study provides novel evidence that MURC regulates SOCE by interacting with STIM1 in cardiomyocytes. In addition we identified a first potential mechanism by which the R140W mutation of MURC may contribute to calcium mishandling and the development of cardiomyopathies.
MURC modulates RhoA signaling and MURC plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias.
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