGSKAISRAGCGAQIFFLPTLGGGECFLLAAMAYDRYAAVCHPLRYPTLMSWQLCLRMNLSCWLLGAADGLLQAVATLSFPYCGAHEIDHFFCETPVLVRLACADTSVFENAMYICCVLMLLVPFSLILSSYGLILAAVLHMRSTEARKKAFATCSSHVAVVGLFYGAAIFTYMRPKSHRSTNHDKVVSAFYTMFTPLLNPLIYSVKNSEVKGALTRCMGRCVALSRE | ||||||
Glycosylation | 3 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 17 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 95↔177 | |||||
Sequence: CGAQIFFLPTLGGGECFLLAAMAYDRYAAVCHPLRYPTLMSWQLCLRMNLSCWLLGAADGLLQAVATLSFPYCGAHEIDHFFC |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Sequence
- Sequence statusComplete
- Length312
- Mass (Da)34,659
- Last updated2007-07-24 v1
- Checksum9708C7ABB1216EFD
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC099571 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |