A6NDX5 · ZN840_HUMAN
- ProteinPutative zinc finger protein 840
- GeneZNF840P
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids716 (go to sequence)
- Protein existenceUncertain
- Annotation score3/5
Function
function
May be involved in transcriptional regulation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
The subsequence PNCLSSSMQLPHGGGRHQELVRFRDVAVVFSPEEWDHLTPEQRNLYKDVMLDNCKYLASLGNWTYKAHVMSSLKQGKEPW, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.
Names & Taxonomy
Protein names
- Recommended namePutative zinc finger protein 840
- Alternative names
Gene names
- Community suggested namesZNF840P
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA6NDX5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_048027 | 181 | in dbSNP:rs3752261 | |||
Sequence: Y → C |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000332148 | 1-716 | Putative zinc finger protein 840 | |||
Sequence: MSLMGHGKVEMLLYAVPLLKAPNCLSSSMQLPHGGGRHQELVRFRDVAVVFSPEEWDHLTPEQRNLYKDVMLDNCKYLASLGNWTYKAHVMSSLKQGKEPWMMEREVTGDPCPACQPALATFRALNESGNAFRQSFHHGEYRTHRTFVQHYECDDCGMAFGHVSQLTGHQKIHKVGETHEYGENTRGFRHRSSFTMLQRICTLYKHFECNQCGETFNRPSKVIQHQSMHSGLKPYKCDVCQKAFRFLSSLSIHQRFHVGNRVNLTRHQKTHTQRKPFSCNFCGKTFHRFSEKTQHLLIHTRKKYYTCNYCKKEFNPYSKFILHQRTHTGEKPHKCDVCEKSFKSISNLNKHQKTHTGEKPFSCNECKKTFAQRTDLARHQQIHTGKKSFICSSCKKTFVRLSDLTQHKGTHTGERPYQCTTCEKAFKYRSNFTKHQKTHSIGRPFACNECGKTYRLNWELNQHKKIHTGEKPYECGECGKRFNNNSNLNKHKKIHTGEKHFVCNQCGKAFSLNSKLSRHQRTHNKKENSSKSVSNLNKHQKTHAGEKPFPCNECKKAFAQRMDLARHQQIHTGRKPFICSSCKKTFVRLSDLTQHKGTHTGERPYQCTTCEKAFKYQSNFTKHQKTHSIGRPFTCNECGKTFRLNWKLNQHKKIHTGEKPYECGECGKCFNNNSNLSKHKKIHTGEKHFVCNQCGKAFSLNSKLSRHQITHNKKKP |
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for domain, zinc finger, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 42-113 | KRAB | ||||
Sequence: VRFRDVAVVFSPEEWDHLTPEQRNLYKDVMLDNCKYLASLGNWTYKAHVMSSLKQGKEPWMMEREVTGDPCP | ||||||
Zinc finger | 151-173 | C2H2-type 1 | ||||
Sequence: YECDDCGMAFGHVSQLTGHQKIH | ||||||
Zinc finger | 207-229 | C2H2-type 2 | ||||
Sequence: FECNQCGETFNRPSKVIQHQSMH | ||||||
Zinc finger | 235-257 | C2H2-type 3 | ||||
Sequence: YKCDVCQKAFRFLSSLSIHQRFH | ||||||
Zinc finger | 277-299 | C2H2-type 4 | ||||
Sequence: FSCNFCGKTFHRFSEKTQHLLIH | ||||||
Zinc finger | 305-327 | C2H2-type 5 | ||||
Sequence: YTCNYCKKEFNPYSKFILHQRTH | ||||||
Zinc finger | 333-355 | C2H2-type 6 | ||||
Sequence: HKCDVCEKSFKSISNLNKHQKTH | ||||||
Zinc finger | 361-383 | C2H2-type 7 | ||||
Sequence: FSCNECKKTFAQRTDLARHQQIH | ||||||
Zinc finger | 389-411 | C2H2-type 8 | ||||
Sequence: FICSSCKKTFVRLSDLTQHKGTH | ||||||
Zinc finger | 417-439 | C2H2-type 9 | ||||
Sequence: YQCTTCEKAFKYRSNFTKHQKTH | ||||||
Zinc finger | 445-467 | C2H2-type 10 | ||||
Sequence: FACNECGKTYRLNWELNQHKKIH | ||||||
Zinc finger | 473-495 | C2H2-type 11 | ||||
Sequence: YECGECGKRFNNNSNLNKHKKIH | ||||||
Zinc finger | 501-523 | C2H2-type 12 | ||||
Sequence: FVCNQCGKAFSLNSKLSRHQRTH | ||||||
Region | 515-548 | Disordered | ||||
Sequence: KLSRHQRTHNKKENSSKSVSNLNKHQKTHAGEKP | ||||||
Zinc finger | 549-571 | C2H2-type 13 | ||||
Sequence: FPCNECKKAFAQRMDLARHQQIH | ||||||
Zinc finger | 577-599 | C2H2-type 14 | ||||
Sequence: FICSSCKKTFVRLSDLTQHKGTH | ||||||
Zinc finger | 605-627 | C2H2-type 15 | ||||
Sequence: YQCTTCEKAFKYQSNFTKHQKTH | ||||||
Zinc finger | 633-655 | C2H2-type 16 | ||||
Sequence: FTCNECGKTFRLNWKLNQHKKIH | ||||||
Zinc finger | 661-683 | C2H2-type 17 | ||||
Sequence: YECGECGKCFNNNSNLSKHKKIH | ||||||
Zinc finger | 689-711 | C2H2-type 18 | ||||
Sequence: FVCNQCGKAFSLNSKLSRHQITH |
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length716
- Mass (Da)83,235
- Last updated2008-12-16 v5
- Checksum32A5D13B52610D4B
Keywords
- Technical term